Published in Biochemistry on May 16, 2007
Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol (2009) 1.45
An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation). BMC Bioinformatics (2009) 1.43
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol (2010) 1.21
Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene (2014) 1.13
Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation. J Immunol (2010) 1.10
Tissue factor and PAR2 signaling in the tumor microenvironment. Arterioscler Thromb Vasc Biol (2009) 1.09
MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem (2013) 1.07
Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol (2009) 1.05
Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Front Mol Neurosci (2009) 1.05
The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55. J Biol Chem (2012) 1.05
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem (2013) 0.99
H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury. Proc Natl Acad Sci U S A (2012) 0.98
Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med (2014) 0.94
G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell (2009) 0.93
Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals (2009) 0.93
Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal (2009) 0.90
Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes. Curr Mol Med (2009) 0.88
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells. Mol Cancer (2015) 0.88
PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA. J Cell Sci (2013) 0.86
Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer (2013) 0.85
Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway. J Biol Chem (2010) 0.84
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2. J Mol Signal (2014) 0.83
S-nitrosylation-regulated GPCR signaling. Biochim Biophys Acta (2011) 0.83
The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem (2011) 0.83
The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Mol Pharmacol (2008) 0.83
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS One (2011) 0.82
Cellular mechanisms of the 5-HT7 receptor-mediated signaling. Front Behav Neurosci (2014) 0.82
Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction. Oncotarget (2015) 0.82
Heat-shock factor 2 is a suppressor of prostate cancer invasion. Oncogene (2015) 0.80
Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key. Front Genet (2013) 0.79
Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling. J Biol Chem (2015) 0.79
GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. Blood (2016) 0.78
Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling. J Mol Signal (2013) 0.78
Regulation of integrin expression by Gα12: An additional potential mechanism modulating cell attachment. Cell Adh Migr (2010) 0.77
Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation. Mol Pharmacol (2014) 0.77
Osteoclastogenic activity and RANKL expression are inhibited in osteoblastic cells expressing constitutively active Gα(12) or constitutively active RhoA. J Cell Biochem (2010) 0.76
GNA13 as a prognostic factor and mediator of gastric cancer progression. Oncotarget (2016) 0.76
Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene (2015) 0.76
Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal (2015) 0.75
Molecular Cloning and Characterization of G Alpha Proteins from the Western Tarnished Plant Bug, Lygus hesperus. Insects (2014) 0.75
G Protein-Coupled Receptors in Cancer. Int J Mol Sci (2016) 0.75
Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells. J Biol Chem (2015) 0.75
Post-prenylation-processing enzymes as new targets in oncogenesis. Nat Rev Cancer (2005) 2.47
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell (2005) 2.36
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol (2004) 2.15
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest (2004) 1.81
Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res (2010) 1.77
Reaction path of protein farnesyltransferase at atomic resolution. Nature (2002) 1.63
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A (2005) 1.59
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol (2002) 1.56
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem (2006) 1.47
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest (2007) 1.47
Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem (2004) 1.43
Activation of Rap1 promotes prostate cancer metastasis. Cancer Res (2009) 1.41
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. J Biol Chem (2006) 1.35
A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem (2008) 1.32
Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J (2003) 1.28
Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem (2005) 1.26
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell (2005) 1.23
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A (2003) 1.17
Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol Cell Neurosci (2005) 1.16
Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem (2002) 1.14
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem (2003) 1.10
MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem (2013) 1.07
Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol (2009) 1.05
Galphaz negatively regulates insulin secretion and glucose clearance. J Biol Chem (2007) 1.03
Selective uncoupling of G alpha 12 from Rho-mediated signaling. J Biol Chem (2005) 1.03
Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal (2009) 1.01
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry (2003) 1.00
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem (2004) 0.99
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt). BMC Biochem (2004) 0.98
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. J Biol Chem (2009) 0.97
Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. J Biol Chem (2002) 0.96
Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. J Am Coll Surg (2006) 0.95
Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry (2006) 0.94
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. J Biol Chem (2003) 0.94
Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther (2010) 0.92
RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. Cell Adh Migr (2011) 0.91
The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Mol Pharmacol (2006) 0.91
A global partnership in medical education between Duke University and the National University of Singapore. Acad Med (2008) 0.91
Endoscopically assisted fasciotomy: description of technique and in vitro assessment of lower-leg compartment decompression. Am J Sports Med (2002) 0.91
A role for Rac3 GTPase in the regulation of autophagy. J Biol Chem (2011) 0.90
Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem (2011) 0.90
Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Mol Pharmacol (2004) 0.89
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Mol Cell Biol (2009) 0.88
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol (2006) 0.88
Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. J Biol Chem (2012) 0.87
A role for G(z) in pancreatic islet beta-cell biology. J Biol Chem (2005) 0.87
The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. J Vasc Surg (2010) 0.86
G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. J Biol Chem (2005) 0.86
Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A? Mol Pharmacol (2007) 0.86
Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. Theriogenology (2002) 0.86
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem (2002) 0.86
Two regions of cadherin cytoplasmic domains are involved in suppressing motility of a mammary carcinoma cell line. J Biol Chem (2003) 0.84
A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. J Biol Chem (2010) 0.84
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. J Med Chem (2009) 0.84
Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. Biochemistry (2004) 0.83
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. Biochemistry (2007) 0.83
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. J Biol Chem (2010) 0.82
Control of RhoA methylation by carboxylesterase I. J Biol Chem (2013) 0.82
Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Invest Ophthalmol Vis Sci (2008) 0.82
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS One (2011) 0.82
Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis. Cell Signal (2010) 0.82
PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. Am J Surg (2009) 0.80
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem (2013) 0.80
Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling. J Mol Signal (2013) 0.78
Gα(12) binds to the N-terminal regulatory domain of p120(ctn), and downregulates p120(ctn) tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism. Exp Cell Res (2010) 0.78
Interacting targets of the farnesyl of transducin gamma-subunit. Biochemistry (2008) 0.78
Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. J Med Chem (2010) 0.78
Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. J Biol Chem (2002) 0.78
Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. J Comb Chem (2004) 0.78
Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation. Mol Pharmacol (2014) 0.77
The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. J Biol Chem (2002) 0.76
The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes. Zygote (2011) 0.76
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett (2006) 0.75
Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Methods Enzymol (2004) 0.75