Published in Am J Physiol Renal Physiol on May 30, 2007
Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal (2013) 1.39
Redox outside the box: linking extracellular redox remodeling with intracellular redox metabolism. J Biol Chem (2011) 1.38
Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol (2008) 1.33
The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer. Antioxid Redox Signal (2014) 1.17
Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr (2014) 1.04
One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders. J Cell Mol Med (2009) 0.99
Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress. Am J Physiol Heart Circ Physiol (2010) 0.94
Sulfur-based redox alterations in long-lived Snell dwarf mice. Mech Ageing Dev (2013) 0.92
Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers. Carcinogenesis (2012) 0.85
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics (2009) 0.79
Effect of vitamin B deprivation during pregnancy and lactation on homocysteine metabolism and related metabolites in brain and plasma of mice offspring. PLoS One (2014) 0.77
Redox biochemistry of hydrogen sulfide. J Biol Chem (2010) 3.64
Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study. Stroke (2004) 2.76
D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: a cohort study. Ann Intern Med (2015) 2.63
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem (2009) 2.49
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem (2009) 2.28
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood (2011) 2.02
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nat Biotechnol (2010) 1.98
Cerebral vascular dysfunction during hypercholesterolemia. Stroke (2007) 1.94
Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity (2003) 1.84
Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension (2008) 1.76
ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood (2011) 1.74
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A (2006) 1.66
A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem (2006) 1.61
Decyanation of vitamin B12 by a trafficking chaperone. Proc Natl Acad Sci U S A (2008) 1.60
The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues. Antioxid Redox Signal (2011) 1.60
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke (2004) 1.57
Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome. Mol Cell Proteomics (2008) 1.55
Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun (2011) 1.51
The homocysteine paradox. Arterioscler Thromb Vasc Biol (2008) 1.50
Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation (2004) 1.48
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol (2004) 1.47
Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme. Biochemistry (2002) 1.46
Extracellular redox modulation by regulatory T cells. Nat Chem Biol (2009) 1.45
High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations. Antioxid Redox Signal (2012) 1.44
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product. Mol Genet Metab (2009) 1.40
Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal (2013) 1.39
Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol (2004) 1.39
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 1.37
Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol (2002) 1.36
Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol (2008) 1.33
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci U S A (2004) 1.32
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. Blood (2009) 1.32
ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice. Blood (2012) 1.31
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc Natl Acad Sci U S A (2010) 1.30
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase. Biochemistry (2002) 1.29
PLP-dependent H(2)S biogenesis. Biochim Biophys Acta (2011) 1.29
Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr (2008) 1.29
Spectroscopic evidence for the formation of a four-coordinate Co2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase. J Am Chem Soc (2005) 1.29
A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J Biol Chem (2009) 1.27
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin. J Biol Chem (2013) 1.27
Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood (2007) 1.26
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism. J Biol Chem (2012) 1.26
Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry (2002) 1.24
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nat Protoc (2011) 1.24
Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype. J Immunol (2008) 1.22
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation. J Inorg Biochem (2009) 1.22
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci (2007) 1.22
Adenosyltransferase tailors and delivers coenzyme B12. Nat Chem Biol (2008) 1.21
Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood (2006) 1.20
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res (2002) 1.20
Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J Biol Chem (2007) 1.19
A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria. Proc Natl Acad Sci U S A (2009) 1.19
Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. J Neuropathol Exp Neurol (2003) 1.18
Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase. J Biol Chem (2006) 1.18
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem (2007) 1.18
Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease. J Neurochem (2007) 1.15
Nitrated alpha-synuclein and microglial neuroregulatory activities. J Neuroimmune Pharmacol (2008) 1.15
Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. J Biol Chem (2004) 1.15
Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A (2011) 1.14
Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Nat Prod Rep (2007) 1.14
Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci (2003) 1.13
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone. Biochemistry (2006) 1.13
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. J Biol Chem (2013) 1.13
Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base. Arch Biochem Biophys (2004) 1.11
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol (2002) 1.11
Homocysteine and redox signaling. Antioxid Redox Signal (2005) 1.10
Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol (2006) 1.10
Time line of redox events in aging postmitotic cells. Elife (2013) 1.10
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem (2012) 1.10
Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem (2005) 1.09
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Differential dependence on cysteine from transsulfuration versus transport during T cell activation. Antioxid Redox Signal (2010) 1.09
Redox remodeling as an immunoregulatory strategy. Biochemistry (2010) 1.08
Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology (2010) 1.08
Structural basis of multifunctionality in a vitamin B12-processing enzyme. J Biol Chem (2011) 1.08
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke (2007) 1.07
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Mol Genet Metab (2006) 1.06
Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase. Biochemistry (2004) 1.06
Mirror "base-off" conformation of coenzyme B12 in human adenosyltransferase and its downstream target, methylmalonyl-CoA mutase. J Am Chem Soc (2005) 1.06
Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation. Sci Signal (2013) 1.06
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase. Proc Natl Acad Sci U S A (2007) 1.05
Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry (2005) 1.05
Dynamics of carbon monoxide binding to cystathionine beta-synthase. J Biol Chem (2006) 1.05
A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products. Mol Cell Proteomics (2010) 1.05
Human cystathionine beta-synthase is a target for sumoylation. Biochemistry (2006) 1.05
ADMA and hyperhomocysteinemia. Vasc Med (2005) 1.04
Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr (2014) 1.04
Role of FcRgamma and factor XIIIA in coated platelet formation. Blood (2005) 1.02
A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer. Biochemistry (2007) 1.02
Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J Biol Chem (2009) 1.02
Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. BMC Med Genet (2007) 1.01