Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 4558529)

Published in Front Med (Lausanne) on September 03, 2015

Authors

Bram Piersma1, Ruud A Bank1, Miriam Boersema1

Author Affiliations

1: Matrix Research Group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen , Groningen , Netherlands.

Articles citing this

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab (2016) 1.39

Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation. Oncotarget (2016) 0.80

Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ. Oncotarget (2016) 0.79

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids Barriers CNS (2016) 0.78

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer. Gastroenterology (2016) 0.77

The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury. Sci Rep (2017) 0.76

Identification of Pathways in Liver Repair Potentially Targeted by Secretory Proteins from Human Mesenchymal Stem Cells. Int J Mol Sci (2016) 0.76

Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res (2016) 0.76

Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-β1 pathway. Sci Rep (2016) 0.75

TAZ activation drives fibroblast spheroid growth, expression of pro-fibrotic paracrine signals, and context dependent ECM gene expression. Am J Physiol Cell Physiol (2016) 0.75

Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling. Oncotarget (2016) 0.75

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination. Nat Commun (2017) 0.75

Biomechanical relationships between the corneal endothelium and Descemet's membrane. Exp Eye Res (2016) 0.75

Curcumin Inhibits Transforming Growth Factor β Induced Differentiation of Mouse Lung Fibroblasts to Myofibroblasts. Front Pharmacol (2016) 0.75

The Treatment of Fibrosis of Joint Synovium and Frozen Shoulder by Smad4 Gene Silencing in Rats. PLoS One (2016) 0.75

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell (2017) 0.75

Putting Cells into Context. Front Cell Dev Biol (2017) 0.75

The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease. Am J Pathol (2016) 0.75

Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation. Oncotarget (2017) 0.75

Recent advances in understanding contextual TGFβ signaling. F1000Res (2017) 0.75

The emerging role of YAP/TAZ in mechanotransduction. J Thorac Dis (2017) 0.75

Articles cited by this

(truncated to the top 100)

Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94

TGF-beta signal transduction. Annu Rev Biochem (1998) 17.83

Wnt/β-catenin signaling and disease. Cell (2012) 16.05

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol (2002) 14.80

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05

beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 12.97

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell (1996) 11.70

Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34

TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88

TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev (2000) 8.24

YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11

Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10

TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08

Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 8.02

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34

Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13

Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest (2004) 5.97

Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol (2008) 5.83

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 5.45

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev (2001) 5.41

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia (1971) 5.14

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55

Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30

Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell (2001) 4.25

Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 4.19

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19

Fibrosis--a common pathway to organ injury and failure. N Engl J Med (2015) 3.94

Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol (2006) 3.42

Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol (2009) 3.42

Latent TGF-β structure and activation. Nature (2011) 3.42

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20

The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 3.16

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation (2007) 3.07

Role of TAZ as mediator of Wnt signaling. Cell (2012) 3.05

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03

The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev (2014) 3.03

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem (1995) 3.01

Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94

Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76

Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75

Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. Eur J Cell Biol (2008) 2.74

Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med (2013) 2.72

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell (2014) 2.70

Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A (2010) 2.66

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun (2012) 2.65

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell (2014) 2.62

Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem (2007) 2.62

Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem (2008) 2.61

Alternative wnt signaling is initiated by distinct receptors. Sci Signal (2008) 2.52

Wnt signaling and the polarity of the primary body axis. Cell (2009) 2.46

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45

Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell (2006) 2.41

Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31

Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol (2005) 2.27

The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27

The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J (2005) 2.15

Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol (2010) 2.01

Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med (2001) 1.98

Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol (2011) 1.97

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94

Phospho-control of TGF-beta superfamily signaling. Cell Res (2009) 1.91

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol (2010) 1.89

A role for Wnt-4 in renal fibrosis. Am J Physiol Renal Physiol (2002) 1.88

Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 1.82

Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. EMBO J (2012) 1.81

Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 1.81

Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission. Eur J Cell Biol (2005) 1.77

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 1.76

Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem (2003) 1.73

Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription. Biochim Biophys Acta (2012) 1.73

Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol Cell Biol (2001) 1.69

Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 1.68

Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2013) 1.67

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell (2005) 1.65

Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol (2011) 1.62

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.61

A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev (2011) 1.60

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis (2013) 1.57

Nucleocytoplasmic shuttling of Smad proteins. Cell Res (2009) 1.55

Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition. Kidney Int (2011) 1.55