Published in EMBO J on April 12, 2007
A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas. Mol Cell Proteomics (2011) 3.37
Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule. J Immunol (2008) 0.98
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. EMBO J (2014) 0.96
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis? FASEB J (2012) 0.96
The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells. J Biol Chem (2009) 0.88
ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. Chem Biol (2014) 0.82
Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out. IUBMB Life (2015) 0.78
Allele specific expression of the transthyretin gene in swedish patients with hereditary transthyretin amyloidosis (ATTR V30M) is similar between the two alleles. PLoS One (2012) 0.77
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nat Struct Mol Biol (2017) 0.75
Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction. Clin Med Insights Cardiol (2015) 0.75
Quality control in the endoplasmic reticulum. Nat Rev Mol Cell Biol (2003) 9.85
Therapeutic approaches to protein-misfolding diseases. Nature (2003) 4.57
Quality control in the endoplasmic reticulum protein factory. Nature (2003) 3.58
The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry (1996) 3.42
ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol (2002) 2.97
Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol (1999) 2.81
The biological and chemical basis for tissue-selective amyloid disease. Cell (2005) 2.76
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proc Natl Acad Sci U S A (2002) 2.25
Tabulation of human transthyretin (TTR) variants, 2003. Amyloid (2003) 2.23
Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci U S A (2004) 2.14
Trans-suppression of misfolding in an amyloid disease. Science (2001) 1.88
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry (2001) 1.85
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. Hum Mutat (2001) 1.67
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J Med Chem (2004) 1.54
Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorg Med Chem (1999) 1.38
D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry (2003) 1.36
Transthyretin: a review from a structural perspective. Cell Mol Life Sci (2001) 1.34
Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression. Mol Biol Cell (2003) 1.29
Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. Lab Invest (2003) 1.10
Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis. J Mol Biol (2005) 1.04
Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell (2005) 2.63
Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines. Clin Cancer Res (2007) 2.31
High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group. J Clin Oncol (2005) 2.24
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
A patient with medulloblastoma in its early developmental stage. J Neurosurg Pediatr (2014) 1.98
Gait disturbance due to foot drop is refractory to treatment in nonsystemic vasculitic neuropathy. Eur Neurol (2014) 1.97
Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy. Br J Haematol (2008) 1.81
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. J Biol Chem (2005) 1.68
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem (2002) 1.67
MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol (2007) 1.57
Structural basis for telmisartan-mediated partial activation of PPAR gamma. Hypertens Res (2012) 1.55
M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol (2002) 1.49
Circannual rhythm of laboratory test parameters among chronic haemodialysis patients. Blood Purif (2008) 1.48
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem (2002) 1.44
Evaluation of serological diagnosis tests for tuberculosis in hemodialysis patients. Ther Apher Dial (2006) 1.41
Establishment of novel B-cell precursor leukemia sister cell lines NALM-36 and NALM-37: shift of immunoglobulin phenotype to double light chain positive B-cell. Leuk Res (2002) 1.37
Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. J Biol Chem (2005) 1.36
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem (2002) 1.30
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J Allergy Clin Immunol (2008) 1.30
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol (2008) 1.29
Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression. Mol Biol Cell (2003) 1.29
Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression. Biochem J (2005) 1.28
The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus. J Immunol (2008) 1.26
Familial transthyretin-type amyloid polyneuropathy in Japan: clinical and genetic heterogeneity. Neurology (2002) 1.24
Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. Clin Cancer Res (2009) 1.24
Spongistatin synthetic studies. An efficient, second-generation construction of an advanced ABCD intermediate. Org Lett (2002) 1.21
Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Arch Neurol (2002) 1.19
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt. Nat Commun (2012) 1.18
Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients. Cancer Sci (2010) 1.18
Liver transplantation for familial amyloidotic polyneuropathy: impact on Swedish patients' survival. Liver Transpl (2009) 1.16
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans. Nat Immunol (2007) 1.14
Liver Transplantation for Hereditary Transthyretin Amyloidosis: After 20 Years Still the Best Therapeutic Alternative? Transplantation (2015) 1.13
Vitreous opacities and outcome of vitreous surgery in patients with familial amyloidotic polyneuropathy. Am J Ophthalmol (2003) 1.12
Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem (2008) 1.12
Secondary glaucoma in patients with familial amyloidotic polyneuropathy. Arch Ophthalmol (2003) 1.12
Cellular immune profile in patients with non-small cell lung cancer after weekly paclitaxel therapy. Acta Oncol (2004) 1.11
Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland. Diagn Cytopathol (2011) 1.09
The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome. Cancer Res (2002) 1.09
Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. PLoS One (2008) 1.08
Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling. Am J Physiol Lung Cell Mol Physiol (2007) 1.07
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene (2004) 1.06
Ocular amyloid angiopathy associated with familial amyloidotic polyneuropathy caused by amyloidogenic transthyretin Y114C. Ophthalmology (2005) 1.05
Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli. Glycobiology (2002) 1.05
Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study. Mod Pathol (2011) 1.04
Biosensor discovery of thyroxine transport disrupting chemicals. Toxicol Appl Pharmacol (2008) 1.04
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. Mol Cell (2012) 1.04
Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1. Tetrahedron (2009) 1.04
Hyperthermia with mild electrical stimulation protects pancreatic β-cells from cell stresses and apoptosis. Diabetes (2012) 1.03
The NMR structure of stomagen reveals the basis of stomatal density regulation by plant peptide hormones. Nat Commun (2011) 1.03
Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. Haematologica (2008) 1.02
A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol (2009) 1.01
Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK. Biochem Biophys Res Commun (2008) 1.00
Amyloid deposition in ocular tissues of patients with familial amyloidotic polyneuropathy (FAP). Amyloid (2002) 0.99
Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy. J Hum Genet (2006) 0.99
Steryl glucoside is a lipid mediator in stress-responsive signal transduction. Cell Struct Funct (2002) 0.99
Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma. J Pathol (2011) 0.98
Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis. Amyloid (2013) 0.98
Midkine in plasma as a novel breast cancer marker. Cancer Sci (2009) 0.98
Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator. J Biol Chem (2006) 0.98
Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells. Ann Surg Oncol (2010) 0.98
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem (2012) 0.98
The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. Biochemistry (2010) 0.97
Structure of the central hub of bacteriophage Mu baseplate determined by X-ray crystallography of gp44. J Mol Biol (2005) 0.96
Primary tumor induces sentinel lymph node lymphangiogenesis in oral squamous cell carcinoma. Oral Oncol (2010) 0.95
Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin. J Struct Biol (2012) 0.95
State of the art: Transforaminal approach for percutaneous endoscopic lumbar discectomy under local anesthesia. J Med Invest (2014) 0.95
Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts. Int J Cancer (2012) 0.95
TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. Cancer Sci (2010) 0.95
Aging and transthyretin-related amyloidosis: pathologic examinations in pulmonary amyloidosis. Amyloid (2006) 0.95
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies. J Gen Virol (2004) 0.95
Maternal death analysis from the Japanese autopsy registry for recent 16 years: significance of amniotic fluid embolism. J Obstet Gynaecol Res (2010) 0.95