Processing of proteins by the molecular chaperone Hsp104.

Chaperones in control of protein disaggregation. EMBO J (2008) 2.01

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A (2010) 1.49

The M-domain controls Hsp104 protein remodeling activity in an Hsp70/Hsp40-dependent manner. J Mol Biol (2010) 1.36

Peptide and protein binding in the axial channel of Hsp104. Insights into the mechanism of protein unfolding. J Biol Chem (2008) 1.34

Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33

Applying Hsp104 to protein-misfolding disorders. Biochem Cell Biol (2010) 1.18

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A (2013) 1.10

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins. Mol Cell Biol (2009) 1.10

The elusive middle domain of Hsp104 and ClpB: location and function. Biochim Biophys Acta (2011) 1.09

Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104). J Biol Chem (2011) 1.08

Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF). Biochim Biophys Acta (2011) 1.08

Regulatory circuits of the AAA+ disaggregase Hsp104. J Biol Chem (2011) 0.97

The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. PLoS One (2009) 0.94

Both ATPase domains of ClpA are critical for processing of stable protein structures. J Biol Chem (2009) 0.92

Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance. EMBO J (2014) 0.91

Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast. Mol Biol Cell (2015) 0.91

Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation. J Cell Biol (2012) 0.91

Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machine. J Struct Biol (2012) 0.87

Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast. Mol Biol Cell (2011) 0.84

Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation. Elife (2016) 0.79

Mechanistic Insights into Hsp104 Potentiation. J Biol Chem (2016) 0.78

Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. Biomed Res Int (2015) 0.78

Suramin inhibits Hsp104 ATPase and disaggregase activity. PLoS One (2014) 0.78

Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variants. Prion (2013) 0.77

Human TorsinA can function in the yeast cytosol as a molecular chaperone. Biochem J (2017) 0.75

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature (2011) 2.31

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90

Protein-modified nanocrystalline diamond thin films for biosensor applications. Nat Mater (2004) 1.76

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65

Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104. J Biol Chem (2005) 1.59

Instrumental variable estimation in a survival context. Epidemiology (2015) 1.56

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104. J Biol Chem (2003) 1.52

The molecular chaperone Hsp104--a molecular machine for protein disaggregation. J Struct Biol (2006) 1.41

Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides. J Biol Chem (2005) 1.32

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle. J Mol Biol (2004) 1.31

Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain. Mol Cell (2008) 1.26

Folding mechanism of the CH2 antibody domain. J Mol Biol (2004) 1.25

The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. Int J Epidemiol (2012) 1.16

The activation mechanism of Hsp26 does not require dissociation of the oligomer. J Mol Biol (2005) 1.05

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest (2013) 1.04

Yeast prion-protein, sup35, fibril formation proceeds by addition and substraction of oligomers. Chembiochem (2006) 1.02

Commentary: building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables. Int J Epidemiol (2013) 1.01

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol (2006) 0.96

Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils. J Mol Biol (2008) 0.96

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angew Chem Int Ed Engl (2011) 0.95

Importance of low-oligomeric-weight species for prion propagation in the yeast prion system Sup35/Hsp104. Proc Natl Acad Sci U S A (2003) 0.92

Extracellular HIV-1 Nef increases migration of monocytes. Exp Cell Res (2006) 0.88

The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proc Natl Acad Sci U S A (2008) 0.88

Characterization and localization of prodiginines from Streptomyces lividans suppressing Verticillium dahliae in the absence or presence of Arabidopsis thaliana. Environ Microbiol (2011) 0.86

Epidemiology of leishmaniasis in Spain based on hospitalization records (1997-2008). Am J Trop Med Hyg (2011) 0.86

Extracellular Streptomyces vesicles: amphorae for survival and defence. Microb Biotechnol (2011) 0.86

Yersinia enterocolitica type III secretion chaperone SycD: recombinant expression, purification and characterization of a homodimer. Protein Expr Purif (2006) 0.85

Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts. Psychoneuroendocrinology (2013) 0.83

Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. J Biol Chem (2009) 0.83

Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information. Am J Epidemiol (2015) 0.82

Is positive affect associated with survival? A population-based study of elderly persons. Am J Epidemiol (2011) 0.80

Application of gadolinium-based contrast agents and prevalence of nephrogenic systemic fibrosis in a cohort of end-stage renal disease patients on hemodialysis. Nephron Clin Pract (2012) 0.80

Characterization of oligomeric species in the fibrillization pathway of the yeast prion Ure2p. Biol Chem (2005) 0.80

Comparing Alternative Effect Decomposition Methods: The Role of Literacy in Mediating Educational Effects on Mortality. Epidemiology (2016) 0.79

Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association. Biochem J (2005) 0.78

A selective assay to detect chitin and biologically active nano-machineries for chitin-biosynthesis with their intrinsic chitin-synthase molecules. Int J Mol Sci (2010) 0.78

Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up. Alzheimer Dis Assoc Disord (2016) 0.77

Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol (2017) 0.77

Accuracy of 3-d needle navigation in interstitial brachytherapy in various body regions. Strahlenther Onkol (2002) 0.76

Switch peptide via Staudinger reaction. Org Lett (2008) 0.76

Edema, Hyperpigmentation, Induration: 3 Skin Signs Heralding Danger in Patients on Maintenance Hemodialysis. Medicine (Baltimore) (2016) 0.75

Changes in memory before and after stroke differ by age and sex, but not by race. Cerebrovasc Dis (2014) 0.75

Unconditional cash transfers for assistance in humanitarian disasters: effect on use of health services and health outcomes in low- and middle-income countries. Cochrane Database Syst Rev (2015) 0.75