Published in Dev Cell on June 01, 2007
The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol (2010) 3.19
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu Rev Cell Dev Biol (2010) 3.04
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Cell (2012) 2.79
Genetics of mammalian meiosis: regulation, dynamics and impact on fertility. Nat Rev Genet (2010) 2.58
Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science (2011) 2.43
Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis. Cell (2009) 2.33
Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell (2012) 2.18
Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J Cell Biol (2009) 2.16
Optimized flow cytometry isolation of murine spermatocytes. Cytometry A (2014) 2.14
Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes Dev (2009) 2.13
A nuclear-envelope bridge positions nuclei and moves chromosomes. J Cell Sci (2009) 2.10
SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A (2009) 2.07
The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nat Rev Mol Cell Biol (2011) 2.01
Meiotic recombination in mammals: localization and regulation. Nat Rev Genet (2013) 2.00
The nuclear envelope in genome organization, expression and stability. Nat Rev Mol Cell Biol (2010) 1.97
Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Dev Cell (2013) 1.96
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem (2009) 1.79
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci (2009) 1.74
Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei. J Cell Biol (2010) 1.70
Lamin-binding Proteins. Cold Spring Harb Perspect Biol (2010) 1.69
Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. J Cell Biol (2007) 1.67
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet (2010) 1.59
Prelude to a division. Annu Rev Cell Dev Biol (2008) 1.55
Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. PLoS One (2015) 1.54
Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol (2008) 1.46
Another way to move chromosomes. Chromosoma (2007) 1.40
Drosophila telomeres: an exception providing new insights. Bioessays (2008) 1.39
The nuclear envelope at a glance. J Cell Sci (2010) 1.38
LINC complexes in health and disease. Nucleus (2011) 1.37
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J Cell Biol (2009) 1.36
Accessorizing and anchoring the LINC complex for multifunctionality. J Cell Biol (2015) 1.35
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol (2012) 1.30
Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development (2009) 1.30
53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell (2015) 1.29
Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections? Trends Cell Biol (2009) 1.28
Mammalian sperm head formation involves different polarization of two novel LINC complexes. PLoS One (2010) 1.27
The LINC-less granulocyte nucleus. Eur J Cell Biol (2008) 1.26
The LINC complex is essential for hearing. J Clin Invest (2013) 1.22
Cohesin SMC1beta protects telomeres in meiocytes. J Cell Biol (2009) 1.22
Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. J Biol Chem (2011) 1.22
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev (2014) 1.20
Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng (2012) 1.19
Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation. J Cell Biol (2009) 1.16
POM121 and Sun1 play a role in early steps of interphase NPC assembly. J Cell Biol (2011) 1.15
K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts. J Nutr Biochem (2009) 1.15
Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants. BMC Plant Biol (2010) 1.13
A role for the nucleoporin Nup170p in chromatin structure and gene silencing. Cell (2013) 1.12
The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin. Chromosoma (2013) 1.11
A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. J Cell Biol (2013) 1.10
Structural insights into LINC complexes. Curr Opin Struct Biol (2013) 1.07
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol (2012) 1.05
Matefin/SUN-1 phosphorylation is part of a surveillance mechanism to coordinate chromosome synapsis and recombination with meiotic progression and chromosome movement. PLoS Genet (2013) 1.02
LINCing complex functions at the nuclear envelope: what the molecular architecture of the LINC complex can reveal about its function. Nucleus (2013) 1.01
KASHing up with the nucleus: novel functional roles of KASH proteins at the cytoplasmic surface of the nucleus. Curr Opin Cell Biol (2014) 1.00
KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression. J Cell Sci (2009) 0.99
Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. J Cell Biol (2015) 0.99
Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep (2012) 0.98
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma (2010) 0.94
The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. J Cell Sci (2010) 0.93
The dissection of meiotic chromosome movement in mice using an in vivo electroporation technique. PLoS Genet (2014) 0.93
Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis. PLoS Genet (2010) 0.93
A dynamic meiotic SUN belt includes the zygotene-stage telomere bouquet and is disrupted in chromosome segregation mutants of maize (Zea mays L.). Front Plant Sci (2014) 0.91
The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. PLoS Genet (2013) 0.91
The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component. BMC Cell Biol (2011) 0.90
Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol (2010) 0.90
Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet (2014) 0.90
Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis. Nucleus (2013) 0.89
Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. PLoS Genet (2014) 0.89
Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity. Nucleus (2010) 0.88
Making the LINC: SUN and KASH protein interactions. Biol Chem (2015) 0.88
The nuclear envelopathies and human diseases. J Biomed Sci (2009) 0.87
Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development. Genes Dev (2014) 0.86
The telomere bouquet regulates meiotic centromere assembly. Nat Cell Biol (2015) 0.85
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope. Nat Commun (2016) 0.85
Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Curr Opin Cell Biol (2012) 0.85
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Temporal and tissue-specific disruption of LINC complexes in vivo. Genesis (2014) 0.84
The meiosis-specific modification of mammalian telomeres. Cell Cycle (2014) 0.84
The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility. Biol Open (2015) 0.84
Sun1 deficiency leads to cerebellar ataxia in mice. Dis Model Mech (2015) 0.83
Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis. Mol Biol Cell (2013) 0.83
Subcellular localization of SUN2 is regulated by lamin A and Rab5. PLoS One (2011) 0.83
Reversal of laminopathies: the curious case of SUN1. Nucleus (2012) 0.83
Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. G3 (Bethesda) (2012) 0.83
The nuclear envelope in the plant cell cycle: structure, function and regulation. Ann Bot (2011) 0.82
Chromosome mechanics and meiotic engine maintenance. PLoS Genet (2008) 0.82
Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. Nucleus (2014) 0.82
CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope. Mol Biol Cell (2009) 0.82
Oocyte Polarization Is Coupled to the Chromosomal Bouquet, a Conserved Polarized Nuclear Configuration in Meiosis. PLoS Biol (2016) 0.82
Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development. Genes Dev (2016) 0.82
Ku70 and non-homologous end joining protect testicular cells from DNA damage. J Cell Sci (2013) 0.81
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. J Cell Biol (2016) 0.80
Finding the correct partner: the meiotic courtship. Scientifica (Cairo) (2012) 0.80
SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells. PLoS One (2015) 0.79
Functional organization and dynamics of the cell nucleus. Front Plant Sci (2014) 0.79
Laminopathies: too much SUN is a bad thing. Curr Biol (2012) 0.79
Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli. Nucleus (2016) 0.78
The kinesin AtPSS1 promotes synapsis and is required for proper crossover distribution in meiosis. PLoS Genet (2014) 0.78
Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements. Nucleus (2015) 0.78
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell (2007) 4.22
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell (2005) 3.97
mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods (2008) 3.88
Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science (2002) 3.38
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell (2008) 3.12
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol (2006) 2.63
ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci (2003) 2.35
A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity (2004) 2.30
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development (2007) 2.27
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A (2009) 2.07
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell (2011) 2.07
GW182 family proteins are crucial for microRNA-mediated gene silencing. Trends Cell Biol (2007) 2.06
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell (2002) 1.98
Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci U S A (2007) 1.97
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell (2009) 1.95
Syne proteins anchor muscle nuclei at the neuromuscular junction. Proc Natl Acad Sci U S A (2005) 1.90
Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nat Cell Biol (2012) 1.89
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol (2004) 1.86
An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech (2008) 1.84
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science (2009) 1.83
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol (2010) 1.77
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Virulence (2010) 1.70
Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell (2007) 1.68
Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity (2007) 1.68
Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol (2004) 1.62
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell (2006) 1.61
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev (2002) 1.60
Nontuberculous mycobacteria: susceptibility pattern and prevalence rate in Shanghai from 2005 to 2008. Chin Med J (Engl) (2010) 1.60
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet (2010) 1.59
An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. J Immunol (2002) 1.52
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity (2003) 1.50
Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. J Immunol (2009) 1.49
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet (2006) 1.47
Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera. PLoS One (2011) 1.46
Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem (2001) 1.46
Diagnostic accuracy of quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions. Int J Cardiol (2012) 1.42
A large-scale functional approach to uncover human genes and pathways in Drosophila. Cell Res (2008) 1.42
Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol (2010) 1.42
Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell (2011) 1.41
Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet (2010) 1.40
LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene (2002) 1.38
ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol (2008) 1.38
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J Immunol (2007) 1.36
A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol (2009) 1.35
Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett (2010) 1.33
Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect (2010) 1.33
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol (2012) 1.30
Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell (2002) 1.29
Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J (2006) 1.29
Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Hum Mol Genet (2012) 1.28
E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity (2012) 1.25
B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice. Immunology (2007) 1.22
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells. Angew Chem Int Ed Engl (2013) 1.21
Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PLoS One (2013) 1.20
lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development (2003) 1.19
E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol Cell Biol (2006) 1.19
microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc Natl Acad Sci U S A (2011) 1.19
Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt. J Am Soc Nephrol (2008) 1.18
A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans. Genes Dev (2008) 1.18
Effect of embedded silica nanospheres on improving the performance of InGaN/GaN light-emitting diodes. Opt Express (2011) 1.16
High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater (2013) 1.16
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity (2013) 1.15
Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J (2003) 1.15
Roles of chromatin factors in C. elegans development. WormBook (2007) 1.14
Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development (2009) 1.14
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc Natl Acad Sci U S A (2002) 1.13
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol (2002) 1.12
New insights into E-protein function in lymphocyte development. Trends Immunol (2005) 1.11
Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK. FEBS Lett (2012) 1.10