Published in J Cell Physiol on November 01, 2007
Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology (2011) 5.06
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev (2010) 3.77
Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol (2009) 3.55
Stem cells and liver regeneration. Gastroenterology (2009) 3.40
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest (2008) 2.89
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest (2011) 2.83
TGF-β in progression of liver disease. Cell Tissue Res (2011) 2.22
Cancer stem cells in the development of liver cancer. J Clin Invest (2013) 2.06
Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology (2010) 2.02
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell (2015) 1.89
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology (2010) 1.82
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int J Biol Sci (2011) 1.70
The three R's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest (2011) 1.68
MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology (2010) 1.64
Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology (2010) 1.64
Mir-33 regulates cell proliferation and cell cycle progression. Cell Cycle (2012) 1.60
Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents. Hepatology (2014) 1.59
Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med (2009) 1.58
Liver regeneration: alternative epithelial pathways. Int J Biochem Cell Biol (2009) 1.55
Evidence for novel hepaciviruses in rodents. PLoS Pathog (2013) 1.54
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (2009) 1.54
Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer (2010) 1.53
Current concepts of mechanisms in drug-induced hepatotoxicity. Curr Med Chem (2009) 1.50
Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol (2013) 1.49
Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A (2009) 1.47
Akt-mediated foxo1 inhibition is required for liver regeneration. Hepatology (2015) 1.46
Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers. Gastroenterology (2015) 1.44
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest (2012) 1.43
Molecular biology of liver cancer stem cells. Liver Cancer (2014) 1.41
Novel therapeutic strategies for targeting liver cancer stem cells. Int J Biol Sci (2011) 1.39
Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells. Dev Cell (2015) 1.38
YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle (2012) 1.34
Pluripotent stem cell-derived hepatocyte-like cells. Biotechnol Adv (2014) 1.33
Facultative stem cells in liver and pancreas: fact and fancy. Dev Dyn (2011) 1.32
Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab Invest (2008) 1.32
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (2008) 1.31
The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell (2012) 1.30
A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (2012) 1.29
Hepatic stem cell niches. J Clin Invest (2013) 1.29
Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol (2009) 1.28
Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology (2008) 1.27
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A (2010) 1.26
Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest (2013) 1.26
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem (2008) 1.26
Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways. Biol Chem (2009) 1.18
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2012) 1.17
Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest (2010) 1.15
The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver. Nat Protoc (2010) 1.14
Regulation of liver regeneration by growth factors and cytokines. EMBO Mol Med (2010) 1.14
Regulation of hepatocyte fate by interferon-γ. Cytokine Growth Factor Rev (2011) 1.13
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology (2009) 1.11
Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation. Am J Physiol Gastrointest Liver Physiol (2012) 1.10
Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. Am J Pathol (2012) 1.10
Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. FASEB J (2009) 1.09
CXC chemokine signaling in the liver: impact on repair and regeneration. Hepatology (2011) 1.07
The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology (2011) 1.07
Role of the Nrf2-ARE pathway in liver diseases. Oxid Med Cell Longev (2013) 1.07
Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat. BMC Genomics (2008) 1.07
Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. BMC Genomics (2013) 1.06
A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals. Hepatology (2013) 1.06
RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. Am J Pathol (2010) 1.05
Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration. Hepatology (2011) 1.05
Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging Cell (2010) 1.05
Hypoxia preconditioned bone marrow mesenchymal stem cells promote liver regeneration in a rat massive hepatectomy model. Stem Cell Res Ther (2013) 1.05
Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (2010) 1.04
Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells. Cell Tissue Res (2011) 1.04
TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. PLoS One (2014) 1.02
Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol (2009) 1.02
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology (2012) 1.02
Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol (2014) 1.01
Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice. Hepatology (2011) 1.01
T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology (2008) 1.01
Elucidating the metabolic regulation of liver regeneration. Am J Pathol (2013) 1.01
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. Front Pharmacol (2014) 1.01
Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration. PLoS One (2012) 1.00
Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch. Genes Dev (2010) 1.00
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice. Hepatology (2012) 1.00
FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology (2010) 1.00
Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. Biochem Biophys Res Commun (2008) 1.00
Cancer across the tree of life: cooperation and cheating in multicellularity. Philos Trans R Soc Lond B Biol Sci (2015) 1.00
p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology (2009) 0.99
Liver regeneration. Transl Res (2014) 0.99
Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays. Tissue Eng Part A (2011) 0.99
Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert Opin Drug Metab Toxicol (2009) 0.98
The liver is a peculiar organ when it comes to stem cells. Am J Pathol (2014) 0.98
Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. Am J Pathol (2009) 0.97
The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice. Gastroenterology (2012) 0.97
Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol (2009) 0.97
Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo. Cell Cycle (2009) 0.97
Enhanced liver regeneration in IL-10-deficient mice after partial hepatectomy via stimulating inflammatory response and activating hepatocyte STAT3. Am J Pathol (2011) 0.97
Functional Relationships between Lipid Metabolism and Liver Regeneration. Int J Hepatol (2012) 0.97
Keeping at arm's length during regeneration. Dev Cell (2014) 0.96
Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure. Hum Pathol (2012) 0.96
Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice. Hepatology (2011) 0.96
Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury. Int J Clin Exp Pathol (2013) 0.95
A model of liver regeneration. Biophys J (2009) 0.95
Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell (2012) 0.95
Liver regeneration. Science (1997) 12.80
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35
Bone marrow as a potential source of hepatic oval cells. Science (1999) 8.52
Liver regeneration. Hepatology (2006) 7.52
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature (2002) 7.28
Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70
Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol (2004) 6.36
The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov (2004) 6.21
Notch signaling: from the outside in. Dev Biol (2000) 6.06
Scatter factor/hepatocyte growth factor is essential for liver development. Nature (1995) 5.91
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (2006) 5.52
Liver regeneration. J Hepatol (2000) 5.22
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science (2003) 4.56
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A (1997) 4.33
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A (2004) 4.17
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest (2005) 4.07
Baboon-to-human liver transplantation. Lancet (1993) 4.01
The initiation of liver development is dependent on Foxa transcription factors. Nature (2005) 3.88
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene (1991) 3.41
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A (1995) 3.25
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol (1997) 3.15
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol (1996) 3.13
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature (2007) 3.11
Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology (2004) 3.09
Platelet-derived serotonin mediates liver regeneration. Science (2006) 2.98
Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A (2004) 2.77
Caveolin-1 is essential for liver regeneration. Science (2006) 2.77
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol (2001) 2.74
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Hepatology (2003) 2.68
Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science (2007) 2.64
Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology (2004) 2.62
Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol (1998) 2.62
In vivo differentiation of rat liver oval cells into hepatocytes. Cancer Res (1989) 2.58
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol (2002) 2.49
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem (2000) 2.46
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology (2005) 2.41
Regeneration of rat liver: transfer of humoral agent by cross circulation. Science (1967) 2.39
The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med (2003) 2.38
Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. Proc Natl Acad Sci U S A (1989) 2.35
Emerging multipotent aspects of hepatocyte growth factor. J Biochem (1996) 2.34
Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol (1992) 2.33
Liver regeneration 4: transcriptional control of liver regeneration. FASEB J (1996) 2.31
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem (2002) 2.28
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest (1998) 2.27
Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A (2006) 2.25
Control of hepatocyte replication by two serum factors. Cancer Res (1984) 2.20
Rapid activation of the Stat3 transcription complex in liver regeneration. Hepatology (1995) 2.17
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol (1993) 2.14
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology (2006) 2.08
Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res (2002) 2.05
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc Natl Acad Sci U S A (1988) 2.03
TGF-beta: regulation of extracellular matrix. Kidney Int (1992) 2.03
c-Met is essential for wound healing in the skin. J Cell Biol (2007) 1.98
Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology (1998) 1.96
An overview of the Notch signalling pathway. Semin Cell Dev Biol (2003) 1.93
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab Invest (1994) 1.90
Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology (1991) 1.88
The role of SF/HGF and c-Met in the development of skeletal muscle. Development (1999) 1.85
A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell (2002) 1.82
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (2005) 1.82
Expression of hepatic transcription factors during liver development and oval cell differentiation. J Cell Biol (1994) 1.80
Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology (1997) 1.79
Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ (1995) 1.75
Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J Cell Biol (2001) 1.74
PDGF and signal transduction in hepatic stellate cells. Front Biosci (2002) 1.74
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology (2005) 1.73
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology (1999) 1.72
Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology (2001) 1.71
Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol (1994) 1.65
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy. Hepatology (1999) 1.64
Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology (1998) 1.60
The physiology of transforming growth factor-alpha. Adv Cancer Res (1992) 1.56
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology (2007) 1.54
TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci (2003) 1.52
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J (1998) 1.50
Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology (2000) 1.50
Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis. Am J Pathol (2003) 1.50
Lessons from animal models of NASH. Hepatol Res (2005) 1.49
Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Cancer Res (1999) 1.48
Amnion-derived pluripotent/multipotent stem cells. Stem Cell Rev (2006) 1.48
Liver regeneration versus direct hyperplasia. FASEB J (1996) 1.47
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Proc Natl Acad Sci U S A (2004) 1.46
Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology (2001) 1.46
Identification of transcriptional networks during liver regeneration. J Biol Chem (2004) 1.46
Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol (1998) 1.45
Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res (1993) 1.45
Transcriptional control of wound repair. Annu Rev Cell Dev Biol (2007) 1.44
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Proc Natl Acad Sci U S A (1998) 1.44
Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol (2001) 1.44
Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology (2005) 1.44
Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem (2004) 1.44
Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine. Science (1985) 1.43
Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Hepatology (2001) 1.42
Liver regeneration. Adv Biochem Eng Biotechnol (2005) 1.42
HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol (1999) 1.41
Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis (1999) 1.41
Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. Cell Growth Differ (1993) 1.38