Published in Cell Cycle on June 15, 2011
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell (2016) 1.88
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
Chromatin modifications and the DNA damage response to ionizing radiation. Front Oncol (2013) 0.95
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med (2011) 0.91
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. EMBO J (2016) 0.83
Structural studies of DNA end detection and resection in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.78
TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair (Amst) (2015) 0.77
Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle (2012) 0.77
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination. Int J Biol Sci (2014) 0.75
XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma. Int J Genomics (2013) 0.75
DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes. J Immunol (2012) 0.75
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Somatic generation of antibody diversity. Nature (1983) 28.06
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol (2000) 13.46
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem (2001) 8.78
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
H2AX: the histone guardian of the genome. DNA Repair (Amst) (2004) 6.65
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol (2002) 6.44
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
The DNA-dependent protein kinase. Genes Dev (1999) 5.80
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55
V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem (2001) 5.44
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell (1987) 4.70
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (2004) 4.58
In situ visualization of DNA double-strand break repair in human fibroblasts. Science (1998) 4.53
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell (1988) 4.34
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science (2006) 4.23
The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol (2000) 4.17
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science (2000) 3.95
The scid mutation in mice causes a general defect in DNA repair. Nature (1990) 3.85
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A (1991) 3.69
The genetic defect in ataxia-telangiectasia. Annu Rev Immunol (1997) 3.69
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc Natl Acad Sci U S A (1992) 3.58
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity (1998) 3.58
ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
DNA end-joining catalyzed by human cell-free extracts. Proc Natl Acad Sci U S A (1998) 3.11
Evidence of functional lymphocytes in some (leaky) scid mice. J Exp Med (1988) 3.09
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci U S A (1995) 2.99
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93
Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol Cell (1998) 2.86
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell (1988) 2.71
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst) (2004) 2.68
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell (1997) 2.58
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity (1998) 2.43
Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res (1993) 2.39
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
The p53 response to DNA damage. DNA Repair (Amst) (2004) 2.14
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol (2002) 2.07
Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol (1996) 2.02
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) (2004) 1.93
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A (2001) 1.91
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev (1994) 1.85
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature (2006) 1.82
DNA damage and the DNA-activated protein kinase. Trends Biochem Sci (1993) 1.79
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A (2007) 1.69
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature (2010) 1.64
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst) (2003) 1.55
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep (2009) 1.46
Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends. Proc Natl Acad Sci U S A (2001) 1.42
A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol (1997) 1.41
Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol (2001) 1.38
Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia. Hum Mutat (1997) 1.37
ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks. Proc Natl Acad Sci U S A (2007) 1.31
End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair (Amst) (2004) 1.29
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) (2008) 1.29
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem (1993) 1.29
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc Natl Acad Sci U S A (1995) 1.27
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc Natl Acad Sci U S A (1998) 1.26
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair (Amst) (2005) 1.24
Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products. Mol Cell Biol (1997) 1.18
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U S A (2011) 1.17
Phosphorylation of Artemis following irradiation-induced DNA damage. Eur J Immunol (2004) 1.16
AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell (2010) 1.16
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev (2006) 1.15
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med (2003) 1.55
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A (2009) 1.50
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol (2008) 1.48
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
Allelic exclusion at the TCRbeta locus. Curr Opin Immunol (2002) 1.30
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med (2006) 1.17
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol (2006) 1.16
Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly. Eur J Immunol (2005) 1.11
Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol (2005) 1.06
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04
Collateral damage from antigen receptor gene diversification. Cell (2008) 1.03
MAPK p38 alpha is dispensable for lymphocyte development and proliferation. J Immunol (2005) 1.03
β-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A (2013) 1.03
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A (2003) 0.99
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. J Immunol (2008) 0.94
The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med (2013) 0.93
Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med (2011) 0.91
T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction. Eur J Immunol (2003) 0.89
Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction. Immunol Rev (2004) 0.89
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med (2002) 0.88
Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors. J Immunol (2003) 0.88
Developmental stage-specific regulation of TCR-alpha-chain gene assembly by intrinsic features of the TEA promoter. J Immunol (2007) 0.87
Lymphocyte development: integration of DNA damage response signaling. Adv Immunol (2012) 0.87
Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development. J Immunol (2002) 0.87
The B12/23 restriction is critically dependent on recombination signal nonamer and spacer sequences. J Immunol (2003) 0.83
Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. J Immunol (2011) 0.82
Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol (2002) 0.81
Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus. Mol Immunol (2008) 0.81
Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc Natl Acad Sci U S A (2013) 0.81
Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination. J Exp Med (2002) 0.81
Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes. J Immunol (2012) 0.80
Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment. Int Immunol (2005) 0.80
Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J Immunol (2013) 0.80
The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination. Mol Cell Biol (2013) 0.78
Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle (2012) 0.77
DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs. BMC Genomics (2013) 0.77
Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo. PLoS One (2011) 0.77
SWI-SNF: promoter of accessibility. Nat Immunol (2007) 0.75
ATM deficiency: revealing the pathways to cancer. Cell Cycle (2014) 0.75