Published in Proc Natl Acad Sci U S A on April 03, 2007
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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res (2010) 1.17
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Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
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Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice. Oncotarget (2016) 0.90
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours. Br J Cancer (2011) 0.87
Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development. Mol Cell Biol (2010) 0.85
Disturbed B and T cell homeostasis and neogenesis in patients with ataxia telangiectasia. J Clin Immunol (2014) 0.83
ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire. PLoS One (2013) 0.81
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes. Nucleic Acids Res (2013) 0.81
Kruppel-associated box (KRAB) proteins in the adaptive immune system. Nucleus (2014) 0.80
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Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease. Immunology (2015) 0.76
The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. J Immunol (2016) 0.75
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Identification of V(D)J recombination coding end intermediates in normal thymocytes. J Mol Biol (1997) 1.15
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev (2006) 1.15
ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes. Blood (2006) 1.13
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04
Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene. J Immunol (2000) 1.03
CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells. J Exp Med (2003) 1.01
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Mol Cell Biol (2002) 1.00
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J Immunol (2005) 0.98
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection. Eur J Immunol (2005) 0.93
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med (2000) 0.90
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J Immunol (2005) 4.10
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J Immunol (2005) 2.01
Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med (2004) 1.87
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One (2008) 1.86
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
Haploinsufficiency of mTR results in defects in telomere elongation. Proc Natl Acad Sci U S A (2002) 1.56
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length. J Immunother (2007) 1.46
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol (2004) 1.46
Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation. Inflamm Bowel Dis (2011) 1.33
In vivo regulation of telomerase activity and telomere length. Immunol Rev (2005) 1.27
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. Proc Natl Acad Sci U S A (2005) 1.21
Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation. J Immunol (2004) 1.19
Critical role of IRF-5 in regulation of B-cell differentiation. Proc Natl Acad Sci U S A (2010) 1.19
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem (2010) 1.17
Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A (2010) 1.15
Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer. Clin Cancer Res (2007) 1.13
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol (2006) 1.13
The future of aging therapies. Cell (2005) 1.13
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features. PLoS One (2008) 1.12
Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression. Cancer Epidemiol Biomarkers Prev (2008) 1.10
Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis. Cancer (2008) 1.10
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl. Proc Natl Acad Sci U S A (2010) 1.09
Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway. J Immunol (2008) 1.09
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol (2004) 1.08
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J (2010) 1.08
Abnormal differentiation of memory T cells in systemic lupus erythematosus. Arthritis Rheum (2006) 1.06
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo. J Immunol (2003) 1.02
CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells. J Exp Med (2003) 1.01
Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int J Cancer (2008) 1.01
Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene. Mol Immunol (2005) 1.01
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Mol Cell Biol (2002) 1.00
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J Immunol (2005) 0.98
Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. Cancer Res (2008) 0.98
Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. J Immunol (2003) 0.98
Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy. J Immunol (2005) 0.96
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor. J Immunol (2004) 0.96
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. Int J Cancer (2009) 0.94
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection. Eur J Immunol (2005) 0.93
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J Exp Med (2004) 0.90
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes. J Immunol (2002) 0.87
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol (2013) 0.86
Telomere and microtubule targeting in treatment-sensitive and treatment-resistant human prostate cancer cells. Mol Pharmacol (2012) 0.85
Analysis of telomere length and telomerase activity. Curr Protoc Immunol (2004) 0.84
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. J Biol Chem (2008) 0.84
Cbl enforces Vav1 dependence and a restricted pathway of T cell development. PLoS One (2011) 0.84
Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. J Immunol (2010) 0.82
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A (2013) 0.82
Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. PLoS One (2007) 0.81
ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire. PLoS One (2013) 0.81
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes. Nucleic Acids Res (2013) 0.81
Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway. J Immunol (2007) 0.80
A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restriction. J Immunol (2013) 0.78
Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. J Immunol (2012) 0.78
Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One (2012) 0.78
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement. PLoS One (2011) 0.76
National Institute on Aging at middle age--its past, present, and future. J Am Geriatr Soc (2012) 0.75
Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy. PLoS One (2008) 0.75
Don't forget to prescribe exercise for your older patients. Arch Intern Med (2004) 0.75
Response to: "Rescuing the NIH before it is too late". J Clin Invest (2006) 0.75
Editorial overview. Curr Opin Immunol (2012) 0.75
Telomere biology and immune system. Discov Med (2005) 0.75
National Institute on Aging. Interview by Vicki Glaser. Rejuvenation Res (2006) 0.75