Published in J Biol Chem on May 16, 2007
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Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis. J Biol Chem (2008) 1.59
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry (2010) 1.20
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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation. Curr Opin Biotechnol (2011) 1.07
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A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin. Mol Microbiol (2008) 1.03
A conserved C-terminal 13-amino-acid motif of Gap1 is required for Gap1 function and necessary for the biogenesis of a serine-rich glycoprotein of Streptococcus parasanguinis. Infect Immun (2008) 0.99
Structural and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesins. J Biol Chem (2011) 0.98
New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. J Biol Chem (2009) 0.97
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases. J Biol Chem (2012) 0.96
Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis. J Biol Chem (2009) 0.93
Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem (2014) 0.90
Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. Proc Natl Acad Sci U S A (2012) 0.90
Domain organization of the polymerizing mannosyltransferases involved in synthesis of the Escherichia coli O8 and O9a lipopolysaccharide O-antigens. J Biol Chem (2012) 0.89
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Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus. J Mol Biol (2010) 0.87
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The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo. J Bacteriol (2014) 0.85
Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase. J Biol Chem (2008) 0.85
Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria. J Biol Chem (2013) 0.84
Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria. PLoS One (2012) 0.84
Massive formation of intracellular membrane vesicles in Escherichia coli by a monotopic membrane-bound lipid glycosyltransferase. J Biol Chem (2009) 0.83
Tryptophan residues promote membrane association for a plant lipid glycosyltransferase involved in phosphate stress. J Biol Chem (2010) 0.83
Expression, purification, crystallization and preliminary X-ray characterization of a putative glycosyltransferase of the GT-A fold found in mycobacteria. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.83
Role of PelF in pel polysaccharide biosynthesis in Pseudomonas aeruginosa. Appl Environ Microbiol (2013) 0.82
Biochemical and biophysical characterization of the sialyl-/hexosyltransferase synthesizing the meningococcal serogroup W135 heteropolysaccharide capsule. J Biol Chem (2013) 0.82
Domain interactions control complex formation and polymerase specificity in the biosynthesis of the Escherichia coli O9a antigen. J Biol Chem (2014) 0.81
Both GtfA and GtfB are required for SraP glycosylation in Staphylococcus aureus. Curr Microbiol (2014) 0.81
Crystal structure of a virus-encoded putative glycosyltransferase. J Virol (2010) 0.80
Small molecules containing hetero-bicyclic ring systems compete with UDP-Glc for binding to WaaG glycosyltransferase. Glycoconj J (2012) 0.80
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria. J Biol Chem (2012) 0.78
Purification, crystallization and preliminary crystallographic analysis of WsaF, an essential rhamnosyltransferase from Geobacillus stearothermophilus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nat Commun (2016) 0.76
Learning from the past for TB drug discovery in the future. Drug Discov Today (2016) 0.76
Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside. Protein Expr Purif (2014) 0.76
Riemerella anatipestifer M949_1360 Gene Functions on the Lipopolysaccharide Biosynthesis and Bacterial Virulence. PLoS One (2016) 0.75
The structure of WbnH in a near active state. Protein Cell (2015) 0.75
Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria. J Biol Chem (2016) 0.75
Complete Tetrasaccharide Repeat Unit Biosynthesis of the Immunomodulatory Bacteroides fragilis Capsular Polysaccharide A. ACS Chem Biol (2016) 0.75
Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids. Microbiol Spectr (2014) 0.75
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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science (2009) 3.39
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A randomised trial to compare the pharmacokinetic, pharmacodynamic, and antiviral effects of peginterferon alfa-2b and peginterferon alfa-2a in patients with chronic hepatitis C (COMPARE). J Hepatol (2006) 3.31
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog (2009) 2.76
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques. PLoS One (2009) 2.49
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Mycobacterium abscessus: a new antibiotic nightmare. J Antimicrob Chemother (2012) 2.43
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol (2012) 2.40
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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med (2013) 2.19
Is adipose tissue a place for Mycobacterium tuberculosis persistence? PLoS One (2006) 2.18
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol (2009) 2.00
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog (2008) 1.94
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Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS One (2008) 1.91
The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology (2007) 1.89
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Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Mol Microbiol (2002) 1.84
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. PLoS Pathog (2007) 1.83
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. J Biol Chem (2002) 1.80
PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS One (2008) 1.79
The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs. Vaccine (2006) 1.77
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. J Clin Invest (2004) 1.76
The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J Biol Chem (2005) 1.74
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. Tuberculosis (Edinb) (2005) 1.73
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (2012) 1.73
The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J Biol Chem (2002) 1.70
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol (2003) 1.69
A clinical pathway for bronchiolitis is effective in reducing readmission rates. J Pediatr (2005) 1.68
Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol (2009) 1.64
Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis. PLoS One (2008) 1.62
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis. J Biol Chem (2003) 1.62
Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family. J Clin Microbiol (2008) 1.59
Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe (2011) 1.59
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation. EMBO J (2004) 1.58
Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis. J Biol Chem (2003) 1.52
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons. Free Radic Biol Med (2006) 1.50
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Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis. Microbiology (2003) 1.48
Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol (2008) 1.48
Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Mol Biol Evol (2007) 1.47
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis. Mol Biol Evol (2006) 1.46
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Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc Natl Acad Sci U S A (2009) 1.45
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLoS Pathog (2010) 1.45
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med (2006) 1.42
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell (2002) 1.42
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure (2004) 1.42
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. Mol Microbiol (2008) 1.40
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A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J Bacteriol (2007) 1.38
After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection. Genome Res (2012) 1.38
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J (2006) 1.37
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol (2002) 1.36
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J Biol Chem (2003) 1.32
Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method. Infect Genet Evol (2010) 1.32
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis. EMBO J (2006) 1.31
The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface. Tuberculosis (Edinb) (2008) 1.31
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials. Vaccine (2013) 1.31
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. EMBO J (2006) 1.31
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase. Proc Natl Acad Sci U S A (2006) 1.30
DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis. PLoS Med (2005) 1.30
Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol Microbiol (2002) 1.28
The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region. Am J Hum Genet (2005) 1.28
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth. J Bacteriol (2006) 1.27
Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA (2010) 1.26
Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair. PLoS One (2011) 1.26
Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Antimicrob Agents Chemother (2009) 1.25
Rising standards for tuberculosis drug development. Trends Pharmacol Sci (2008) 1.25
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis. Infect Immun (2002) 1.24
The crystal structure and catalytic mechanism of cellobiohydrolase CelS, the major enzymatic component of the Clostridium thermocellum Cellulosome. J Mol Biol (2002) 1.23
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet (2006) 1.23
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases. Biochem Biophys Res Commun (2005) 1.22