Published in J Neurosci on September 24, 2008
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Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 2.47
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature (2010) 2.35
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Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
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Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol (2009) 1.33
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CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PLoS One (2012) 1.20
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Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol (2009) 1.09
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain (2013) 1.09
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Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron (2014) 1.05
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A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol (2014) 0.93
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J (2010) 0.93
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem (2010) 0.93
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Sweet taste and menthol increase cough reflex thresholds. Pulm Pharmacol Ther (2012) 0.92
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Are sensory TRP channels biological alarms for lipid peroxidation? Int J Mol Sci (2014) 0.83
Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity. J Physiol Sci (2014) 0.82
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Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation. Pflugers Arch (2013) 0.82
Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun (2016) 0.81
Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. Chem Senses (2011) 0.81
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Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease. Pain (2016) 0.79
Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor. Mol Pain (2012) 0.79
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Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons. Neuroscience (2012) 0.79
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Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps mercedesae. Open Biol (2016) 0.77
The Outer Pore and Selectivity Filter of TRPA1. PLoS One (2016) 0.77
Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Biosci Rep (2014) 0.77
The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. PLoS One (2014) 0.77
Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels. Curr Neuropharmacol (2015) 0.76
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When Choice Makes Sense: Menthol Influence on Mating, Oviposition and Fecundity in Drosophila melanogaster. Front Integr Neurosci (2016) 0.75
Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. Sci Rep (2016) 0.75
Identification of a putative binding site critical for general anesthetic activation of TRPA1. Proc Natl Acad Sci U S A (2017) 0.75
Channels: flies feel your pain. Nat Chem Biol (2010) 0.75
The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor. J Biol Chem (2016) 0.75
4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities. Sci Rep (2017) 0.75
TRPA1 Channels in Drosophila and Honey Bee Ectoparasitic Mites Share Heat Sensitivity and Temperature-Related Physiological Functions. Front Physiol (2016) 0.75
Olfactory and trigeminal interaction of menthol and nicotine in humans. Exp Brain Res (2012) 0.75
Taurolidine and congeners activate hTRPA1 but not hTRPV1 channels and stimulate CGRP release from mouse tracheal sensory nerves. Pharmacol Res Perspect (2016) 0.75
Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug Alcohol Depend (2017) 0.75
Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates. Temperature (Austin) (2017) 0.75
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (2002) 8.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
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Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
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Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem (2007) 2.89
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Thymol and related alkyl phenols activate the hTRPA1 channel. Br J Pharmacol (2008) 1.04
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