Published in Am J Respir Crit Care Med on June 15, 2007
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49
Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.57
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J (2010) 1.54
Cardiovascular injury and repair in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2008) 1.11
Association of lung function with physical, mental and cognitive function in early old age. Age (Dordr) (2010) 0.97
Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease. J Biol Chem (2015) 0.85
Co-morbid disease in COPD--more than a coincidence. Int J Chron Obstruct Pulmon Dis (2007) 0.77
17β-estradiol replacement reverses age-related lung disease in estrogen-deficient C57BL/6J mice. Endocrinology (2013) 0.76
SEGEL: A Web Server for Visualization of Smoking Effects on Human Lung Gene Expression. PLoS One (2015) 0.75
Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 3.34
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
Impact of salmeterol/fluticasone propionate versus salmeterol on exacerbations in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 4.82
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest (2003) 3.19
FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts. Eur Respir J (2013) 2.87
Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study. Chest (2006) 1.84
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res (2011) 1.65
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
beta-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun (2002) 1.57
Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol Lung Cell Mol Physiol (2005) 1.57
Antimicrobial peptides: current status and therapeutic potential. Drugs (2003) 1.55
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol (2007) 1.53
Superior vena cava syndrome in thoracic malignancies. Respir Care (2011) 1.52
Comparison of two devices and two breathing patterns for exhaled breath condensate sampling. PLoS One (2011) 1.45
Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med (2002) 1.38
The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells. Lung Cancer (2007) 1.36
TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer. Dis Markers (2005) 1.32
Allergic airway inflammation inhibits pulmonary antibacterial host defense. J Immunol (2006) 1.31
Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations. Respir Res (2010) 1.31
The discovery of α1-antitrypsin and its role in health and disease. Respir Med (2011) 1.30
Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis. J Cyst Fibros (2004) 1.29
Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival. PLoS One (2008) 1.22
Peripheral arterial tonometry, oximetry and actigraphy for ambulatory recording of sleep apnea. Physiol Meas (2004) 1.22
Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ (2012) 1.20
Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis. J Leukoc Biol (2007) 1.18
Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol (2004) 1.18
The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int Immunol (2006) 1.13
The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils. Eur J Immunol (2010) 1.12
The antimicrobial peptide cathelicidin interacts with airway mucus. Peptides (2006) 1.12
Seasonal distribution of COPD exacerbations in the Prevention of Exacerbations with Tiotropium in COPD trial. Chest (2013) 1.09
MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia. Cell Cycle (2010) 1.07
Onset of effect of aclidinium, a novel, long-acting muscarinic antagonist, in patients with COPD. COPD (2010) 1.06
Differential sensitivity of differentiated epithelial cells to respiratory viruses reveals different viral strategies of host infection. J Virol (2008) 1.06
Guideline-based survey of outpatient COPD management by pulmonary specialists in Germany. Int J Chron Obstruct Pulmon Dis (2012) 1.04
Antimicrobial peptides in lung inflammation. Chem Immunol Allergy (2005) 1.04
Functions of antimicrobial peptides in host defense and immunity. Curr Protein Pept Sci (2005) 1.04
FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells. J Immunol (2013) 1.03
Dynamics of heart rate and sleep stages in normals and patients with sleep apnea. Neuropsychopharmacology (2003) 1.02
Exposure of differentiated airway epithelial cells to volatile smoke in vitro. Respiration (2004) 1.00
Nonrandom variability of respiration during sleep in healthy humans. Sleep (2005) 1.00
Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing. PLoS One (2013) 1.00
The cardiopulmonary continuum systemic inflammation as 'common soil' of heart and lung disease. Int J Cardiol (2010) 0.97
The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther (2007) 0.95
Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients. Respir Res (2009) 0.94
Whole-body vibration therapy in intensive care patients: A feasibility and safety study. J Rehabil Med (2016) 0.94
Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program. Respir Med (2007) 0.93
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices. J Biol Chem (2002) 0.92
Indacaterol improves lung hyperinflation and physical activity in patients with moderate chronic obstructive pulmonary disease--a randomized, multicenter, double-blind, placebo-controlled study. BMC Pulm Med (2014) 0.91
Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study. Respir Res (2009) 0.91
Series introduction: Innate host defense of the respiratory epithelium. J Leukoc Biol (2003) 0.89
Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study. BMC Infect Dis (2012) 0.89
Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients. Respir Med (2011) 0.88
Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers. Respiration (2009) 0.88
IL-17C is a mediator of respiratory epithelial innate immune response. Am J Respir Cell Mol Biol (2013) 0.87
Inhibition of NF-kappaB mediated inflammation by siRNA expressed by recombinant adeno-associated virus. J Virol Methods (2004) 0.86
Efficacy of indacaterol in the treatment of patients with COPD. Prim Care Respir J (2011) 0.86
Application of small interfering RNA (siRNA) for modulation of airway epithelial gene expression. Oligonucleotides (2005) 0.85
Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose. Respirology (2011) 0.85
Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastrointestinal tracts. Cell Tissue Res (2006) 0.85
The blood-borne miRNA signature of lung cancer patients is independent of histology but influenced by metastases. Mol Cancer (2014) 0.85
Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach. Orphanet J Rare Dis (2013) 0.85
Alpha1-antitrypsin deficiency - diagnostic testing and disease awareness in Germany and Italy. Respir Med (2013) 0.85
The human host defense peptide LL37/hCAP accelerates angiogenesis in PEGT/PBT biopolymers. Ann Plast Surg (2006) 0.84
Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations. Int J Chron Obstruct Pulmon Dis (2009) 0.84
Ambient temperature impacts on pH of exhaled breath condensate. Respirology (2009) 0.84
Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial. BMC Pulm Med (2014) 0.83
Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respir Res (2014) 0.83
NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37. Stem Cells (2010) 0.83
c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur J Immunol (2011) 0.83
Imatinib-associated pulmonary alveolar proteinosis. Am J Med (2003) 0.82
Impact of different definitions of airflow limitation on the prevalence of chronic obstructive pulmonary disease in the general population. Respiration (2010) 0.82
Effects of the antimicrobial peptide LL-37 and hyperthermic preconditioning in septic rats. Anesthesiology (2007) 0.82
Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy. Stem Cells Transl Med (2013) 0.82
Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD. Respirology (2011) 0.81
Cell-specific modulation of surfactant proteins by ambroxol treatment. Toxicol Appl Pharmacol (2005) 0.81
The EvA study: aims and strategy. Eur Respir J (2012) 0.81
Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency. Orphanet J Rare Dis (2012) 0.80
Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe. Respir Med (2012) 0.80
Interaction of allergic airway inflammation and innate immunity: hygiene and beyond. J Occup Med Toxicol (2008) 0.80
Tracheostomy and related host-pathogen interaction are associated with airway inflammation as characterized by tracheal aspirate analysis. Respir Med (2008) 0.79
Allergic airway inflammation induces the migration of dendritic cells into airway sensory ganglia. Respir Res (2014) 0.79
CDA-2, a urinary preparation, inhibits lung cancer development through the suppression of NF-kappaB activation in myeloid cell. PLoS One (2012) 0.79
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS. FASEB J (2010) 0.79