Published in Proc Natl Acad Sci U S A on June 25, 2007
The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron (2013) 2.59
Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J Neurosci (2010) 2.25
Dendritic spine pathology in schizophrenia. Neuroscience (2012) 1.91
High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy. Nat Protoc (2011) 1.59
Estrogen shapes dopamine-dependent cognitive processes: implications for women's health. J Neurosci (2011) 1.55
Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. J Neurosci (2014) 1.53
Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci (2009) 1.47
Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr Rev (2009) 1.33
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex. J Neurosci (2011) 1.32
Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathway. Cereb Cortex (2010) 1.26
Perimenopausal regulation of steroidogenesis in the nonhuman primate. Neurobiol Aging (2011) 1.17
Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery. Neurobiol Aging (2008) 1.17
Estrogen and the prefrontal cortex: towards a new understanding of estrogen's effects on executive functions in the menopause transition. Hum Brain Mapp (2012) 1.12
Synaptic estrogen receptor-alpha levels in prefrontal cortex in female rhesus monkeys and their correlation with cognitive performance. J Neurosci (2010) 1.09
Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging. Neuroscience (2011) 1.06
Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest. Brain Res (2009) 1.05
Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions. Eur J Neurosci (2012) 1.04
Dendritic spine changes associated with normal aging. Neuroscience (2012) 1.03
Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci U S A (2013) 1.03
Estrogen and the aging brain: an elixir for the weary cortical network. Ann N Y Acad Sci (2010) 1.02
Role of androgens and the androgen receptor in remodeling of spine synapses in limbic brain areas. Horm Behav (2007) 1.01
Insights into rapid modulation of neuroplasticity by brain estrogens. Pharmacol Rev (2013) 0.99
Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke. Horm Behav (2012) 0.99
Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys. Neurobiol Aging (2010) 0.98
Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) (2011) 0.97
Differential effects on visual and spatial recognition memory of a novel hormone therapy regimen of estrogen alone or combined with progesterone in older surgically menopausal monkeys. Neuroscience (2008) 0.97
Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A (2013) 0.97
Role of circadian neuroendocrine rhythms in the control of behavior and physiology. Neuroendocrinology (2011) 0.95
Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Res (2008) 0.95
Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse. Physiol Rev (2015) 0.95
Dehydroepiandrosterone and age-related cognitive decline. Age (Dordr) (2009) 0.93
Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia. Mol Psychiatry (2015) 0.92
Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia. Neuropsychopharmacology (2015) 0.92
Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque. J Neurosci (2016) 0.91
Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Mol Psychiatry (2013) 0.91
Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. J Comp Neurol (2012) 0.91
Chronic estradiol replacement impairs performance on an operant delayed spatial alternation task in young, middle-aged, and old rats. Horm Behav (2009) 0.90
Session II: Mechanisms of age-related cognitive change and targets for intervention: neural circuits, networks, and plasticity. J Gerontol A Biol Sci Med Sci (2012) 0.90
Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause. Am J Primatol (2009) 0.88
Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons. J Neurosci (2011) 0.87
Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys. J Neurosci (2012) 0.86
Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys. Neurobiol Aging (2013) 0.84
Rapid estradiol modulation of neuronal connectivity and its implications for disease. Front Endocrinol (Lausanne) (2011) 0.83
G-protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment. J Exp Zool A Ecol Genet Physiol (2014) 0.82
Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res (2011) 0.81
Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. Front Endocrinol (Lausanne) (2011) 0.81
Effects of hormone therapy on cognition and mood. Fertil Steril (2014) 0.81
Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: effect of neuronal activation. J Comp Neurol (2008) 0.81
Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience (2014) 0.80
Primate models of schizophrenia: future possibilities. Prog Brain Res (2009) 0.80
Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys. J Neurosci (2016) 0.78
Hormone therapy does not modify emotion-induced brain activity in older women. Horm Behav (2009) 0.77
No effect of different estrogen receptor ligands on cognition in adult female monkeys. Physiol Behav (2008) 0.77
Ovarian adrenal interactions during the menopausal transition. Minerva Ginecol (2013) 0.77
Continuously delivered ovarian steroids do not alter dendritic spine density or morphology in macaque dorsolateral prefrontal cortical neurons. Neuroscience (2013) 0.77
Understanding the broad influence of sex hormones and sex differences in the brain. J Neurosci Res (2017) 0.77
Actions and interactions of estradiol and glucocorticoids in cognition and the brain: Implications for aging women. Neurosci Biobehav Rev (2015) 0.76
Ovarian steroids increase PSD-95 expression and dendritic spines in the dorsal raphe of ovariectomized macaques. Synapse (2013) 0.76
The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1. Genome Biol (2015) 0.76
Environmental estrogens impact primate brain. Proc Natl Acad Sci U S A (2008) 0.76
GnRH neurons of young and aged female rhesus monkeys co-express GPER but are unaffected by long-term hormone replacement. Neuroendocrinology (2014) 0.76
Age and Long-Term Hormone Treatment Effects on the Ultrastructural Morphology of the Median Eminence of Female Rhesus Macaques. Neuroendocrinology (2015) 0.75
Sex in the brain: hormones and sex differences. Dialogues Clin Neurosci (2016) 0.75
Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders. J Pharmacol Exp Ther (2016) 0.75
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85
Transient and persistent dendritic spines in the neocortex in vivo. Neuron (2005) 6.30
Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J Neurosci (1989) 5.58
The prefrontal cortex and cognitive control. Nat Rev Neurosci (2000) 5.46
Structure-stability-function relationships of dendritic spines. Trends Neurosci (2003) 4.80
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Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Neuron (2005) 4.05
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nat Neurosci (1999) 3.99
Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci (1992) 3.56
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci (1990) 3.47
Estrogen actions throughout the brain. Recent Prog Horm Res (2002) 3.17
Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neurosci (2003) 2.40
Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci (1997) 2.39
Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism. J Neurosci (1994) 2.33
Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys. J Neurosci (2006) 2.24
Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging (2000) 2.08
Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. J Neurosci (2006) 1.95
Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons. J Neurosci (1998) 1.86
Different modes of hippocampal plasticity in response to estrogen in young and aged female rats. Proc Natl Acad Sci U S A (2001) 1.64
Neuroendocrine changes in the aging reproductive axis of female rhesus macaques (Macaca mulatta). Biol Reprod (2006) 1.56
Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys. J Comp Neurol (2003) 1.49
Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. J Neurosci (1996) 1.48
Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys. Cereb Cortex (2004) 1.48
Automated reconstruction of three-dimensional neuronal morphology from laser scanning microscopy images. Methods (2003) 1.47
Immunogold localization of AMPA and NMDA receptors in somatic sensory cortex of albino rat. J Comp Neurol (1999) 1.45
Estrogen and cognitive aging in women. Neuroscience (2005) 1.44
Hormone therapy and cognitive function: is there a critical period for benefit? Neuroscience (2006) 1.36
The cognitive effects of ovariectomy and estrogen replacement are modulated by aging. Neuroscience (2003) 1.32
Characterization of the onset of menopause in the rhesus macaque. Biol Reprod (1997) 1.32
Neurofilament protein defines regional patterns of cortical organization in the macaque monkey visual system: a quantitative immunohistochemical analysis. J Comp Neurol (1995) 1.30
Estrogen and cognition: applying preclinical findings to clinical perspectives. J Neurosci Res (2003) 1.27
Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal subfield of female nonhuman primates. J Comp Neurol (2002) 1.21
Effects of ovarian hormones on cognitive function in nonhuman primates. Neuroscience (2005) 1.09
Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task. Horm Behav (2002) 1.09
The "psychic" neuron of the cerebral cortex. Ann N Y Acad Sci (1999) 1.08
Ovarian hormones differentially influence immunoreactivity for dopamine beta- hydroxylase, choline acetyltransferase, and serotonin in the dorsolateral prefrontal cortex of adult rhesus monkeys. J Comp Neurol (1999) 0.99
Estrogen modulates cognitive and cholinergic processes in surgically menopausal monkeys. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.99
Effects of two years of estrogen loss or replacement on nucleus basalis cholinergic neurons and cholinergic fibers to the dorsolateral prefrontal and inferior parietal cortex of monkeys. J Comp Neurol (2004) 0.98
Estrogen and the cholinergic system modulate visuospatial attention in monkeys (Macaca fascicularis). Behav Neurosci (2002) 0.98
Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats. Exp Neurol (2001) 0.97
The effects of long-term ovariectomy and estrogen replacement therapy on learning and memory in monkeys (Macaca fascicularis). Behav Neurosci (2000) 0.96
White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry (2003) 4.25
Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci (2006) 3.96
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77
Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol (2014) 3.75
Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. PLoS One (2008) 3.74
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb Cortex (2005) 3.71
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Geometry and structural plasticity of synaptic connectivity. Neuron (2002) 3.23
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci (2010) 3.02
Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation (2005) 3.01
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci (2005) 2.94
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles. Proc Natl Acad Sci U S A (2004) 2.74
New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65
Minicolumnar abnormalities in autism. Acta Neuropathol (2006) 2.62
The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron (2013) 2.59
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J (2004) 2.56
Variability of Broca's area homologue in African great apes: implications for language evolution. Anat Rec A Discov Mol Cell Evol Biol (2003) 2.52
Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab (2003) 2.47
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron (2013) 2.46
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci (2003) 2.42
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A (2003) 2.41
Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neurosci (2003) 2.40
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proc Natl Acad Sci U S A (2004) 2.39
Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy images. Nat Protoc (2006) 2.38
Neuropathological findings in autism. Brain (2004) 2.34
Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell (2012) 2.29
Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J Neurosci (2010) 2.25
Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys. J Neurosci (2006) 2.24
IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci (2011) 2.15
Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients. Am J Psychiatry (2008) 2.11
The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci (2004) 2.10
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex. J Comp Neurol (2008) 2.07
The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus. Arthritis Rheum (2010) 2.06
Cytoarchitecture of the human cerebral cortex: MR microscopy of excised specimens at 9.4 Tesla. AJNR Am J Neuroradiol (2002) 1.98
Changes in the structural complexity of the aged brain. Aging Cell (2007) 1.96
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J (2005) 1.90
Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress. Exp Neurol (2005) 1.89
Functional trade-offs in white matter axonal scaling. J Neurosci (2008) 1.88
Clinicopathological validation study of four sets of clinical criteria for vascular dementia. Am J Psychiatry (2002) 1.88
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A (2003) 1.86
In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. Front Neuroanat (2008) 1.85
Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque. J Neurosci (2008) 1.84
Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys. Cereb Cortex (2003) 1.83
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proc Natl Acad Sci U S A (2011) 1.82
Evolution of increased glia-neuron ratios in the human frontal cortex. Proc Natl Acad Sci U S A (2006) 1.77
Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke (2004) 1.74
Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain. Proc Natl Acad Sci U S A (2008) 1.73
The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struct Funct (2010) 1.71
Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A (2012) 1.64
Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus. Kidney Int (2011) 1.63
Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology (2007) 1.63
Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats. J Neurosci (2002) 1.61
High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy. Nat Protoc (2011) 1.59
Cetaceans have complex brains for complex cognition. PLoS Biol (2007) 1.55
Entorhinal cortex lesions disrupt the relational organization of memory in monkeys. J Neurosci (2004) 1.55
Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm? J Neurol Sci (2007) 1.52
Nerve conduction studies and current perception thresholds in workers assessed for hand-arm vibration syndrome. Occup Med (Lond) (2007) 1.52
Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes. Proc Natl Acad Sci U S A (2010) 1.51
Neurons in the fusiform gyrus are fewer and smaller in autism. Brain (2008) 1.50
Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys. J Comp Neurol (2003) 1.49
Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys. Cereb Cortex (2004) 1.48
Automated reconstruction of three-dimensional neuronal morphology from laser scanning microscopy images. Methods (2003) 1.47
Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific. Cereb Cortex (2009) 1.46
The functional integration of the anterior cingulate cortex during conflict processing. Cereb Cortex (2007) 1.45
A longitudinal study to explain the pain-depression link in older adults with osteoarthritis. Arthritis Care Res (Hoboken) (2010) 1.45
Repeated stress and structural plasticity in the brain. Ageing Res Rev (2005) 1.43
Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res (2002) 1.43
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol (2009) 1.42
Scaling laws in the mammalian neocortex: does form provide clues to function? J Neurocytol (2003) 1.41
Evolution of the brainstem orofacial motor system in primates: a comparative study of trigeminal, facial, and hypoglossal nuclei. J Hum Evol (2004) 1.40
Adenosine and sleep homeostasis in the Basal forebrain. J Neurosci (2006) 1.40
Anterior insular cortex and emotional awareness. J Comp Neurol (2013) 1.40
The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol (2004) 1.40
Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis. Biol Reprod (2012) 1.39