Published in Science on September 18, 1992
Mechanism of Mo-dependent nitrogenase. Annu Rev Biochem (2009) 3.00
Mechanism of nitrogen fixation by nitrogenase: the next stage. Chem Rev (2014) 1.83
How many metals does it take to fix N2? A mechanistic overview of biological nitrogen fixation. Proc Natl Acad Sci U S A (2006) 1.83
Catalytic reduction of dinitrogen to ammonia at a single molybdenum center. Acc Chem Res (2005) 1.68
The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter. Proc Natl Acad Sci U S A (2002) 1.59
Maturation of nitrogenase: a biochemical puzzle. J Bacteriol (2005) 1.52
Biological inorganic chemistry at the beginning of the 21st century. Proc Natl Acad Sci U S A (2003) 1.43
Nitrogenase metalloclusters: structures, organization, and synthesis. J Bacteriol (1993) 1.42
X-ray crystal structure of the light-independent protochlorophyllide reductase. Nature (2010) 1.35
A methyldiazene (HN=N-CH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism. Proc Natl Acad Sci U S A (2006) 1.28
Characterizations of diverse residue clusters in protein three-dimensional structures. Proc Natl Acad Sci U S A (1996) 1.21
57Fe ENDOR spectroscopy and 'electron inventory' analysis of the nitrogenase E4 intermediate suggest the metal-ion core of FeMo-cofactor cycles through only one redox couple. J Am Chem Soc (2011) 1.20
Trapping an intermediate of dinitrogen (N2) reduction on nitrogenase. Biochemistry (2009) 1.20
Alkyne substrate interaction within the nitrogenase MoFe protein. J Inorg Biochem (2007) 1.18
Nitrogen fixation in eukaryotes--new models for symbiosis. BMC Evol Biol (2007) 1.16
Catalytic reduction of dinitrogen to ammonia at a single molybdenum center. Proc Natl Acad Sci U S A (2006) 1.08
Synthesis of molybdenum complexes that contain "hybrid" triamidoamine ligands, [(hexaisopropylterphenyl-NCH2CH2)2NCH2CH2N-aryl]3-, and studies relevant to catalytic reduction of dinitrogen. Inorg Chem (2006) 1.07
Overexpression and characterization of an iron storage and DNA-binding Dps protein from Trichodesmium erythraeum. Appl Environ Microbiol (2006) 1.00
Transcriptional profiling of nitrogen fixation in Azotobacter vinelandii. J Bacteriol (2011) 0.99
Variant MoFe proteins of Azotobacter vinelandii: effects of carbon monoxide on electron paramagnetic resonance spectra generated during enzyme turnover. J Biol Inorg Chem (2005) 0.98
Fe-N2/CO complexes that model a possible role for the interstitial C atom of FeMo-cofactor (FeMoco). Proc Natl Acad Sci U S A (2013) 0.97
Characterization of an Fe≡N-NH2 Intermediate Relevant to Catalytic N2 Reduction to NH3. J Am Chem Soc (2015) 0.96
Evidence for a dynamic role for homocitrate during nitrogen fixation: the effect of substitution at the alpha-Lys426 position in MoFe-protein of Azotobacter vinelandii. Biochem J (2006) 0.94
Molybdenum-independent nitrogenases of Azotobacter vinelandii: a functional species of alternative nitrogenase-3 isolated from a molybdenum-tolerant strain contains an iron-molybdenum cofactor. Biochem J (1993) 0.93
Synthesis of [(DPPNCH2CH2)3N]3- molybdenum complexes (DPP = 3,5-(2,5-Diisopropylpyrrolyl)2C6H3) and studies relevant to catalytic reduction of dinitrogen. J Am Chem Soc (2010) 0.92
Synthesis of [(HIPTNCH2CH2)3N]V compounds (HIPT = 3,5-(2,4,6-i-Pr3C6H2)2C6H3) and an evaluation of vanadium for the reduction of dinitrogen to ammonia. Inorg Chem (2006) 0.91
Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor. Elife (2015) 0.89
Alignment of distantly related protein structures: algorithm, bound and implications to homology modeling. Bioinformatics (2011) 0.89
Nitrogen-fixing and uricolytic bacteria associated with the gut of Dendroctonus rhizophagus and Dendroctonus valens (Curculionidae: Scolytinae). Microb Ecol (2013) 0.88
Tracing the interstitial carbide of the nitrogenase cofactor during substrate turnover. J Am Chem Soc (2013) 0.87
Electron transfer precedes ATP hydrolysis during nitrogenase catalysis. Proc Natl Acad Sci U S A (2013) 0.86
Quantitative geometric descriptions of the belt iron atoms of the iron-molybdenum cofactor of nitrogenase and synthetic iron(II) model complexes. Inorg Chem (2007) 0.84
Docking of nitrogenase iron- and molybdenum-iron proteins for electron transfer and MgATP hydrolysis: the role of arginine 140 and lysine 143 of the Azotobacter vinelandii iron protein. Protein Sci (1994) 0.82
The sixteenth iron in the nitrogenase MoFe protein. Angew Chem Int Ed Engl (2013) 0.81
The role of a conserved tyrosine residue in high-potential iron sulfur proteins. Protein Sci (1995) 0.81
A journey into the active center of nitrogenase. J Biol Inorg Chem (2014) 0.81
Structural and biochemical implications of single amino acid substitutions in the nucleotide-dependent switch regions of the nitrogenase Fe protein from Azotobacter vinelandii. J Biol Inorg Chem (2004) 0.81
Nitrogenase FeMoco investigated by spatially resolved anomalous dispersion refinement. Nat Commun (2016) 0.81
Access to Formally Ni(I) States in a Heterobimetallic NiZn System. Chem Sci (2015) 0.80
Structural investigation of the molybdenum site of the periplasmic nitrate reductase from Thiosphaera pantotropha by X-ray absorption spectroscopy. Biochem J (1996) 0.80
Selenol binds to iron in nitrogenase iron-molybdenum cofactor: an extended x-ray absorption fine structure study. Proc Natl Acad Sci U S A (1994) 0.79
Energy transduction by nitrogenase: binding of MgADP to the MoFe protein is dependent on the oxidation state of the iron-sulphur 'P' clusters. Biochem J (1993) 0.79
Production and isolation of vanadium nitrogenase from Azotobacter vinelandii by molybdenum depletion. J Biol Inorg Chem (2016) 0.78
The discovery of Mo(III) in FeMoco: reuniting enzyme and model chemistry. J Biol Inorg Chem (2014) 0.78
Nitrogenase and homologs. J Biol Inorg Chem (2014) 0.78
Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen. Proc Natl Acad Sci U S A (2006) 0.78
Regulation of legume nodulation by acidic growth conditions. Plant Signal Behav (2013) 0.77
Nitrogenase FeMo cofactor: an atomic structure in three simple steps. J Biol Inorg Chem (2014) 0.77
Site-directed mutagenesis of Azotobacter vinelandii ferredoxin I: cysteine ligation of the [4Fe-4S] cluster with protein rearrangement is preferred over serine ligation. Proc Natl Acad Sci U S A (1995) 0.77
Metalloprotein Crystallography: More than a Structure. Acc Chem Res (2016) 0.77
Grand Challenges and Future Opportunities for Metal-Organic Frameworks. ACS Cent Sci (2017) 0.77
Ion binding to biological macromolecules. Asian J Phys (2014) 0.76
Theoretical studies on mechanisms of some Mo enzymes. J Biol Inorg Chem (2015) 0.76
Nitrogenase of Klebsiella pneumoniae: electron nuclear double resonance (ENDOR) studies on the substrate reduction site. Biochem J (1994) 0.75
Electron-paramagnetic-resonance and magnetic-circular-dichroism studies of the binding of cyanide and thiols to the thiols to the iron-molybdenum cofactor from Klebsiella pneumoniae nitrogenase. Biochem J (1994) 0.75
An intimate look at nitrogen's bio-partner. Science (1992) 0.75
Waltzing around cofactors. Elife (2016) 0.75
Insights into hydrocarbon formation by nitrogenase cofactor homologs. MBio (2015) 0.75
Klebsiella pneumoniae nitrogenase MoFe protein: chymotryptic proteolysis affects function by limited cleavage of the beta-chain and provides high-specific-activity MoFe protein. Biochem J (1993) 0.75
Unraveling the interactions of the physiological reductant flavodoxin with the different conformations of the Fe protein in the nitrogenase cycle. J Biol Chem (2017) 0.75
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science (1998) 7.51
Structure of the reaction center from Rhodobacter sphaeroides R-26: the cofactors. Proc Natl Acad Sci U S A (1987) 4.44
Structure of the reaction center from Rhodobacter sphaeroides R-26: the protein subunits. Proc Natl Acad Sci U S A (1987) 3.91
Crystallographic structure of the nitrogenase iron protein from Azotobacter vinelandii. Science (1992) 3.58
Refined crystal structure of carboxypeptidase A at 1.54 A resolution. J Mol Biol (1983) 3.56
Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer. Science (1997) 3.30
Structure of ADP x AIF4(-)-stabilized nitrogenase complex and its implications for signal transduction. Nature (1997) 3.26
Heparin structure and interactions with basic fibroblast growth factor. Science (1996) 3.00
An inward-facing conformation of a putative metal-chelate-type ABC transporter. Science (2006) 2.80
Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet (1997) 2.77
Structure of the Escherichia coli fumarate reductase respiratory complex. Science (1999) 2.59
Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase. Science (1995) 2.54
Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. Science (1996) 2.35
Redox-dependent structural changes in the nitrogenase P-cluster. Biochemistry (1997) 2.34
Three-dimensional structures of acidic and basic fibroblast growth factors. Science (1991) 2.26
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction. Proc Natl Acad Sci U S A (1986) 2.16
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. Cell (1997) 2.12
X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus. Protein Sci (1992) 2.11
Molybdenum-cofactor-containing enzymes: structure and mechanism. Annu Rev Biochem (1997) 2.06
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science (1998) 2.05
Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states. Biochemistry (2000) 1.87
Structure of the reaction center from Rhodobacter sphaeroides R-26: protein-cofactor (quinones and Fe2+) interactions. Proc Natl Acad Sci U S A (1988) 1.87
Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: symmetry relations and sequence comparisons between different species. Proc Natl Acad Sci U S A (1988) 1.86
Structure of the reaction center from Rhodobacter sphaeroides R-26: membrane-protein interactions. Proc Natl Acad Sci U S A (1987) 1.84
Crystallographic structure and functional implications of the nitrogenase molybdenum-iron protein from azotobacter vinelandii. Nature (1992) 1.75
The nitrogenase FeMo-cofactor and P-cluster pair: 2.2 A resolution structures. Science (1993) 1.74
Structural basis for G.C recognition in the DNA minor groove. Nat Struct Biol (1998) 1.74
Fractal surfaces of proteins. Science (1985) 1.69
Experimental evaluation of the effective dielectric constant of proteins. J Mol Biol (1980) 1.68
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J (1996) 1.64
Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution. J Mol Biol (1982) 1.61
Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: protein-cofactor (bacteriochlorophyll, bacteriopheophytin, and carotenoid) interactions. Proc Natl Acad Sci U S A (1988) 1.58
Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet (1998) 1.53
Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency. Blood (2001) 1.52
FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Br J Haematol (2000) 1.50
Structure of a photoactive rhodium complex intercalated into DNA. Nat Struct Biol (2000) 1.47
Nitrogenase: a nucleotide-dependent molecular switch. Annu Rev Biochem (1994) 1.45
Minisatellite mutational processes reduce F(st) estimates. Hum Genet (1999) 1.41
A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila. Biochemistry (2000) 1.40
X-ray crystal structure of the nitrogenase molybdenum-iron protein from Clostridium pasteurianum at 3.0-A resolution. Biochemistry (1993) 1.37
'Feeling the pressure': structural insights into a gated mechanosensitive channel. Curr Opin Struct Biol (1999) 1.35
Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science (1995) 1.34
Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. J Mol Biol (1998) 1.33
Conformational flexibility of B-DNA at 0.74 A resolution: d(CCAGTACTGG)(2). J Mol Biol (2000) 1.30
Crystal structure of the all-ferrous [4Fe-4S]0 form of the nitrogenase iron protein from Azotobacter vinelandii. Biochemistry (2001) 1.30
Nitrogenase and biological nitrogen fixation. Biochemistry (1994) 1.29
Peptide-bond distortions and the curvature of alpha-helices. Biopolymers (1986) 1.29
Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution. Proc Natl Acad Sci U S A (1981) 1.19
Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution. Proc Natl Acad Sci U S A (1980) 1.18
CI-977, a novel and selective agonist for the kappa-opioid receptor. Br J Pharmacol (1990) 1.17
Diversity does make a difference: fibroblast growth factor-heparin interactions. Curr Opin Struct Biol (1998) 1.16
Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue. Proc Natl Acad Sci U S A (1980) 1.13
Binding of ligands to the active site of carboxypeptidase A. Proc Natl Acad Sci U S A (1981) 1.12
Crystal structure of the molybdate binding protein ModA. Nat Struct Biol (1997) 1.11
Forces involved in the assembly and stabilization of membrane proteins. FASEB J (1992) 1.10
Molecular basis for the alpha1-protease inhibitor deficiency. Nature (1975) 1.10
Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum. J Biol Chem (2000) 1.08
Structure of a thioredoxin-like [2Fe-2S] ferredoxin from Aquifex aeolicus. J Mol Biol (2000) 1.08
Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+. Structure (2001) 1.08
A non-electrolyte haemolysis assay for diagnosis and prognosis of sickle cell disease. J Physiol (2013) 1.07
Perspectives on non-heme iron protein chemistry. Adv Protein Chem (1991) 1.07
MgATP-Bound and nucleotide-free structures of a nitrogenase protein complex between the Leu 127 Delta-Fe-protein and the MoFe-protein. Biochemistry (2001) 1.06
The isolation and partial characterization of two novel sphingolipids from Neurospora crassa: di(inositolphosphoryl)ceramide and ((gal)3glu)ceramide. J Biol Chem (1974) 1.06
The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors. J Physiol (2012) 1.05
Structure and stability of membrane proteins. Adv Protein Chem (1995) 1.04
Crystallographic analyses of site-directed mutants of the photosynthetic reaction center from Rhodobacter sphaeroides. Biochemistry (1994) 1.02
Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor. Structure (1993) 1.01
Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine. Proc Natl Acad Sci U S A (1983) 1.00
Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis. J Bacteriol (1995) 1.00
Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A. J Mol Biol (2001) 0.99
Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex. Science (1993) 0.99
Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications. J Mol Biol (1999) 0.98
Crystallization and X-ray structure determination of cytochrome c2 from Rhodobacter sphaeroides in three crystal forms. Acta Crystallogr D Biol Crystallogr (1994) 0.98
Age-related changes in adaptation to severe anemia in childhood in developing countries. Proc Natl Acad Sci U S A (2007) 0.97
Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein. Protein Sci (1992) 0.97
Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J Mol Biol (2000) 0.96
Generation of adenosine triphosphate in cytochrome-deficient mutants of Neurospora. J Biol Chem (1975) 0.96
Heme packing motifs revealed by the crystal structure of the tetra-heme cytochrome c554 from Nitrosomonas europaea. Nat Struct Biol (1998) 0.95
Treatment of thalassaemia major with phenylbutyrate and hydroxyurea. Lancet (1997) 0.94
Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex. Curr Opin Struct Biol (2000) 0.93
Structures of ruthenium-modified Pseudomonas aeruginosa azurin and [Ru(2,2'-bipyridine)2(imidazole)2]SO4 x 10H2O. Acta Crystallogr D Biol Crystallogr (1999) 0.92
Are aberrant BCR--ABL transcripts more common than previously thought? Br J Haematol (2000) 0.92
Electrostatic influence on energetics of electron transfer reactions. Proc Natl Acad Sci U S A (1985) 0.91
A leucine-rich repeat variant with a novel repetitive protein structural motif. Nat Struct Biol (1996) 0.89
Structure of the R65Q mutant of yeast 3-phosphoglycerate kinase complexed with Mg-AMP-PNP and 3-phospho-D-glycerate. Biochemistry (1996) 0.89
Stimulus control and the effects of d-amphetamine in the rat. Psychopharmacology (Berl) (1981) 0.88
Overexpression, purification, and crystallization of the membrane-bound fumarate reductase from Escherichia coli. Protein Expr Purif (2000) 0.88
Cross-linking of nitrogenase components. Structure and activity of the covalent complex. J Biol Chem (1989) 0.88
Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and "mixed" CCK-A/CCK-B antagonists. J Med Chem (1993) 0.88
The roles of stimulus control and reinforcement frequency in modulating the behavioral effects of d-amphetamine in the rat. J Exp Anal Behav (1985) 0.87
Workshop on the qualitative and quantitative comparability of human and animal developmental neurotoxicity: summary and implications. Neurotoxicol Teratol (1990) 0.87
Structure of potato inhibitor complex of carboxypeptidase A at 5.5-A resolution. Proc Natl Acad Sci U S A (1980) 0.87
The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia (2010) 0.87
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. J Med Chem (1988) 0.86
Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives. J Med Chem (1990) 0.85
Pentobarbital-like discriminative stimulus properties of halothane, 1,1,1-trichloroethane, isoamyl nitrite, flurothyl and oxazepam in mice. J Pharmacol Exp Ther (1987) 0.85
Discriminative stimulus properties of toluene in the rat. Neurotoxicol Teratol (1990) 0.84
Behavioral effects of toluene are modulated by stimulus control. Toxicol Appl Pharmacol (1983) 0.84