Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock.

Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhage*. Crit Care Med (2012) 1.51

Fluid resuscitation: past, present, and the future. Shock (2010) 1.44

Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Mol Med (2012) 1.09

Resuscitation with fresh whole blood ameliorates the inflammatory response after hemorrhagic shock. J Trauma (2010) 0.98

Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock (2012) 0.98

Pulmonary contusion primes systemic innate immunity responses. J Trauma (2009) 0.93

Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Biochim Biophys Acta (2011) 0.91

Hypertonic saline resuscitation reduces apoptosis of intestinal mucosa in a rat model of hemorrhagic shock. J Zhejiang Univ Sci B (2008) 0.88

Immune depression in musculoskeletal trauma. Inflamm Res (2010) 0.87

Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury. Mol Med (2010) 0.87

Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem (2012) 0.86

ROC trials update on prehospital hypertonic saline resuscitation in the aftermath of the US-Canadian trials. Clinics (Sao Paulo) (2013) 0.85

Blast injury research models. Philos Trans R Soc Lond B Biol Sci (2011) 0.85

Peripheral osmotic stimulation inhibits the brain's innate immune response to microdialysis of acidic perfusion fluid adjacent to supraoptic nucleus. Am J Physiol Regul Integr Comp Physiol (2009) 0.82

Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress. Crit Care (2008) 0.81

Research studies that have influenced practice of neuroanesthesiology in recent years: A literature review. Indian J Anaesth (2013) 0.81

7.5% saline and 7.5% saline/6% dextran for hypovolemic shock. J Trauma (2011) 0.81

Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury. Shock (2013) 0.80

Advances in resuscitation strategies. Int J Surg (2010) 0.79

Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients. J Res Med Sci (2014) 0.78

Is the sympathetic system involved in shock-induced gut and lung injury? J Trauma Acute Care Surg (2012) 0.78

Effect of Hypotensive Resuscitation with a Novel Combination of Fluids in a Rabbit Model of Uncontrolled Hemorrhagic Shock. PLoS One (2013) 0.77

Hypertonic Saline Dextran Ameliorates Organ Damage in Beagle Hemorrhagic Shock. PLoS One (2015) 0.76

A quantitative study of lung dysfunction following haemorrhagic shock in rats. Int J Exp Pathol (2009) 0.76

Risk factors for trauma-induced coagulopathy- and transfusion-associated multiple organ failure in severely injured trauma patients. Front Med (Lausanne) (2015) 0.75

Optimal Fluid Therapy for Traumatic Hemorrhagic Shock. Crit Care Clin (2017) 0.75

Infarct volume after hyperacute infusion of hypertonic saline in a rat model of acute embolic stroke. Neurocrit Care (2013) 0.75

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med (1995) 10.29

Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA (2004) 3.54

Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis. Blood (1996) 1.87

Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. Ann Surg (1991) 1.75

Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader. Methods Enzymol (1986) 1.67

Alteration of monocyte function following major injury. Arch Surg (1988) 1.64

The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: a randomized, controlled, double-blinded trial. Ann Surg (2006) 1.56

Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. J Immunol (1998) 1.36

Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest (1998) 1.31

Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock (1998) 1.31

Definition of human blood monocytes. J Leukoc Biol (2000) 1.25

Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies. Surgery (1997) 1.24

Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock (1997) 1.24

A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients. Arch Surg (1993) 1.24

Individual patient cohort analysis of the efficacy of hypertonic saline/dextran in patients with traumatic brain injury and hypotension. J Trauma (1997) 1.20

Hypertonic inhibition of exocytosis in neutrophils: central role for osmotic actin skeleton remodeling. Am J Physiol Cell Physiol (2000) 1.18

7.5% sodium chloride/dextran for resuscitation of trauma patients undergoing helicopter transport. Arch Surg (1991) 1.16

A rapid densitometric microassay for nitroblue tetrazolium reduction and application of the microassay to macrophages. J Reticuloendothel Soc (1981) 1.14

A comparison of several hypertonic solutions for resuscitation of bled sheep. J Surg Res (1985) 1.09

CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand J Immunol (2002) 1.09

Hypertonic saline resuscitation reduces neutrophil margination by suppressing neutrophil L selectin expression. J Trauma (1998) 1.07

Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. J Immunol (2002) 1.07

Effect of dose of hypertonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock. Shock (2003) 1.06

Hypertonic immunomodulation is reversible and accompanied by changes in CD11b expression. J Surg Res (1999) 1.05

Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room. Surgery (1992) 1.04

Pathogenesis of multiple organ dysfunction syndrome--endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species. Surg Infect (Larchmt) (2000) 1.02

Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma. J Trauma (2003) 1.01

Hypertonicity prevents lipopolysaccharide-stimulated CD11b/CD18 expression in human neutrophils in vitro: role for p38 inhibition. J Trauma (1999) 0.99

Monocytes with altered phenotypes in posttrauma patients. Arch Pathol Lab Med (2003) 0.98

Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome. J Trauma (1990) 0.96

Immune effect of hypertonic saline: fact or fiction? Acta Anaesthesiol Scand (2004) 0.96

Use of a 7.5% NaCl/6% Dextran 70 solution in the resuscitation of injured patients in the emergency room. Prog Clin Biol Res (1989) 0.91

Effects of hypertonic saline on expression of human polymorphonuclear leukocyte adhesion molecules. J Leukoc Biol (2001) 0.91

Lower dose of hypertonic saline dextran reduces the risk of lethal rebleeding in uncontrolled hemorrhage. Shock (2002) 0.88

Release of proinflammatory cytokines by mitogen-stimulated peripheral blood mononuclear cells from critically ill multiple-trauma victims. Metabolism (1999) 0.87

Efficacy of hypertonic saline dextran (HSD) in patients with traumatic hypotension: meta-analysis of individual patient data. Acta Anaesthesiol Scand Suppl (1997) 0.85

The effects of repeated dosing with 7.5% sodium chloride/6% dextran following uncontrolled intra-abdominal hemorrhage. Shock (2002) 0.80

Superiority of hypertonic saline/dextran over hypertonic saline during the first 30 min of resuscitation following hemorrhagic hypotension in conscious swine. Resuscitation (1990) 0.78

Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74

A genomic storm in critically injured humans. J Exp Med (2011) 6.67

Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med (2013) 3.65

Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49

Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22

Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program. Ann Surg (2008) 2.82

Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP) in the trauma patient. J Trauma (2006) 2.57

Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma (2009) 2.49

Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg (2012) 2.32

High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25

Timing of intubation and ventilator-associated pneumonia following injury. Arch Surg (2010) 2.23

Active surveillance cultures of methicillin-resistant Staphylococcus aureus as a tool to predict methicillin-resistant S. aureus ventilator-associated pneumonia. Crit Care Med (2012) 2.17

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17

An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma (2008) 2.15

Acute care surgery: Eraritjaritjaka. J Am Coll Surg (2006) 2.12

Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med (2008) 2.10

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07

Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients. Arch Surg (2010) 2.03

Patterns of errors contributing to trauma mortality: lessons learned from 2,594 deaths. Ann Surg (2006) 2.02

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94

Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg (2002) 1.92

Development of trauma systems and effect on outcomes after injury. Lancet (2004) 1.82

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82

Variations in rates of tracheostomy in the critically ill trauma patient. Crit Care Med (2006) 1.79

Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation. J Trauma (2006) 1.78

The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma (2007) 1.76

Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient. J Trauma (2005) 1.73

Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg (2008) 1.71

Source control in the management of severe sepsis and septic shock: an evidence-based review. Crit Care Med (2004) 1.65

Early use of vasopressors after injury: caution before constriction. J Trauma (2008) 1.64

Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62

A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med (2014) 1.62

Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62

Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 1.60

An International Normalized Ratio-Based Definition of Acute Traumatic Coagulopathy Is Associated With Mortality, Venous Thromboembolism, and Multiple Organ Failure After Injury. Crit Care Med (2015) 1.56

Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patient. J Trauma (2006) 1.52

Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury. J Trauma (2009) 1.52

Male gender is associated with excessive IL-6 expression following severe injury. J Trauma (2008) 1.51

A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48

The impact of an intensivist-model ICU on trauma-related mortality. Ann Surg (2006) 1.46

Do trauma centers have the capacity to respond to disasters? J Trauma (2006) 1.46

Traumatic injury, early gene expression, and gram-negative bacteremia. Crit Care Med (2014) 1.45

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient. J Trauma (2007) 1.37

Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg (2013) 1.36

Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33

Inclusive trauma systems: do they improve triage or outcomes of the severely injured? J Trauma (2006) 1.33

Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. J Trauma (2009) 1.29

Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg (2010) 1.27

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients. J Trauma (2008) 1.21

Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient. J Trauma (2008) 1.20

Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect Immun (2002) 1.18

Haemorrhage control in severely injured patients. Lancet (2012) 1.17

Gossypiboma: tales of lost sponges and lessons learned. Arch Surg (2010) 1.16

Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure. Shock (2010) 1.16

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient. J Trauma (2008) 1.12

Temporal trends of postinjury multiple-organ failure: still resource intensive, morbid, and lethal. J Trauma Acute Care Surg (2014) 1.11

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study. PLoS Med (2011) 1.11

The risk for bloodstream infections is associated with increased parenteral caloric intake in patients receiving parenteral nutrition. Crit Care (2007) 1.10

Early hyperglycemia predicts multiple organ failure and mortality but not infection. J Trauma (2007) 1.09

NIH Roundtable on Emergency Trauma Research. Ann Emerg Med (2010) 1.09

Changes in massive transfusion over time: an early shift in the right direction? J Trauma Acute Care Surg (2012) 1.07

Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. J Immunol (2002) 1.07

The effect of interfacility transfer on outcome in an urban trauma system. J Trauma (2003) 1.07

Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Ann Surg (2009) 1.06

Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuries. J Trauma (2002) 1.04

The association between the transfusion of older blood and outcomes after trauma. Shock (2011) 1.04

Acute kidney injury is associated with early cytokine changes after trauma. J Trauma Acute Care Surg (2013) 1.02

Acid sphingomyelinase is required for lipid Raft TLR4 complex formation. Surg Infect (Larchmt) (2007) 1.01

Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14. J Leukoc Biol (2006) 1.00

Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way. J Trauma Acute Care Surg (2012) 1.00

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem (2008) 0.99

Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock (2012) 0.98

The role of repeat angiography in the management of pelvic fractures. J Trauma (2005) 0.98

Identification and interpretation of longitudinal gene expression changes in trauma. PLoS One (2010) 0.98