Published in Proc Natl Acad Sci U S A on May 17, 2007
High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria. Proc Natl Acad Sci U S A (2008) 1.54
Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia. Haematologica (2011) 1.23
Non-transfusion-dependent thalassemias. Haematologica (2013) 1.21
Hb E/beta-thalassaemia: a common & clinically diverse disorder. Indian J Med Res (2011) 1.00
The hemoglobin E thalassemias. Cold Spring Harb Perspect Med (2012) 0.91
Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon. BMC Infect Dis (2012) 0.89
The pathophysiology of malarial anaemia: where have all the red cells gone? BMC Med (2008) 0.84
Erythropoietin levels are not independently associated with malaria-attributable severe disease in Mozambican children. PLoS One (2011) 0.82
Effects of iron supplementation twice a week on attention score and haematologic measures in female high school students. Singapore Med J (2014) 0.75
Age-related pattern and monocyte-acquired haemozoin associated production of erythropoietin in children with severe malarial anaemia in Ghana. BMC Res Notes (2014) 0.75
Iron overload across the spectrum of non-transfusion-dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions. Br J Haematol (2016) 0.75
When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia. Vox Sang (2014) 0.75
Indicators of life-threatening malaria in African children. N Engl J Med (1995) 13.17
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A (2000) 5.20
Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther (1998) 3.57
Clinical features and pathogenesis of severe malaria. Trends Parasitol (2004) 2.73
Erythropoietin as an antiapoptotic, tissue-protective cytokine. Cell Death Differ (2004) 2.39
alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci U S A (1997) 2.19
Recombinant human erythropoietin prevents the death of mice during cerebral malaria. J Infect Dis (2006) 2.06
Abnormal RNA processing due to the exon mutation of beta E-globin gene. Nature (1982) 1.98
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem (2000) 1.71
Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc (2005) 1.45
Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood (1990) 1.39
Haemoglobin E beta thalassaemia in Sri Lanka. Lancet (2005) 1.23
Hemoglobinopathies in Southeast Asia: molecular biology and clinical medicine. Hemoglobin (1997) 1.20
Increased erythropoietin production in children with severe malarial anemia. Am J Trop Med Hyg (1995) 1.13
Anemia and interleukin-10, tumor necrosis factor alpha, and erythropoietin levels among children with acute, uncomplicated Plasmodium falciparum malaria. Clin Diagn Lab Immunol (2001) 1.10
Serum levels of erythropoietin in acute Plasmodium falciparum malaria. Am J Trop Med Hyg (1996) 1.10
Sickle cell anemia patients have low erythropoietin levels for their degree of anemia. Blood (1986) 0.98
Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. J Appl Physiol (1985) (2000) 0.95
Serum erythropoietin and erythropoiesis in high- and low-fetal hemoglobin beta-thalassemia intermedia patients. Blood (1994) 0.91
Severity differences in beta-thalassaemia/haemoglobin E syndromes: implication of genetic factors. Br J Haematol (1993) 0.90
The molecular basis for the thalassaemias in Sri Lanka. Br J Haematol (2003) 0.90
The endogenous erythropoietin response and the erythropoietic response to blood loss anemia: the effects of age and gender. J Lab Clin Med (1995) 0.89
Erythropoietin response to anemia as a function of age. J Am Geriatr Soc (1991) 0.84
Serum erythropoietin levels in pediatric patients with beta-thalassemia/hemoglobin E. Clin Lab (2002) 0.79
Difference in pattern of erythropoietin response between beta-thalassemia/hemoglobin E children and adults. Southeast Asian J Trop Med Public Health (1997) 0.79
The inhumanity of medicine. BMJ (1995) 13.98
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science (1998) 7.51
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature (1985) 7.34
Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms. Nature (1986) 4.84
Structure of the reaction center from Rhodobacter sphaeroides R-26: the cofactors. Proc Natl Acad Sci U S A (1987) 4.44
Alpha-thalassaemia caused by a polyadenylation signal mutation. Nature (1984) 4.41
Structure of the reaction center from Rhodobacter sphaeroides R-26: the protein subunits. Proc Natl Acad Sci U S A (1987) 3.91
K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin. Nature (1979) 3.75
Crystallographic structure of the nitrogenase iron protein from Azotobacter vinelandii. Science (1992) 3.58
Refined crystal structure of carboxypeptidase A at 1.54 A resolution. J Mol Biol (1983) 3.56
Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer. Science (1997) 3.30
Molecular basis of length polymorphism in the human zeta-globin gene complex. Proc Natl Acad Sci U S A (1983) 3.27
Structure of ADP x AIF4(-)-stabilized nitrogenase complex and its implications for signal transduction. Nature (1997) 3.26
Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol (1992) 3.12
High incidence of malaria in alpha-thalassaemic children. Nature (1996) 3.12
Absence of malaria-specific mortality in children in an area of hyperendemic malaria. Trans R Soc Trop Med Hyg (1998) 3.09
Recent developments in the molecular genetics of human hemoglobin. Cell (1979) 3.09
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet (2003) 3.07
The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion. Nature (1974) 3.04
Heparin structure and interactions with basic fibroblast growth factor. Science (1996) 3.00
A review of the molecular genetics of the human alpha-globin gene cluster. Blood (1989) 2.84
Highly variable regions of DNA flank the human alpha globin genes. Nucleic Acids Res (1981) 2.83
An inward-facing conformation of a putative metal-chelate-type ABC transporter. Science (2006) 2.80
Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster. EMBO J (1986) 2.77
Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet (1997) 2.77
Globin synthesis in thalassaemia: an in vitro study. Nature (1965) 2.74
Structural models for the metal centers in the nitrogenase molybdenum-iron protein. Science (1992) 2.72
A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature (1988) 2.70
Respiratory diseases among U.S. military personnel: countering emerging threats. Emerg Infect Dis (1999) 2.61
Structure of the Escherichia coli fumarate reductase respiratory complex. Science (1999) 2.59
First-trimester fetal diagnosis for haemoglobinopathies: three cases. Lancet (1982) 2.55
DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet (1986) 2.55
Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase. Science (1995) 2.54
The interaction of alpha-thalassemia and homozygous sickle-cell disease. N Engl J Med (1982) 2.52
Embryonic erythroid differentiation in the human leukemic cell line K562. Proc Natl Acad Sci U S A (1981) 2.42
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell (1979) 2.41
IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria. Am J Trop Med Hyg (1998) 2.41
Out-patient Treatment of Early Syphilis with Penicillin. Br Med J (1946) 2.40
Academia and industry: lessons from the unfortunate events in Toronto. Lancet (1999) 2.39
Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. Science (1996) 2.35
Survival and desferrioxamine in thalassaemia major. Br Med J (Clin Res Ed) (1982) 2.35
Hemoglobin H disease and mental retardation: a new syndrome or a remarkable coincidence? N Engl J Med (1981) 2.35
Redox-dependent structural changes in the nitrogenase P-cluster. Biochemistry (1997) 2.34
Rapid detection and prenatal diagnosis of beta-thalassaemia: studies in Indian and Cypriot populations in the UK. Lancet (1990) 2.33
Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature (1978) 2.28
Detection of breakpoints in submicroscopic chromosomal translocation, illustrating an important mechanism for genetic disease. Lancet (1989) 2.28
Three-dimensional structures of acidic and basic fibroblast growth factors. Science (1991) 2.26
Haemoglobin Constant Spring--a chain termination mutant? Nature (1971) 2.25
alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci U S A (1997) 2.19
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction. Proc Natl Acad Sci U S A (1986) 2.16
The spectrum of beta-thalassaemia mutations on the Indian subcontinent: the basis for prenatal diagnosis. Br J Haematol (1991) 2.12
The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu. Trans R Soc Trop Med Hyg (1997) 2.12
Delta-beta-thalassemia is due to a gene deletion. Cell (1976) 2.12
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. Cell (1997) 2.12
X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus. Protein Sci (1992) 2.11
Erythrocytes deficiency in glycophorin resist invasion by the malarial parasite Plasmodium falciparum. Nature (1982) 2.10
Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines. J Immunol (1983) 2.08
Molybdenum-cofactor-containing enzymes: structure and mechanism. Annu Rev Biochem (1997) 2.06
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science (1998) 2.05
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency. Lancet (1983) 2.05
Polycythemia associated with a hemoglobinopathy. J Clin Invest (1966) 1.98
Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia. Br J Haematol (1978) 1.98
A novel alpha-globin gene arrangement in man. Nature (1980) 1.98
The anaemia of P. falciparum malaria. Br J Haematol (1980) 1.97
Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol (2000) 1.95
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Proc Natl Acad Sci U S A (1979) 1.94
Cytosine arabinoside in the treatment of acute myeloblastic leukaemia. Lancet (1971) 1.94
Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16. Br Med J (Clin Res Ed) (1986) 1.93
The importance of anaemia in cerebral and uncomplicated falciparum malaria: role of complications, dyserythropoiesis and iron sequestration. Q J Med (1986) 1.90
Reliable routine estimation of small amounts of foetal haemoglobin by alkali denaturation. J Clin Pathol (1972) 1.88
Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states. Biochemistry (2000) 1.87
Structure of the reaction center from Rhodobacter sphaeroides R-26: protein-cofactor (quinones and Fe2+) interactions. Proc Natl Acad Sci U S A (1988) 1.87
Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: symmetry relations and sequence comparisons between different species. Proc Natl Acad Sci U S A (1988) 1.86
Structure of the reaction center from Rhodobacter sphaeroides R-26: membrane-protein interactions. Proc Natl Acad Sci U S A (1987) 1.84
Thalassaemia in the British. Br Med J (1973) 1.82
Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional. Proc Natl Acad Sci U S A (1980) 1.80
Benign sickle-cell anaemia. Lancet (1972) 1.79
Clinical features and molecular analysis of the alpha thalassemia/mental retardation syndromes. II. Cases without detectable abnormality of the alpha globin complex. Am J Hum Genet (1990) 1.76
Crystallographic structure and functional implications of the nitrogenase molybdenum-iron protein from azotobacter vinelandii. Nature (1992) 1.75
The nitrogenase FeMo-cofactor and P-cluster pair: 2.2 A resolution structures. Science (1993) 1.74
Detection of somatic changes in human cancer DNA by DNA fingerprint analysis. Br J Cancer (1987) 1.74
Structural basis for G.C recognition in the DNA minor groove. Nat Struct Biol (1998) 1.74
Glycophorin as a possible receptor for Plasmodium falciparum. Lancet (1982) 1.69
Fractal surfaces of proteins. Science (1985) 1.69
Experimental evaluation of the effective dielectric constant of proteins. J Mol Biol (1980) 1.68
An improved method for the characterization of human haemoglobin mutants: identification of alpha-2-beta-2-95GLU, haemoglobin N (Baltimore). Nature (1965) 1.68
Iron absorption and loading in beta-thalassaemia intermedia. Lancet (1979) 1.66
Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum. Nature (1977) 1.66
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J (1996) 1.64
Antenatal diagnosis of thalassaemia major. Br Med J (1978) 1.64
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data. J Antimicrob Chemother (2013) 1.61
Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution. J Mol Biol (1982) 1.61
A newly defined X linked mental retardation syndrome associated with alpha thalassaemia. J Med Genet (1991) 1.61
Alpha-thalassemia. Curr Top Hematol (1983) 1.60
The anaemia of Plasmodium falciparum malaria. Br Med Bull (1982) 1.59
Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: protein-cofactor (bacteriochlorophyll, bacteriopheophytin, and carotenoid) interactions. Proc Natl Acad Sci U S A (1988) 1.58
Thalassemia revisited. Cell (1982) 1.58
Mortality and morbidity from malaria after stopping malaria chemoprophylaxis. Trans R Soc Trop Med Hyg (1996) 1.58