Published in FASEB J on April 12, 2010
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol Vis Sci (2014) 1.52
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res (2010) 1.38
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol (2011) 1.35
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal (2012) 1.03
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J (2013) 1.02
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01
The role of sirtuins in modulating redox stressors. Free Radic Biol Med (2011) 0.99
Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome. Cardiorenal Med (2012) 0.98
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev (2014) 0.98
Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Antioxid Redox Signal (2011) 0.97
Redox signaling pathways involved in neuronal ischemic preconditioning. Curr Neuropharmacol (2012) 0.95
Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. J Inflamm (Lond) (2010) 0.94
A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem (2014) 0.93
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
Nutrition facts in multiple sclerosis. ASN Neuro (2015) 0.91
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair. Redox Biol (2015) 0.88
Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance. PLoS One (2013) 0.88
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.87
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol (2012) 0.86
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. PLoS One (2011) 0.86
Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway. PLoS One (2014) 0.85
Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One (2013) 0.85
Tuftsin-driven experimental autoimmune encephalomyelitis recovery requires neuropilin-1. Glia (2016) 0.85
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A (2013) 0.84
Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. PLoS One (2013) 0.84
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis. Mol Cells (2015) 0.83
Protein glutathionylation in cardiovascular diseases. Int J Mol Sci (2013) 0.83
Role of microRNAs in Alcohol-Induced Multi-Organ Injury. Biomolecules (2015) 0.82
SIRT1 links CIITA deacetylation to MHC II activation. Nucleic Acids Res (2011) 0.82
Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Exp Neurol (2014) 0.82
Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. J Pathol (2014) 0.82
Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev (2015) 0.81
Sirtuin 1 signaling and alcoholic fatty liver disease. Hepatobiliary Surg Nutr (2015) 0.81
Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Proc Natl Acad Sci U S A (2017) 0.81
Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression. Cell Death Dis (2015) 0.80
The experimental autoimmune encephalomyelitis disease course is modulated by nicotine and other cigarette smoke components. PLoS One (2014) 0.79
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats. PLoS One (2013) 0.78
Ventilatory function in young adults and dietary antioxidant intake. Nutrients (2015) 0.77
Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration. Oncotarget (2015) 0.76
Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin. Open Biol (2014) 0.76
Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress. Cell Death Dis (2015) 0.76
Oxidative stress signaling to chromatin in health and disease. Epigenomics (2016) 0.76
The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. Oncogene (2016) 0.76
Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS One (2014) 0.76
SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium. Am J Transl Res (2016) 0.75
De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells. Oncotarget (2016) 0.75
Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep (2016) 0.75
Conditioned Medium from Early-Outgrowth Bone Marrow Cells Is Retinal Protective in Experimental Model of Diabetes. PLoS One (2016) 0.75
Vitamin D Receptor Deficit Induces Activation of Renin Angiotensin System Via SIRT1 Modulation in Podocytes. Exp Mol Pathol (2017) 0.75
Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. Proc Natl Acad Sci U S A (2017) 0.75
Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation. J Biol Chem (2016) 0.75
The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase. Toxicol Lett (2015) 0.75
Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging (Albany NY) (2016) 0.75
Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract-induced heme oxygenase-1 by cleaving sirtuin 1. J Biol Chem (2017) 0.75
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc (2006) 16.56
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A (2004) 10.78
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect (1985) 4.73
Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Role of oxidative carbonylation in protein quality control and senescence. EMBO J (2005) 3.59
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem (2005) 3.38
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem (2006) 3.18
Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr Opin Pharmacol (2007) 3.00
Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Am Rev Respir Dis (1978) 2.90
Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov (2008) 2.89
Spectrophotometric study of spontaneous disproportionation of superoxide anion radical and sensitive direct assay for superoxide dismutase. J Biol Chem (1976) 2.73
Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol (2008) 2.71
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol (2006) 2.70
Regulation of nuclear transport: central role in development and transformation? Traffic (2005) 2.51
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49
Protein adducts generated from products of lipid oxidation: focus on HNE and one. Drug Metab Rev (2006) 2.46
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med (2006) 2.20
Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med (2004) 2.19
Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun (2003) 2.15
Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol (2008) 2.07
Determination of toxic carbonyl compounds in cigarette smoke. Environ Toxicol (2006) 2.05
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite. J Biol Chem (2000) 1.97
Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res (2006) 1.89
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. Am J Physiol (1999) 1.87
Sirtuins: novel targets for metabolic disease. Curr Opin Investig Drugs (2008) 1.80
Aging and cigarette smoke: fueling the fire. Am J Respir Crit Care Med (2006) 1.76
Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. J Biol Chem (2004) 1.75
Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol (2007) 1.72
Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid Redox Signal (2006) 1.67
A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci (2007) 1.65
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol (2008) 1.64
Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications. Free Radic Biol Med (2007) 1.63
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.63
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci U S A (2008) 1.62
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol Gastrointest Liver Physiol (2009) 1.62
Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc Natl Acad Sci U S A (2005) 1.57
JNK2-dependent regulation of SIRT1 protein stability. Cell Cycle (2008) 1.56
Cytoplasm-localized SIRT1 enhances apoptosis. J Cell Physiol (2007) 1.52
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J (2009) 1.47
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43
Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 1.41
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am J Clin Nutr (1995) 1.39
H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion. Cell Physiol Biochem (2007) 1.36
Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. J Biol Chem (2007) 1.34
The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem Toxicol (2000) 1.32
Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol (2002) 1.28
Structural basis for sirtuin function: what we know and what we don't. Biochim Biophys Acta (2009) 1.26
Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic Biol Med (2007) 1.25
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochem Biophys Res Commun (2009) 1.23
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem (2009) 1.20
VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J (2008) 1.18
Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. J Biol Chem (2008) 1.17
Aging and induced senescence as factors in the pathogenesis of lung emphysema. Respir Med (2008) 1.14
Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.12
Redox proteomics: identification of oxidatively modified proteins. Proteomics (2003) 1.09
Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci (2008) 1.05
4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase. Free Radic Biol Med (2004) 1.05
Chronic obstructive pulmonary disease and premature aging. Am J Respir Crit Care Med (2007) 1.02
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. Antioxid Redox Signal (2008) 0.98
Free radical chemistry of cigarette smoke and its implication in human cancer. Anticancer Res (1997) 0.96
Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH). Eur Respir J (1998) 0.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab (2006) 3.35
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med (2007) 3.29
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol (2010) 3.08
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest (2012) 2.98
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell (2013) 2.92
Direct evidence for S-nitrosation of mitochondrial complex I. Biochem J (2006) 2.88
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol (2006) 2.70
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol (2006) 2.66
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med (2003) 2.28
Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol (2005) 2.28
Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J (2004) 2.14
Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther (2006) 2.05
The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J (2005) 2.05
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res (2006) 1.89
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2007) 1.85
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol (2004) 1.83
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
Cardioprotection by metabolic shut-down and gradual wake-up. J Mol Cell Cardiol (2009) 1.68
The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials (2008) 1.68
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol (2008) 1.64
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.63
Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol (2007) 1.59
Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem (2005) 1.59
Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal (2008) 1.57
Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med (2008) 1.56
Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal (2005) 1.54
Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem J (2006) 1.47
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A (2010) 1.44
Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol Heart Circ Physiol (2006) 1.43
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol (2009) 1.43
Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol (2009) 1.42
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol Lung Cell Mol Physiol (2002) 1.41
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection. Cardiovasc Res (2008) 1.41
Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem (2009) 1.41
Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic Res (2010) 1.38
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res (2010) 1.38
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. Am J Respir Cell Mol Biol (2003) 1.35
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol (2011) 1.35
Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition. Biochim Biophys Acta (2005) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning. Biochim Biophys Acta (2008) 1.33
Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ Res (2012) 1.31
Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. Am J Respir Cell Mol Biol (2008) 1.30
Mitochondria, nitric oxide, and cardiovascular dysfunction. Free Radic Biol Med (2002) 1.30
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest (2013) 1.29
The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res Cardiol (2009) 1.28
Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species. Trends Biochem Sci (2002) 1.27
Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxid Redox Signal (2008) 1.26
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol (2008) 1.25
Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol (2005) 1.22
Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. Biochem Biophys Res Commun (2004) 1.21
Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol (2006) 1.19
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol (2008) 1.19
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem (2002) 1.18
VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J (2008) 1.18
Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Am J Physiol Regul Integr Comp Physiol (2007) 1.18
Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res (2005) 1.17
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol (2008) 1.17
The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood (2012) 1.15
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med (2013) 1.15
Redox regulation of the mitochondrial K(ATP) channel in cardioprotection. Biochim Biophys Acta (2010) 1.12
Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Proc Natl Acad Sci U S A (2007) 1.11
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10
Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatr Res (2007) 1.09
Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function. Ann Surg (2008) 1.09
Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. Am J Physiol Lung Cell Mol Physiol (2007) 1.08
Mechanisms of the interaction of nitroxyl with mitochondria. Biochem J (2004) 1.07
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem (2009) 1.07
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
A cell-based phenotypic assay to identify cardioprotective agents. Circ Res (2012) 1.06