Published in Dev Cell on September 01, 2007
NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol (2011) 1.45
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol (2013) 1.21
Ubiquitin in NF-kappaB signaling. Chem Rev (2009) 1.20
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway. Elife (2013) 1.11
Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat (2009) 1.09
Systematic analysis of the physiological importance of deubiquitinating enzymes. PLoS One (2012) 1.08
Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila. PLoS Genet (2014) 1.05
NOPO modulates Egr-induced JNK-independent cell death in Drosophila. Cell Res (2011) 1.02
Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells. J Cell Mol Med (2013) 1.00
A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Mol Cell Proteomics (2010) 0.99
The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth. Nature (2015) 0.96
Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Differ (2013) 0.96
Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. Neuron (2011) 0.94
CYLD: a DUB with many talents. Dev Cell (2007) 0.92
Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A (2011) 0.92
Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mol Cell Biol (2011) 0.90
Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Dis (2013) 0.88
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila. Nat Commun (2012) 0.88
Mechanisms of apoptosis in Crustacea: What conditions induce versus suppress cell death? Apoptosis (2010) 0.87
Identification of a large rearrangement in CYLD as a cause of familial cylindromatosis. Fam Cancer (2011) 0.87
Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. PLoS One (2011) 0.86
The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling. PLoS One (2012) 0.83
Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci U S A (2015) 0.79
The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. Cell Death Dis (2015) 0.79
Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila. Oncogene (2015) 0.79
Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila. Open Biol (2015) 0.78
Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate. Proc Natl Acad Sci U S A (2014) 0.78
Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis. Curr Top Dev Biol (2015) 0.78
Serum response factor controls CYLD expression via MAPK signaling pathway. PLoS One (2011) 0.78
Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Dis (2015) 0.78
Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38. Elife (2016) 0.76
Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A (2017) 0.76
CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes. World J Gastroenterol (2014) 0.75
Eiger-induced cell death relies on Rac1-dependent endocytosis. Cell Death Dis (2016) 0.75
Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development. PLoS Genet (2017) 0.75
Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. Biomed Res Int (2015) 0.75
GLYAT regulates JNK-mediated cell death in Drosophila. Sci Rep (2017) 0.75
Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene (2017) 0.75
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med (2003) 4.08
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J (2002) 3.16
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell (2007) 3.09
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol (2006) 2.63
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development (2007) 2.27
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron (2002) 2.15
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell (2006) 2.15
SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A (2009) 2.07
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell (2011) 2.07
Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol (2007) 2.05
Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell (2009) 2.03
Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci U S A (2007) 1.97
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. J Cell Biol (2003) 1.95
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature (2012) 1.95
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell (2009) 1.95
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol (2004) 1.86
An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech (2008) 1.84
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science (2009) 1.83
p38 MAPK-dependent phagocytic encapsulation confers infection tolerance in Drosophila. Cell Host Microbe (2009) 1.77
DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol (2006) 1.75
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet (2010) 1.59
IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol (2006) 1.57
Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem (2001) 1.46
Diagnostic accuracy of quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions. Int J Cardiol (2012) 1.42
A large-scale functional approach to uncover human genes and pathways in Drosophila. Cell Res (2008) 1.42
Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell (2011) 1.41
LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene (2002) 1.38
ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol (2008) 1.38
A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol (2009) 1.35
Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure. J Cell Biol (2011) 1.34
Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem (2002) 1.34
Involvement of ER stress in retinal cell death. Mol Vis (2007) 1.32
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol (2002) 1.31
ER stress is involved in T17M rhodopsin-induced retinal degeneration. Invest Ophthalmol Vis Sci (2012) 1.31
Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell (2002) 1.29
Regulatory roles of JNK in programmed cell death. J Biochem (2004) 1.28
Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol (2007) 1.20
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity (2013) 1.15
Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J (2005) 1.14
Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo. Proc Natl Acad Sci U S A (2007) 1.11
The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Dev Biol (2005) 1.10
Ecosystem development and carbon cycle on a glacier foreland in the high Arctic, Ny-Alesund, Svalbard. J Plant Res (2005) 1.09
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila. Neurosci Lett (2003) 1.08
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc Natl Acad Sci U S A (2010) 1.08
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila. EMBO J (2005) 1.08
Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci (2004) 1.07
Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res (2002) 1.07
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res (2007) 1.07
A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism. Proc Natl Acad Sci U S A (2008) 1.06
The expanding role of mouse genetics for understanding human biology and disease. Dis Model Mech (2008) 1.05
Modeling Sjögren's syndrome with Id3 conditional knockout mice. Immunol Lett (2011) 1.05
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol (2012) 1.05
Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC. J Biol Chem (2002) 1.04
Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. Proc Natl Acad Sci U S A (2013) 1.04
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J (2003) 1.04
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J Cell Biol (2007) 1.04
Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. J Biol Chem (2004) 1.03
Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Oncogene (2004) 1.03
Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci Res (2003) 1.03
Coiled versus straight peritoneal dialysis catheters: a randomized controlled trial and meta-analysis. Am J Kidney Dis (2011) 1.02
Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J Cell Biol (2009) 1.01
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem (2005) 1.01
Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development (2011) 1.00
Apoptosis ensures spacing pattern formation of Drosophila sensory organs. Curr Biol (2011) 1.00
Simultaneous expression of different transgenes in neurons and glia by combining in utero electroporation with the Tol2 transposon-mediated gene transfer system. Genes Cells (2010) 0.99
Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. EMBO Rep (2012) 0.98
Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem Biophys Res Commun (2007) 0.97
Caspase-mediated changes in Sir2alpha during apoptosis. FEBS Lett (2006) 0.97
Nonautonomous apoptosis is triggered by local cell cycle progression during epithelial replacement in Drosophila. Mol Cell Biol (2011) 0.96
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila. J Biol Chem (2014) 0.96
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum Mol Genet (2004) 0.95
LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization. Cell Res (2011) 0.95
A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene (2003) 0.95
piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS One (2011) 0.95