Published in Nat Protoc on January 01, 2007
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A (2008) 4.89
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc (2009) 3.65
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell (2013) 3.02
Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A (2013) 2.96
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat Med (2014) 2.39
Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol (2008) 2.36
Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat Med (2015) 2.27
Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells. Nat Protoc (2012) 2.12
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
Mitochondrial structure and function are disrupted by standard isolation methods. PLoS One (2011) 1.74
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem (2010) 1.71
Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Proc Natl Acad Sci U S A (2013) 1.69
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med (2016) 1.55
Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc (2012) 1.54
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res (2012) 1.53
Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Exp Neurol (2013) 1.52
Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Cell Metab (2016) 1.48
ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Mol Cell (2015) 1.46
Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.46
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem (2011) 1.46
High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. Endocrinology (2013) 1.46
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab (2015) 1.43
Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy. J Clin Invest (2011) 1.43
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. J Clin Invest (2011) 1.42
NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep (2016) 1.40
BH3 profiling in whole cells by fluorimeter or FACS. Methods (2013) 1.40
The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature (2017) 1.39
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep (2012) 1.35
Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A (2012) 1.33
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radic Biol Med (2010) 1.33
Methods for assessing mitochondrial function in diabetes. Diabetes (2013) 1.31
Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics (2011) 1.28
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27
Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy. Exp Neurol (2011) 1.24
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism. J Cell Biol (2012) 1.23
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes (2013) 1.22
Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease. J Biol Chem (2010) 1.20
Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin. Cell Death Differ (2010) 1.19
Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes (2010) 1.18
Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol (2011) 1.18
PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun (2012) 1.18
Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport. J Cell Biol (2013) 1.18
Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes (2010) 1.17
Top down proteomics of human membrane proteins from enriched mitochondrial fractions. Anal Chem (2013) 1.15
Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc (2014) 1.15
Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO Rep (2010) 1.15
Mitochondria: isolation, structure and function. J Physiol (2011) 1.14
Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. J Cell Biol (2014) 1.09
Conjugated linoleic acid is a preferential substrate for fatty acid nitration. J Biol Chem (2012) 1.09
Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease. Proc Natl Acad Sci U S A (2013) 1.06
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab (2015) 1.05
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep (2015) 1.05
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta (2011) 1.05
A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun (2015) 1.04
LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem (2011) 1.03
Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol (2011) 1.03
Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol (2016) 1.03
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J Cell Biol (2016) 1.01
Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients (2013) 1.01
Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.01
Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads. PLoS One (2013) 1.01
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Br J Anaesth (2013) 1.00
Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. Biochem Pharmacol (2011) 1.00
Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep (2013) 1.00
Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A (2016) 1.00
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina. J Biol Chem (2013) 1.00
Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin. J Cell Biol (2009) 0.99
Characterization of distinct single-channel properties of Ca²⁺ inward currents in mitochondria. Pflugers Arch (2013) 0.99
Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2009) 0.99
Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J (2010) 0.99
Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med (2012) 0.99
Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models. Cell Metab (2015) 0.98
Glutaredoxin 2 prevents H(2)O(2)-induced cell apoptosis by protecting complex I activity in the mitochondria. Biochim Biophys Acta (2010) 0.97
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem (2012) 0.97
Modeling kinetics of subcellular disposition of chemicals. Chem Rev (2009) 0.96
A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. Cell Rep (2013) 0.96
Insulator-based dielectrophoresis of mitochondria. Biomicrofluidics (2014) 0.96
Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci U S A (2014) 0.96
Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity. Hum Mol Genet (2010) 0.96
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. J Biol Chem (2013) 0.95
Cholesterol effects on BAX pore activation. J Mol Biol (2008) 0.95
Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice. PLoS One (2009) 0.95
Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells. Free Radic Biol Med (2011) 0.95
The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. J Biol Chem (2009) 0.95
Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux. J Immunol (2014) 0.94
Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization. Anal Biochem (2011) 0.94
Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit. Biochem J (2015) 0.94
Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice. PLoS One (2012) 0.94
Mitochondrial Toxicity of Cadmium Telluride Quantum Dot Nanoparticles in Mammalian Hepatocytes. Toxicol Sci (2015) 0.94
Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol (2013) 0.93
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis. Cell Death Differ (2009) 0.93
Protein carbonylation and adipocyte mitochondrial function. J Biol Chem (2012) 0.93
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A (2004) 5.34
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell (2013) 3.02
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J (2010) 2.74
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. J Exp Med (2006) 2.10
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell (2002) 2.09
The relationship between mitochondrial shape and function and the cytoskeleton. Biochim Biophys Acta (2006) 2.02
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J (2010) 2.01
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med (2010) 1.72
LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability. Hum Mol Genet (2007) 1.64
The changing shape of mitochondrial apoptosis. Trends Endocrinol Metab (2009) 1.62
Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J (2006) 1.53
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta (2008) 1.44
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science (2013) 1.39
(De)constructing mitochondria: what for? Physiology (Bethesda) (2006) 1.37
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol (2003) 1.30
Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem (2004) 1.27
Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate. Circ Res (2010) 1.24
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function. Hum Mol Genet (2008) 1.20
Mitochondrial morphology in mitophagy and macroautophagy. Biochim Biophys Acta (2012) 1.20
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J (2013) 1.16
Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO Rep (2010) 1.15
Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras. Mitochondrion (2009) 1.14
Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria. J Biol Chem (2011) 1.11
Shaping the role of mitochondria in the pathogenesis of Huntington's disease. EMBO J (2012) 1.11
Mitofusin 2: a mitochondria-shaping protein with signaling roles beyond fusion. Antioxid Redox Signal (2008) 1.07
Traveling Bax and forth from mitochondria to control apoptosis. Cell (2011) 1.04
Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Curr Biol (2012) 0.96
The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. Adv Exp Med Biol (2010) 0.95
Cell death induced by granzyme C. Blood (2002) 0.93
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One (2013) 0.93
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1. J Gen Physiol (2012) 0.92
Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration. Acta Neuropathol (2011) 0.91
KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. J Cell Sci (2009) 0.91
Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation. Hum Mol Genet (2012) 0.91
Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry. Neurobiol Dis (2013) 0.91
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc Natl Acad Sci U S A (2003) 0.90
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol (2014) 0.90
Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development. Diabetes (2013) 0.89
Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases. Int J Cell Biol (2012) 0.88
When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum. EMBO J (2009) 0.88
Reactive oxygen species are NOXious for neurons. Nat Neurosci (2009) 0.87
Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis. Cell Death Differ (2003) 0.86
Mitochondrial elongation during autophagy: a stereotypical response to survive in difficult times. Autophagy (2011) 0.86
Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors. J Biol Chem (2002) 0.86
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock. Biochim Biophys Acta (2012) 0.86
Measuring mitochondrial shape changes and their consequences on mitochondrial involvement during apoptosis. Methods Mol Biol (2007) 0.85
Apaf1 plays a pro-survival role by regulating centrosome morphology and function. J Cell Sci (2011) 0.85
Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy. Cell Cycle (2011) 0.84
D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries. Mol Cell Neurosci (2012) 0.83
Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology. Thromb Haemost (2014) 0.82
Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. J Invest Dermatol (2012) 0.80
Mitochondrial dynamics and physiology. Biochim Biophys Acta (2012) 0.80
O ROM(e)O1, ROM(e)O1, wherefore art thou ROM(e)O1? Sci Signal (2014) 0.79
Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling. Chem Biol (2011) 0.78
A BID on mitochondria with MTCH2. Cell Res (2010) 0.77
Understanding allergy and cancer risk: what are the barriers? Nat Rev Cancer (2015) 0.77
Tonight, the same old, deadly programme: BH3-only proteins, mitochondria and yeast. EMBO J (2011) 0.77
Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease. EMBO J (2012) 0.75
In epilepsy, BAD is not really bad. Neuron (2012) 0.75
Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. J Biol Chem (2016) 0.75
Phagocytosis: coupling of mitochondrial uncoupling and engulfment. Curr Biol (2011) 0.75
Seminars in Cell & Developmental Biology. Editorial. Semin Cell Dev Biol (2010) 0.75
Stanley J. Korsmeyer (1950-2005). J Bioenerg Biomembr (2005) 0.75