Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 17381401)

Published in Surg Infect (Larchmt) on February 01, 2007

Authors

Joseph Cuschieri1, Eileen Bulger, Jens Billgrin, Iris Garcia, Ronald V Maier

Author Affiliations

1: Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA. jcuschie@u.washington.edu

Articles citing this

The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68

Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol (2009) 1.87

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J (2008) 1.73

Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. Am J Pathol (2007) 1.67

Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling. J Immunol (2011) 1.66

Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling. Cell Mol Life Sci (2014) 1.18

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience (2010) 1.07

Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Mol Cell Proteomics (2008) 1.07

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab (2013) 0.97

Temporal aspects of the action of ASA404 (vadimezan; DMXAA). Expert Opin Investig Drugs (2010) 0.85

Acid sphingomyelinase in macrophage biology. Cell Mol Life Sci (2011) 0.84

Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression. J Biol Chem (2011) 0.81

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood (2014) 0.79

Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis. Mol Med (2016) 0.76

Articles by these authors

Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74

A genomic storm in critically injured humans. J Exp Med (2011) 6.67

Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49

Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22

Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP) in the trauma patient. J Trauma (2006) 2.57

Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma (2009) 2.49

Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg (2012) 2.32

Predictors of mortality and limb loss in necrotizing soft tissue infections. Arch Surg (2005) 2.27

High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25

Timing of intubation and ventilator-associated pneumonia following injury. Arch Surg (2010) 2.23

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17

An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma (2008) 2.15

Acute care surgery: Eraritjaritjaka. J Am Coll Surg (2006) 2.12

Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med (2008) 2.10

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07

Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients. Arch Surg (2010) 2.03

Patterns of errors contributing to trauma mortality: lessons learned from 2,594 deaths. Ann Surg (2006) 2.02

Safety and efficacy of video-assisted retroperitoneal debridement for infected pancreatic collections: a multicenter, prospective, single-arm phase 2 study. Arch Surg (2010) 1.99

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94

Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg (2002) 1.92

Influence of definition and location of hypotension on outcome following severe pediatric traumatic brain injury. Crit Care Med (2005) 1.83

Development of trauma systems and effect on outcomes after injury. Lancet (2004) 1.82

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82

Variations in rates of tracheostomy in the critically ill trauma patient. Crit Care Med (2006) 1.79

Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation. J Trauma (2006) 1.78

The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma (2007) 1.76

Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient. J Trauma (2005) 1.73

Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg (2008) 1.71

Source control in the management of severe sepsis and septic shock: an evidence-based review. Crit Care Med (2004) 1.65

Early use of vasopressors after injury: caution before constriction. J Trauma (2008) 1.64

Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care (2013) 1.62

Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62

A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med (2014) 1.62

Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62

Hypertonic resuscitation: design and implementation of a prehospital intervention trial. J Am Coll Surg (2007) 1.61

Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 1.60

An International Normalized Ratio-Based Definition of Acute Traumatic Coagulopathy Is Associated With Mortality, Venous Thromboembolism, and Multiple Organ Failure After Injury. Crit Care Med (2015) 1.56

Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patient. J Trauma (2006) 1.52

Male gender is associated with excessive IL-6 expression following severe injury. J Trauma (2008) 1.51

A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48

The impact of an intensivist-model ICU on trauma-related mortality. Ann Surg (2006) 1.46

Variation in the type, rate, and selection of patients for out-of-hospital airway procedures among injured children and adults. Acad Emerg Med (2009) 1.46

Do trauma centers have the capacity to respond to disasters? J Trauma (2006) 1.46

Traumatic injury, early gene expression, and gram-negative bacteremia. Crit Care Med (2014) 1.45

Variability in pediatric splenic injury care: results of a national survey of general surgeons. Arch Surg (2010) 1.45

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient. J Trauma (2007) 1.37

Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg (2013) 1.36

Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33

Inclusive trauma systems: do they improve triage or outcomes of the severely injured? J Trauma (2006) 1.33

Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. J Trauma (2009) 1.29

Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg (2010) 1.27

Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg (2007) 1.23

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients. J Trauma (2008) 1.21

Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient. J Trauma (2008) 1.20

Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect Immun (2002) 1.18

Haemorrhage control in severely injured patients. Lancet (2012) 1.17

Gossypiboma: tales of lost sponges and lessons learned. Arch Surg (2010) 1.16

Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure. Shock (2010) 1.16

Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009. Ann Emerg Med (2010) 1.14

Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock (2011) 1.13

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient. J Trauma (2008) 1.12

Temporal trends of postinjury multiple-organ failure: still resource intensive, morbid, and lethal. J Trauma Acute Care Surg (2014) 1.11

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study. PLoS Med (2011) 1.11

Early hyperglycemia predicts multiple organ failure and mortality but not infection. J Trauma (2007) 1.09

HEMORRHAGE CONCERNS. JEMS (2015) 1.09

NIH Roundtable on Emergency Trauma Research. Ann Emerg Med (2010) 1.09

Changes in massive transfusion over time: an early shift in the right direction? J Trauma Acute Care Surg (2012) 1.07

The effect of interfacility transfer on outcome in an urban trauma system. J Trauma (2003) 1.07

Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. J Immunol (2002) 1.07

Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Ann Surg (2009) 1.06

Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuries. J Trauma (2002) 1.04

The association between the transfusion of older blood and outcomes after trauma. Shock (2011) 1.04

Acute kidney injury is associated with early cytokine changes after trauma. J Trauma Acute Care Surg (2013) 1.02

Severe traumatic injury: regional variation in incidence and outcome. Ann Surg (2010) 1.01

Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14. J Leukoc Biol (2006) 1.00

A critical assessment of the out-of-hospital trauma triage guidelines for physiologic abnormality. J Trauma (2010) 1.00

Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way. J Trauma Acute Care Surg (2012) 1.00

Limb loss following lower extremity arterial trauma: what can be done proactively? Injury (2002) 0.99

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem (2008) 0.99

Mitogen-activated protein kinase (MAPK). Crit Care Med (2005) 0.97

The delivery of critical care services in US trauma centers: is the standard being met? J Trauma (2006) 0.97

Implications of proteasome inhibition: an enhanced macrophage phenotype. Cell Immunol (2004) 0.97

Oxidative stress, lipid rafts, and macrophage reprogramming. Antioxid Redox Signal (2007) 0.97

Transfusion of red blood cells in patients with a prehospital Glasgow Coma Scale score of 8 or less and no evidence of shock is associated with worse outcomes. J Trauma Acute Care Surg (2013) 0.96

V. Guidelines for sedation and analgesia during mechanical ventilation general overview. J Trauma (2007) 0.96

The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury. J Trauma (2005) 0.95

A comparison of prehospital and hospital data in trauma patients. J Trauma (2004) 0.95

Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. Shock (2005) 0.95

Long-term outcomes of ground-level falls in the elderly. J Trauma Acute Care Surg (2014) 0.94

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients. J Am Coll Surg (2008) 0.94

Characterization of persistent hyperglycemia: what does it mean postinjury? J Trauma (2009) 0.94