Published in Genes Brain Behav on April 19, 2007
Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry (2015) 2.07
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci Biobehav Rev (2008) 1.65
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry (2009) 1.55
Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol (2008) 1.48
Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov (2010) 1.47
Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Biol Psychiatry (2011) 1.47
Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Hum Mol Genet (2009) 1.39
CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci (2010) 1.38
Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans. J Neurosci (2009) 1.26
The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Hum Mol Genet (2008) 1.23
Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects. Int J Neuropsychopharmacol (2012) 1.19
Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics (2009) 1.10
The role of serotonin receptor subtypes in treating depression: a review of animal studies. Psychopharmacology (Berl) (2010) 1.08
(1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. Eur J Pharmacol (2009) 1.05
Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology (2011) 1.03
S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology (Berl) (2008) 1.00
Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviors. Neuropharmacology (2010) 0.99
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder. Behav Pharmacol (2009) 0.96
Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis. Neuropsychopharmacology (2015) 0.95
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature (2016) 0.93
Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans. J Neurosci (2012) 0.92
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse. Alcohol (2012) 0.91
Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. Eur J Neurosci (2009) 0.89
Affect-related behaviors in mice misexpressing the RNA editing enzyme ADAR2. Physiol Behav (2009) 0.89
Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress. Neuroscience (2012) 0.89
5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior. Neuroscience (2011) 0.89
Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward. Front Neurosci (2013) 0.87
Anxiolytic effects of 5-HT₁A receptors and anxiogenic effects of 5-HT₂C receptors in the amygdala of mice. Neuropharmacology (2011) 0.85
Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients. J Inherit Metab Dis (2012) 0.85
Neuropeptide regulation of signaling and behavior in the BNST. Mol Cells (2014) 0.85
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry (2011) 0.84
Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience (2010) 0.84
5-HT2CR blockade in the amygdala conveys analgesic efficacy to SSRIs in a rat model of arthritis pain. Mol Pain (2013) 0.84
Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. ACS Chem Neurosci (2012) 0.81
Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties. Br J Pharmacol (2014) 0.80
A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters. Behav Neurosci (2012) 0.80
Tracheal occlusion conditioning in conscious rats modulates gene expression profile of medial thalamus. Front Physiol (2011) 0.79
Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood. Eur J Neurosci (2014) 0.78
Ethanol induced adaptations in 5-HT2c receptor signaling in the bed nucleus of the stria terminalis: implications for anxiety during ethanol withdrawal. Neuropharmacology (2014) 0.78
Quetiapine-induced sleep-related eating disorder-like behavior: a case series. J Med Case Rep (2012) 0.78
Serotonin receptors in depression: from A to B. F1000Res (2017) 0.77
Rapid birth-and-death evolution of imprinted snoRNAs in the Prader-Willi syndrome locus: implications for neural development in Euarchontoglires. PLoS One (2014) 0.77
Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration. Surg Neurol Int (2014) 0.77
5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence. Int J Neuropsychopharmacol (2014) 0.77
5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech (2016) 0.77
Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females. Psychoneuroendocrinology (2015) 0.76
Input-specific contributions to valence processing in the amygdala. Learn Mem (2016) 0.76
Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.75
Pharmacogenetics informed decision making in adolescent psychiatric treatment: a clinical case report. Int J Mol Sci (2015) 0.75
Hippocampal serotonin-2A receptor-immunoreactive neurons density increases after testosterone therapy in the gonadectomized male mice. Anat Cell Biol (2016) 0.75
Analysis of the Serotonergic System in a Mouse Model of Rett Syndrome Reveals Unusual Upregulation of Serotonin Receptor 5b. Front Mol Neurosci (2017) 0.75
CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia. Sci Rep (2016) 0.75
Blonanserin - A Novel Antianxiety and Antidepressant Drug? An Experimental Study. J Clin Diagn Res (2016) 0.75
Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. J Abnorm Psychol (2015) 0.75
5-HT2C receptor knockdown in the amygdala inhibits neuropathic pain related plasticity and behaviors. J Neurosci (2016) 0.75
A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates. Curr Neuropharmacol (2015) 0.75
Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry (2016) 0.75
Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plast (2015) 0.75
5-HT2C receptors in the BNST are necessary for the enhancement of fear learning by selective serotonin reuptake inhibitors. Neurobiol Learn Mem (2016) 0.75
The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo. Front Pharmacol (2015) 0.75
Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders. Gastroenterol Res Pract (2017) 0.75
Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex. Front Neuroanat (2017) 0.75
Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse. Mol Metab (2017) 0.75
A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment. Psychopharmacology (Berl) (2017) 0.75
Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science (1996) 41.35
The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 34.00
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature (1997) 14.38
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
Hexokinase as a sugar sensor in higher plants. Plant Cell (1997) 4.89
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity (1995) 3.99
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83
Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. Genes Dev (2000) 3.42
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet (1997) 3.20
Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol (2011) 3.07
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci (1995) 2.94
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med (1998) 2.89
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A (2001) 2.84
Sugars as signaling molecules. Curr Opin Plant Biol (1999) 2.62
Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. EMBO J (2000) 2.56
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A (1996) 2.48
A family of positive regulators related to the Pseudomonas putida TOL plasmid XylS and the Escherichia coli AraC activators. Nucleic Acids Res (1990) 2.48
The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev (1994) 2.47
Carbon and nitrogen sensing and signaling in plants: emerging 'matrix effects'. Curr Opin Plant Biol (2001) 2.37
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell (1999) 2.35
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci U S A (1998) 2.27
Culture, risk factors and suicide in rural China: a psychological autopsy case control study. Acta Psychiatr Scand (2004) 2.24
Mutagenesis of the N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine DNA adduct in mammalian cells. Sequence context effects. J Biol Chem (1999) 2.17
A large carbon sink in the woody biomass of Northern forests. Proc Natl Acad Sci U S A (2001) 2.02
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 1.97
Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes. Gene (1995) 1.94
Diet, physical activity, and colorectal cancer among Chinese in North America and China. J Natl Cancer Inst (1990) 1.92
Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood (2000) 1.91
Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron (1993) 1.88
Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A (1997) 1.88
The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol (1999) 1.87
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res (2001) 1.81
PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. Biochem Biophys Res Commun (1999) 1.76
Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J Biol Chem (1996) 1.75
Natural history of Streptococcus sanguinis in the oral cavity of infants: evidence for a discrete window of infectivity. Infect Immun (2000) 1.75
Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis (2006) 1.74
The pattern of disulfide linkages in the extracellular loop regions of connexin 32 suggests a model for the docking interface of gap junctions. J Cell Biol (1998) 1.73
CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia. Hum Mol Genet (1999) 1.72
Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest (1997) 1.72
Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A (1996) 1.71
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol (1999) 1.69
The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J Biol Chem (1999) 1.59
P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol (2000) 1.55
Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost (1996) 1.53
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem (1989) 1.52
Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1999) 1.50
Construction and analysis of compact muscle-specific promoters for AAV vectors. Gene Ther (2008) 1.48
Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes. Proc Natl Acad Sci U S A (1991) 1.47
Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl) (1999) 1.47
Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol Cell Biol (2001) 1.46
Regulation of vascular endothelial growth factor expression by insulin-like growth factor I. Diabetes (1997) 1.45
Simultaneous stochastic sensing of divalent metal ions. Nat Biotechnol (2000) 1.44
Translation and psychometric evaluation of a Chinese version of the SF-36 Health Survey in the United States. J Clin Epidemiol (1998) 1.44
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors. Am J Transplant (2013) 1.44
Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Neuron (1999) 1.44
The immunogenicity, safety, and efficacy of etanercept liquid administered once weekly in patients with rheumatoid arthritis. Clin Exp Rheumatol (2007) 1.41
Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol (2009) 1.40
Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. J Clin Endocrinol Metab (1991) 1.39
Parameters from preoperative overnight oximetry predict postoperative adverse events. Minerva Anestesiol (2014) 1.39
[Experimental study on decoctum Agrimonia pilosa Ledeb-induced apoptosis in HL-60 cells in vitro]. Zhong Yao Cai (2000) 1.39
Comparison of dietary habits, physical activity and body size among Chinese in North America and China. Int J Epidemiol (1994) 1.37
Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. Int J Cancer (2000) 1.37
Sustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks. Ann Rheum Dis (2005) 1.35
Plant-derived bioactive compounds produced by endophytic fungi. Mini Rev Med Chem (2011) 1.35
Arthroscopic microdiscectomy and selective fragmentectomy. Clin Orthop Relat Res (1998) 1.32
Mixed modelling to characterize genotype-phenotype associations. Stat Med (2005) 1.31
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene (2011) 1.30
Reduced rates of skeletal remodeling are associated with increased bone mineral density during the development of peak skeletal mass. J Bone Miner Res (1997) 1.29
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet (2000) 1.26
Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr. J Neurocytol (2000) 1.26
From mitochondrial dynamics to arrhythmias. Int J Biochem Cell Biol (2009) 1.26
Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol (2001) 1.24
Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes. Cell Death Differ (1998) 1.20
Transforaminal arthroscopic decompression of lateral recess stenosis. J Neurosurg (1996) 1.20
The structure of a highly virulent Theiler's murine encephalomyelitis virus (GDVII) and implications for determinants of viral persistence. Virology (1996) 1.20
Immunoreactivity of central vasopressin and oxytocin pathways in microtine rodents: a quantitative comparative study. J Comp Neurol (1996) 1.18
Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C. Hum Mutat (1999) 1.16
Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci U S A (1995) 1.16
Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation. Transplant Proc (2007) 1.15
Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension (1999) 1.15
Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. Chin Med J (Engl) (2001) 1.15
Regulation of Nod1-mediated signaling pathways. Cell Death Differ (2006) 1.15
Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). Genomics (2000) 1.14
Cryptosporidium suis n. sp. (Apicomplexa: Cryptosporidiidae) in pigs (Sus scrofa). J Parasitol (2004) 1.14
Post-transcriptional regulation of the arginine transporter Cat-1 by amino acid availability. J Biol Chem (1999) 1.14
Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma. Oncogene (2011) 1.13
Chinese herbal medicine suxiao jiuxin wan for angina pectoris. Cochrane Database Syst Rev (2008) 1.13
Hepatocytes contribute to soluble CD14 production, and CD14 expression is differentially regulated in hepatocytes and monocytes. J Biol Chem (2000) 1.12
Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3. Neuron (1997) 1.12
Genome-wide identification of quantitative trait loci for carcass composition and meat quality in a large-scale White Duroc x Chinese Erhualian resource population. Anim Genet (2009) 1.12
Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem (2000) 1.11
Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours. Br J Cancer (2004) 1.11