Published in Brain Res on June 02, 2007
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Proc Natl Acad Sci U S A (2008) 1.74
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS One (2011) 1.34
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
TRPA1 and cold transduction: an unresolved issue? J Gen Physiol (2009) 1.30
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain (2010) 1.25
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun (2013) 1.20
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. Mol Pain (2007) 1.19
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. PLoS One (2009) 1.18
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol (2009) 1.09
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain. Proc Natl Acad Sci U S A (2014) 1.07
Converting cold into pain. Exp Brain Res (2009) 1.06
Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron (2014) 1.05
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am J Physiol Cell Physiol (2008) 1.00
Homeostatic function of astrocytes: Ca(2+) and Na(+) signalling. Transl Neurosci (2012) 0.99
Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience (2008) 0.98
Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci (2008) 0.95
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
TRPA1: the species difference. J Gen Physiol (2009) 0.92
The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J Physiol (2013) 0.90
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation. Pflugers Arch (2013) 0.89
TRP channels: sensors and transducers of gasotransmitter signals. Front Physiol (2012) 0.88
Effects of hot and cold stimulus combinations on the thermal preference of rats. Behav Brain Res (2009) 0.87
C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel. J Biol Chem (2012) 0.87
Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling. J Nat Sci Biol Med (2011) 0.86
The dynamic TRPA1 channel: a suitable pharmacological pain target? Curr Pharm Biotechnol (2011) 0.84
Species-specific temperature sensitivity of TRPA1. Temperature (Austin) (2015) 0.84
Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors. Neuroscience (2009) 0.82
TRPA1 as a drug target--promise and challenges. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.82
Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation. J Biol Chem (2012) 0.81
TRPs and pain. Semin Immunopathol (2015) 0.80
Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1. Pflugers Arch (2012) 0.80
A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies. Commun Integr Biol (2009) 0.79
Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain (2014) 0.78
Structure of thermally activated TRP channels. Curr Top Membr (2014) 0.78
The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. PLoS One (2014) 0.77
TRPM3 in temperature sensing and beyond. Temperature (Austin) (2015) 0.76
The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive. Temperature (Austin) (2015) 0.75
Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8. Temperature (Austin) (2015) 0.75
Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms. Biophys Rev (2009) 0.75
The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor. J Biol Chem (2016) 0.75
TRPA1 mediates amplified sympathetic responsiveness to activation of metabolically sensitive muscle afferents in rats with femoral artery occlusion. Front Physiol (2015) 0.75
Temperature receptors in cutaneous nerve endings are thermostat molecules that induce thermoregulatory behaviors against thermal load. Temperature (Austin) (2015) 0.75
High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study. Arterioscler Thromb Vasc Biol (2008) 1.98
Cellular and molecular bases of the initiation of fever. PLoS Biol (2006) 1.98
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. J Neurosci (2005) 1.86
Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. J Hypertens (2005) 1.86
Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension (2004) 1.85
Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci (2004) 1.69
Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study. J Hypertens (2012) 1.60
Point: Heat-induced membrane depolarization of hypothalamic neurons: a putative mechanism of central thermosensitivity. Am J Physiol Regul Integr Comp Physiol (2006) 1.54
Association of serum uric acid with blood pressure in Japanese men. Cross-sectional study in work-site group. Circ J (2011) 1.53
Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur J Neurosci (2005) 1.50
The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci (2002) 1.48
Salt intake in 3-year-old Japanese children. Hypertens Res (2011) 1.45
Efficacy and safety of once-daily oxybutynin patch versus placebo and propiverine in Japanese patients with overactive bladder: A randomized double-blind trial. Int J Urol (2013) 1.42
Development and validation of a cardiovascular risk prediction model for Japanese: the Hisayama study. Hypertens Res (2009) 1.41
Activation of transient receptor potential ankyrin 1 by hydrogen peroxide. Eur J Neurosci (2008) 1.37
Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS One (2011) 1.34
Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci Lett (2005) 1.25
TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res (2005) 1.21
Attenuated fever in pregnant rats is associated with blunted syntheses of brain cyclooxygenase-2 and PGE2. Am J Physiol Regul Integr Comp Physiol (2002) 1.11
Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3. Eur J Neurosci (2003) 1.08
Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region. Neurosci Res (2006) 1.05
Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain. Neuroimage (2002) 1.05
Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci Res (2005) 1.04
Prediction of cognitive function by arterial stiffness in the very elderly. Circ J (2006) 1.01
Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. Am J Physiol Regul Integr Comp Physiol (2007) 1.01
Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int (2007) 0.98
Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. J Neurochem (2003) 0.97
Noxious heat receptors present in cold-sensory cells in rats. Neurosci Lett (2004) 0.96
Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40. J Biol Chem (2003) 0.96
Role of lactate in the brain energy metabolism: revealed by Bioradiography. Neurosci Res (2004) 0.96
Ionic basis of cold receptors acting as thermostats. J Neurosci (2002) 0.96
Impact of blood pressure levels on different types of stroke: the Hisayama study. J Hypertens (2009) 0.96
QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study. Hypertens Res (2010) 0.96
Central and peripheral cardiovascular actions of apelin in conscious rats. Regul Pept (2005) 0.95
Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever. Neurosci Res (2002) 0.93
Signaling the brain in inflammation: the role of endothelial cells. Front Biosci (2004) 0.93
Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules. Hypertension (2009) 0.93
Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. J Neurosci Res (2010) 0.91
Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology (2007) 0.91
Cells that trigger fever. Cell Cycle (2006) 0.90
White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama study. Stroke (2013) 0.90
Central cardiovascular action of urotensin II in conscious rats. J Hypertens (2003) 0.90
Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels. Neurochem Int (2011) 0.88
Anomalous origin of the right coronary artery from the left sinus of valsalva: diagnosis by multiplane transesophageal echocardiography. Echocardiography (2002) 0.87
Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6. J Comp Neurol (2005) 0.87
Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain. Neurosci Lett (2005) 0.86
Burn injury enhances brain prostaglandin E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin E synthase in cerebral vascular endothelial cells in rats. Crit Care Med (2004) 0.86
Chronic administration of olmesartan attenuates the exaggerated pressor response to glutamate in the rostral ventrolateral medulla of SHR. Brain Res (2005) 0.86
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. J Cell Sci (2006) 0.86
Role of ERK and Rho kinase pathways in central pressor action of urotensin II. J Hypertens (2004) 0.85
Clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. Clin Exp Hypertens (2013) 0.83
Central cardiovascular action of urotensin II in spontaneously hypertensive rats. Hypertens Res (2003) 0.83
Chronic kidney disease increases cardiovascular mortality in 80-year-old subjects in Japan. Hypertens Res (2008) 0.82
Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension. DNA Repair (Amst) (2007) 0.82
Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice. Regul Pept (2009) 0.82
Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice. Am J Physiol Regul Integr Comp Physiol (2011) 0.82
Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. Intern Med (2007) 0.82
Aldosterone-and-salt-induced cardiac fibrosis is independent from angiotensin II type 1a receptor signaling in mice. Hypertens Res (2007) 0.81
Effects of the superoxide dismutase mimetic tempol on impaired endothelium-dependent and endothelium-independent relaxations in type II diabetic rats. Clin Exp Hypertens (2012) 0.80
Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats. J Neurosci Res (2008) 0.80
Association between blood pressure and mortality in 80-year-old subjects from a population-based prospective study in Japan. Hypertens Res (2008) 0.80
In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. J Nucl Med (2011) 0.80
Spontaneous hemothorax caused by intrathoracic synovial sarcoma. Jpn J Thorac Cardiovasc Surg (2006) 0.80
Renal and carotid vascular resistance assessed with Doppler sonography. J Clin Ultrasound (2008) 0.79
Chronic central infusion of orexin-A increases arterial pressure in rats. Brain Res Bull (2002) 0.79
Does decreased diastolic blood pressure associate with increased mortality in 80-year-old Japanese? Clin Exp Hypertens (2009) 0.79
Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes. Arterioscler Thromb Vasc Biol (2013) 0.79
Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of Dahl salt-sensitive hypertensive rats. Hypertens Res (2012) 0.79
Sensory stimuli induce nuclear translocation and phosphorylation of nuclear factor κ B in primary sensory neurons of mice. Neurosci Res (2011) 0.78
The distribution of transient receptor potential melastatin-8 in the rat soft palate, epiglottis, and pharynx. Cell Mol Neurobiol (2012) 0.77