Published in JAMA on April 25, 2007
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35
Age-related macular degeneration. Lancet (2008) 3.34
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci (2008) 2.91
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol (2010) 2.32
Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography. Ophthalmology (2010) 1.93
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Smoking, dietary betaine, methionine, and vitamin D in monozygotic twins with discordant macular degeneration: epigenetic implications. Ophthalmology (2011) 1.81
Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology (2009) 1.80
Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. Ophthalmology (2011) 1.61
Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol (2008) 1.47
Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci (2008) 1.47
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
The role of the complement system in age-related macular degeneration. Dtsch Arztebl Int (2014) 1.34
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS One (2009) 1.34
Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 1.30
C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PLoS One (2008) 1.22
Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. Hum Mol Genet (2008) 1.20
Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration. PLoS One (2009) 1.19
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. Am J Ophthalmol (2010) 1.19
Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology (2010) 1.18
The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci. Hum Genet (2008) 1.18
Involvement of genetic factors in the response to a variable-dosing ranibizumab treatment regimen for age-related macular degeneration. Mol Vis (2010) 1.17
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One (2013) 1.16
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology (2012) 1.16
Mechanism of inflammation in age-related macular degeneration. Mediators Inflamm (2012) 1.14
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application. Graefes Arch Clin Exp Ophthalmol (2010) 1.12
Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators Inflamm (2010) 1.11
Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel. Mol Vis (2008) 1.10
Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. Arch Ophthalmol (2011) 1.10
Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Mol Vis (2010) 1.08
The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology (2008) 1.07
Genetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease management. Ophthalmology (2012) 1.07
The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization. Am J Pathol (2010) 1.06
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS One (2008) 1.03
Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Arch Ophthalmol (2010) 1.02
Genetic contributions to the development of retinopathy of prematurity. Pediatr Res (2009) 1.01
Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. PLoS One (2014) 0.99
Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration. Drug Des Devel Ther (2013) 0.99
rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One (2009) 0.97
Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet (2013) 0.97
Age-related macular degeneration and the aging eye. Clin Interv Aging (2008) 0.96
Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort. Am J Epidemiol (2008) 0.95
Three new genetic loci (R1210C in CFH, variants in COL8A1 and RAD51B) are independently related to progression to advanced macular degeneration. PLoS One (2014) 0.94
Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. Invest Ophthalmol Vis Sci (2015) 0.94
Kidney function, albuminuria and age-related macular degeneration in NHANES III. Nephrol Dial Transplant (2011) 0.93
Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study. Arch Ophthalmol (2012) 0.93
Lifestyle exposures and eye diseases in adults. Am J Ophthalmol (2007) 0.93
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology (2010) 0.92
Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study. BMC Med Genet (2013) 0.91
Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. Mol Vis (2010) 0.91
Development of a risk score for geographic atrophy in complications of the age-related macular degeneration prevention trial. Ophthalmology (2011) 0.88
Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration. Mol Vis (2010) 0.87
Genetic and environmental underpinnings to age-related ocular diseases. Invest Ophthalmol Vis Sci (2013) 0.85
Peroxisome proliferator-activated receptor and age-related macular degeneration. PPAR Res (2008) 0.84
Persons with age-related maculopathy risk genotypes and clinically normal eyes have reduced mesopic vision. Invest Ophthalmol Vis Sci (2011) 0.84
New era for personalized medicine: the diagnosis and management of age-related macular degeneration. Clin Experiment Ophthalmol (2009) 0.83
Genetic analysis of simultaneous geographic atrophy and choroidal neovascularization. Eye (Lond) (2012) 0.83
Update on the role of genetics in the onset of age-related macular degeneration. Clin Ophthalmol (2011) 0.83
Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population. Jpn J Ophthalmol (2011) 0.82
The relationship between BCMO1 gene variants and macular pigment optical density in persons with and without age-related macular degeneration. PLoS One (2014) 0.82
Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review. Drug Des Devel Ther (2016) 0.82
A pharmacogenetics study to predict outcome in patients receiving anti-VEGF therapy in age related macular degeneration. Clin Ophthalmol (2013) 0.81
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81
Genotype-based risk and pharmacogenetic sampling in clinical trials. J Biopharm Stat (2010) 0.81
DNA damage/repair and polymorphism of the hOGG1 gene in lymphocytes of AMD patients. J Biomed Biotechnol (2009) 0.81
Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions. Genet Epidemiol (2016) 0.80
Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. Cell Mol Life Sci (2014) 0.80
Complement Factor H Y402H and LOC387715 A69S Polymorphisms in Association with Age-Related Macular Degeneration in Iran. J Ophthalmic Vis Res (2014) 0.79
Misclassification can explain most apparent regression of age-related macular degeneration: results from multistate models with misclassification. Invest Ophthalmol Vis Sci (2014) 0.79
Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes. Invest Ophthalmol Vis Sci (2015) 0.79
Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis. Sci Rep (2015) 0.78
Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. Invest Ophthalmol Vis Sci (2016) 0.77
Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk. Invest Ophthalmol Vis Sci (2016) 0.77
Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration. Mol Biol Rep (2012) 0.77
Genetic variation and its role in malignancy. Int J Biomed Sci (2011) 0.77
Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One (2016) 0.76
Gene-gene interaction of CFH, ARMS2, and ARMS2/HTRA1 on the risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese population. Eye (Lond) (2015) 0.76
Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Genetics (2017) 0.75
Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. PLoS One (2015) 0.75
[Age-related macular degeneration and risk of stroke]. J Fr Ophtalmol (2008) 0.75
Tumor Necrosis Factor Gene Polymorphisms in Advanced Non-exudative Age-related Macular Degeneration. J Ophthalmic Vis Res (2015) 0.75
Genetic associations with age-related macular degeneration. JAMA (2007) 0.75
The Status of Maculopathy in Diabetes and Prediabetes Patients in a Population-Based Study Detected by Optical Coherence Tomography: The 2011 Health Examination Survey in Beijing. Biomed Res Int (2017) 0.75
Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci (2017) 0.75
[Genetic and risk factors for exudative AMD]. Ophthalmologe (2010) 0.75
Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population. Clin Ophthalmol (2017) 0.75
A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep (2017) 0.75
[Clinical characteristics, progression and risk factors of geographic atrophy]. Ophthalmologe (2010) 0.75
Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst (2004) 8.77
Extended work shifts and the risk of motor vehicle crashes among interns. N Engl J Med (2005) 8.73
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. N Engl J Med (1990) 4.77
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA (2011) 4.25
Frequency of analgesic use and risk of hypertension in younger women. Arch Intern Med (2002) 4.21
Association between C-reactive protein and age-related macular degeneration. JAMA (2004) 4.16
Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol (2005) 4.04
Comparison of risk factors for colon and rectal cancer. Int J Cancer (2004) 4.03
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Relation between dieting and weight change among preadolescents and adolescents. Pediatrics (2003) 3.36
Extended work duration and the risk of self-reported percutaneous injuries in interns. JAMA (2006) 3.26
Impact of extended-duration shifts on medical errors, adverse events, and attentional failures. PLoS Med (2006) 3.22
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science (2014) 3.14
Adult weight change and risk of postmenopausal breast cancer. JAMA (2006) 3.11
Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. Am J Epidemiol (2005) 3.02
Age-related macular degeneration--a genome scan in extended families. Am J Hum Genet (2003) 2.99
Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci (2008) 2.91
CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology (2008) 2.90
Molecular genetic basis of inherited cataract and associated phenotypes. Surv Ophthalmol (2004) 2.85
Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT). Ophthalmology (2013) 2.82
Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol (2010) 2.78
Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genet (2003) 2.72
Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr (2003) 2.68
Serum lipids, lipid-lowering drugs, and the risk of breast cancer. Arch Intern Med (2005) 2.66
Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum Gene Ther (2006) 2.59
Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol (2003) 2.50
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet (2005) 2.34
Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. Am J Clin Nutr (2003) 2.29
Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy. Arch Ophthalmol (2011) 2.27
ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol (2012) 2.23
Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch Ophthalmol (2006) 2.21
Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Ophthalmol (2003) 2.20
Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med (2010) 2.15
Town-level characteristics and smoking policy adoption in Massachusetts: are local restaurant smoking regulations fostering disparities in health protection? Am J Public Health (2004) 2.14
Epidemiology of urinary melatonin in women and its relation to other hormones and night work. Cancer Epidemiol Biomarkers Prev (2004) 2.10
Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol (2005) 2.08
Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nat Mater (2004) 2.07
Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect (2004) 2.06
Association of Fecundity With Changes in Adult Female Weight. Obstet Gynecol (2015) 1.97
De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A (2002) 1.95
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2009) 1.93
Healthful dietary patterns and type 2 diabetes mellitus risk among women with a history of gestational diabetes mellitus. Arch Intern Med (2012) 1.92
Lifetime nonnarcotic analgesic use and decline in renal function in women. Arch Intern Med (2004) 1.91
Functional impact of breast cancer by age at diagnosis. J Clin Oncol (2004) 1.91
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence. J Clin Oncol (2012) 1.85
Gestational vitamin D and the risk of multiple sclerosis in offspring. Ann Neurol (2011) 1.85
Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr (2012) 1.84
Smoking, dietary betaine, methionine, and vitamin D in monozygotic twins with discordant macular degeneration: epigenetic implications. Ophthalmology (2011) 1.81
The validity of self-reported weight change among adolescents and young adults. Obesity (Silver Spring) (2007) 1.81
Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. Arch Ophthalmol (2004) 1.80
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Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res (2005) 1.77
A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer (2007) 1.76
Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. J Natl Cancer Inst (2011) 1.75
Risk assessment model for development of advanced age-related macular degeneration. Arch Ophthalmol (2011) 1.75
NHANES monitoring of serum 25-hydroxyvitamin D: a roundtable summary. J Nutr (2010) 1.74
Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med (2006) 1.74
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry (2010) 1.73
Use of postmenopausal hormones, alcohol, and risk for invasive breast cancer. Ann Intern Med (2002) 1.73
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol (2012) 1.72
Statins, fibrates, and ocular myasthenia. Lancet (2002) 1.71
Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. Arch Ophthalmol (2004) 1.71
Plasma prolactin concentrations and risk of postmenopausal breast cancer. Cancer Res (2004) 1.67
Job stress and breast cancer risk: the nurses' health study. Am J Epidemiol (2004) 1.66
Probing the structure of DNA-carbon nanotube hybrids with molecular dynamics. Nano Lett (2007) 1.65
A novel diagnostic test detects a low frequency of the hemicentin Gln5345Arg variant among Northern Irish age related macular degeneration patients. Mol Vis (2004) 1.64
Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol (2004) 1.63
Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. Invest Ophthalmol Vis Sci (2012) 1.63
Understanding nature's design for a nanosyringe. Proc Natl Acad Sci U S A (2004) 1.62
CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered (2006) 1.62
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol Pharm (2006) 1.61
Embedded cholesterol in the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (2008) 1.61
Risk factors for mortality in the nurses' health study: a competing risks analysis. Am J Epidemiol (2010) 1.61
Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. Ophthalmology (2011) 1.61
Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules. J Am Chem Soc (2010) 1.59
Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures. Science (2010) 1.59
Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat (2011) 1.58
Lung cancer and vehicle exhaust in trucking industry workers. Environ Health Perspect (2008) 1.57
Computer simulation studies of model biological membranes. Acc Chem Res (2002) 1.56
Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up. Am J Epidemiol (2006) 1.55
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