PubRank

Jeffrey S Flier

Author PubWeight™ 126.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006 17.49
2 Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004 11.94
3 Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007 9.34
4 FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 2012 5.71
5 Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006 4.53
6 Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004 4.10
7 Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005 4.01
8 Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010 3.30
9 Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004 2.98
10 Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology 2009 2.89
11 Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 2007 2.54
12 Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 2006 2.52
13 Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes 2006 2.50
14 The gut and energy balance: visceral allies in the obesity wars. Science 2005 2.24
15 Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004 2.12
16 Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem 2004 2.11
17 The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 2007 2.02
18 Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology 2011 2.00
19 Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol 2007 1.96
20 Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab 2006 1.96
21 Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003 1.95
22 Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest 2011 1.89
23 Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A 2008 1.83
24 Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem 2004 1.75
25 Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem 2009 1.63
26 Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 2007 1.63
27 PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab 2007 1.61
28 Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science 2011 1.60
29 Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine. Proc Natl Acad Sci U S A 2009 1.45
30 Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A 2003 1.41
31 Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes 2005 1.40
32 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 2002 1.37
33 Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002 1.36
34 Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem 2006 1.35
35 Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A 2007 1.35
36 Neuroscience. The fat-brain axis enters a new dimension. Science 2004 1.33
37 Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 2006 1.30
38 Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 2008 1.29
39 Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes 2002 1.29
40 Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 2003 1.22
41 Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem 2010 1.16
42 The stomach speaks--ghrelin and weight regulation. N Engl J Med 2002 1.09
43 Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord 2003 1.03
44 Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes 2010 1.01
45 Creating a Nobel culture. Science 2013 0.96
46 Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes 2003 0.94
47 Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes 2004 0.93
48 Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. Endocrinology 2009 0.91
49 Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes 2011 0.90
50 A good night's sleep: future antidote to the obesity epidemic? Ann Intern Med 2004 0.84
51 Physiology: is brain sympathetic to bone? Nature 2002 0.80
52 Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology 2014 0.80