Published in J Biol Chem on May 19, 2007
Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol (2014) 10.04
TGF-beta-induced epithelial to mesenchymal transition. Cell Res (2009) 7.88
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology (2010) 3.10
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A (2010) 2.32
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology (2009) 2.25
Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells (2008) 2.24
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol (2009) 2.23
TGF-β in progression of liver disease. Cell Tissue Res (2011) 2.22
Epithelial-to-mesenchymal transitions in the liver. Hepatology (2009) 1.99
Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol (2009) 1.85
Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology (2008) 1.82
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology (2008) 1.71
Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma. J Gastroenterol Hepatol (2012) 1.70
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev (2012) 1.68
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem Biol Interact (2011) 1.44
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J Exp Med (2009) 1.39
Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. Clin Exp Metastasis (2011) 1.37
Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS One (2009) 1.33
Hepatocyte-derived Snail1 propagates liver fibrosis progression. Mol Cell Biol (2011) 1.32
Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J Virol (2009) 1.27
Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro. Am J Physiol Lung Cell Mol Physiol (2009) 1.27
Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition. PLoS One (2012) 1.22
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options. Comp Hepatol (2007) 1.22
The epithelial-to-mesenchymal transition in liver fibrosis: here today, gone tomorrow? Hepatology (2010) 1.18
Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC). BMC Cancer (2013) 1.08
Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey. World J Gastroenterol (2009) 1.08
Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge. Front Med (Lausanne) (2015) 1.07
Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine. PLoS One (2013) 1.07
Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium. Infect Immun (2009) 1.03
Cellular sources of extracellular matrix in hepatic fibrosis. Clin Liver Dis (2008) 1.03
Cytokines and STATs in Liver Fibrosis. Front Physiol (2012) 1.02
Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol (2008) 1.02
Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture. Hepatology (2012) 1.02
Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. Biomaterials (2011) 1.01
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium. Mol Vis (2008) 0.99
Evidence for and against epithelial-to-mesenchymal transition in the liver. Am J Physiol Gastrointest Liver Physiol (2013) 0.96
Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J Cell Mol Med (2008) 0.96
Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury. Biomaterials (2010) 0.96
Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth. Am J Pathol (2010) 0.95
Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver. J Biol Chem (2009) 0.91
Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats. Lab Invest (2011) 0.90
The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration. Gut Liver (2016) 0.88
Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int (2014) 0.88
Growth factor- and cytokine-driven pathways governing liver stemness and differentiation. World J Gastroenterol (2010) 0.88
Genetics of breast cancer bone metastasis: a sequential multistep pattern. Clin Exp Metastasis (2014) 0.87
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. Mol Cancer (2014) 0.87
Hepatic regeneration and the epithelial to mesenchymal transition. World J Gastroenterol (2013) 0.86
Fucosylated TGF-β receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells. Br J Cancer (2013) 0.86
Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition. World J Hepatol (2014) 0.85
Dynamic expression of desmin, α-SMA and TGF-β1 during hepatic fibrogenesis induced by selective bile duct ligation in young rats. Braz J Med Biol Res (2014) 0.85
Epithelial-mesenchymal transition in liver fibrosis. Biomed Rep (2016) 0.84
MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway. Mol Med Rep (2015) 0.83
Ebola virus modulates transforming growth factor β signaling and cellular markers of mesenchyme-like transition in hepatocytes. J Virol (2014) 0.83
Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies. Hepat Med (2011) 0.83
Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis. J Clin Med (2016) 0.82
Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells. PLoS One (2012) 0.82
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status. BMC Cancer (2008) 0.82
Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. Gut Liver (2017) 0.81
Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials (2013) 0.81
Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. PLoS One (2012) 0.81
Tetraspanin in oncogenic epithelial-mesenchymal transition. J Clin Invest (2008) 0.80
Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies. Clin Gastroenterol Hepatol (2013) 0.80
Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm. World J Clin Oncol (2012) 0.80
Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-β/Smad signaling in hepatocytes. Lab Invest (2015) 0.80
Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes. Results Immunol (2014) 0.80
Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells. J Transplant (2011) 0.80
Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res (2016) 0.79
Local control of hepatic phenotype with growth factor-encoded surfaces. Integr Biol (Camb) (2014) 0.79
Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large T antigen-immortalized rat liver cell lines. Cell Biol Int Rep (2010) (2010) 0.79
The anti-fibrotic effect of bone morphogenic protein-7(BMP-7) on liver fibrosis. Int J Med Sci (2013) 0.79
RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition of Hepatocytes During Hepatic Fibrosis. J Cell Biochem (2016) 0.78
Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways. Toxins (Basel) (2017) 0.78
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions. J Clin Med (2016) 0.78
MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis. PLoS One (2014) 0.78
New role and molecular mechanism of Gadd45a in hepatic fibrosis. World J Gastroenterol (2016) 0.77
Adverse outcome pathway development from protein alkylation to liver fibrosis. Arch Toxicol (2016) 0.77
Potential roles of BMP9 in liver fibrosis. Int J Mol Sci (2014) 0.77
Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-β1/Smad2/3 signalling. Br J Pharmacol (2014) 0.77
Smad mediated regulation of inhibitor of DNA binding 2 and its role in phenotypic maintenance of human renal proximal tubule epithelial cells. PLoS One (2013) 0.77
Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide. Am J Pathol (2013) 0.75
Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are? World J Gastroenterol (2014) 0.75
Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. Exp Ther Med (2013) 0.75
Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis. J Clin Med (2015) 0.75
Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases. Diagn Pathol (2016) 0.75
Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34+ Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury. Stem Cells Transl Med (2016) 0.75
Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells. Sci Rep (2016) 0.75
The Potential Role of Elk-3/Egr-1 Signaling Pathway in the Epithelial-Mesenchymal Transition during Liver Fibrosis. Gut Liver (2017) 0.75
Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT). Purinergic Signal (2016) 0.75
Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung. Oncol Lett (2010) 0.75
MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. Aging Cell (2017) 0.75
Immunohistochemical study for the origin of ductular reaction in chronic liver disease. Int J Clin Exp Pathol (2014) 0.75
TARGETED INACTIVATION OF COPPER-TRANSPORTER ATP7B IN HEPATOCYTES CAUSES LIVER STEATOSIS AND OBESITY IN MICE. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes. Front Physiol (2017) 0.75
Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis. Front Immunol (2017) 0.75
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A (2005) 3.18
Human bile contains microRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis. Hepatology (2014) 2.98
Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol (2013) 2.50
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet (2003) 2.33
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
Unresectable hepatocellular carcinoma: MR imaging after intraarterial therapy. Part II. Response stratification using volumetric functional criteria after intraarterial therapy. Radiology (2013) 1.66
Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin. J Am Soc Nephrol (2004) 1.55
Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res (2013) 1.45
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology (2004) 1.30
MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint. Hepatology (2011) 1.22
Conditional deletion of c-myc does not impair liver regeneration. Cancer Res (2006) 1.19
Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma. Cell Cycle (2012) 1.08
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. Hepatology (2010) 1.08
Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol (2009) 1.02
Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters. PLoS One (2010) 1.01
p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology (2009) 0.99
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology (2009) 0.99
Dose-dense chemotherapy improves mechanisms of antitumor immune response. Cancer Res (2012) 0.99
Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease. J Immunol (2013) 0.97
Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation. Biochem Biophys Res Commun (2002) 0.96
Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology (2008) 0.96
Unmasking of autoimmune hepatitis in a patient with MS following interferon beta therapy. Neurology (2006) 0.95
1,25-dihydroxyvitamin D3 and its nuclear receptor repress human α1 (I) collagen expression and type I collagen formation. Liver Int (2013) 0.94
Effects of ethanol and acetaldehyde on reactive oxygen species production in rat hepatic stellate cells. Alcohol Clin Exp Res (2006) 0.94
Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter. J Biol Chem (2004) 0.94
Immune mechanism of the antitumor effects generated by bortezomib. J Immunol (2012) 0.93
Symmetric structures in the universe of protein folds. J Chem Inf Model (2009) 0.92
Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch. PLoS One (2012) 0.92
Cadmium exposure and liver disease among US adults. J Gastrointest Surg (2013) 0.92
Gene expression profile of renal proximal tubules regulated by proteinuria. Kidney Int (2002) 0.91
Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol (2003) 0.90
Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice. Biochim Biophys Acta (2006) 0.89
Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress. Autophagy (2013) 0.88
Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration. Biol Trace Elem Res (2009) 0.86
Strategy for eliciting antigen-specific CD8+ T cell-mediated immune response against a cryptic CTL epitope of merkel cell polyomavirus large T antigen. Cell Biosci (2012) 0.86
Targeted coating with antigenic peptide renders tumor cells susceptible to CD8(+) T cell-mediated killing. Mol Ther (2012) 0.85
Endotoxin enhances liver alcohol dehydrogenase by action through upstream stimulatory factor but not by nuclear factor-kappa B. J Biol Chem (2002) 0.83
Activation of the human alpha1(I) collagen promoter by leptin is not mediated by transforming growth factor beta responsive elements. Biochem Biophys Res Commun (2003) 0.83
Regulation of the murine alpha(2)(I) collagen promoter by retinoic acid and retinoid X receptors. Arch Biochem Biophys (2002) 0.83
Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis. Liver Int (2006) 0.82
USIDNET: a strategy to build a community of clinical immunologists. J Clin Immunol (2014) 0.82
Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells. Alcohol Alcohol (2004) 0.82
Effects of vitamin D3 stimulation of thioredoxin-interacting protein in hepatocellular carcinoma. Hepatol Res (2014) 0.81
ARPKD and ADPKD: first cousins or more distant relatives? J Am Soc Nephrol (2008) 0.81
Albumin turns on a vicious spiral of oxidative stress in renal proximal tubules. Kidney Int (2004) 0.80
Oral contraceptive pill use is associated with reduced odds of nonalcoholic fatty liver disease in menstruating women: results from NHANES III. J Gastroenterol (2012) 0.79
Effects of acetaldehyde on hepatocyte glycerol uptake and cell size: implication of aquaporin 9. Alcohol Clin Exp Res (2011) 0.79
Orally active vitamin d for potential chemoprevention of posttransplant malignancy. Cancer Prev Res (Phila) (2012) 0.79
Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoni. Liver (2002) 0.78
Hepatopulmonary Syndrome Is a Frequent Cause of Dyspnea in the Short Telomere Disorders. Chest (2015) 0.78
Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis. Alcohol Clin Exp Res (2007) 0.78
Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors. Arch Biochem Biophys (2004) 0.77
Leptin deficiency prevents the activation of the murine alpaha 2(I) collagen promoter by acetaldehyde. Arch Biochem Biophys (2004) 0.76
Assessing liver fibrosis: comparison of arterial enhancement fraction and diffusion-weighted imaging. J Magn Reson Imaging (2013) 0.76
Chemoembolization decreases drop-off risk of hepatocellular carcinoma patients on the liver transplant list. Cardiovasc Intervent Radiol (2010) 0.76
Quality of life, perceptions of change, and psychological well-being of the elderly population in small rural towns in the Midwest. Int J Aging Hum Dev (2014) 0.75
A single daily dose enhances the adherence to immunosuppressive treatment in kidney transplant recipients: a cross-sectional study. Clin Exp Nephrol (2012) 0.75
Don't look at the eyes: Live interaction reveals strong eye avoidance behavior in autism. J Vis (2015) 0.75
1758: EXCHANGE TRANSFUSION FOR SEVERE PLASMODIUM FALCIPARUM MALARIAL INFECTION. Crit Care Med (2016) 0.75
460: USING PROBIOTICS IN THE CRITICALLY ILL: A META-ANALYSIS OF 2,808 PATIENTS. Crit Care Med (2016) 0.75
Entrustable professional activities for gastroenterology fellowship training. Gastrointest Endosc (2014) 0.75
Proximate mechanisms driving circadian control of neuroendocrine function: Lessons from the young and old. Integr Comp Biol (2009) 0.75