Published in FEMS Immunol Med Microbiol on June 26, 2007
Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother (2009) 1.60
Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection. PLoS Pathog (2009) 1.24
Genetics of Borrelia burgdorferi. Annu Rev Genet (2012) 1.21
Microbial antigenic variation mediated by homologous DNA recombination. FEMS Microbiol Rev (2012) 1.18
Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi. PLoS Pathog (2009) 1.09
Variable VlsE is critical for host reinfection by the Lyme disease spirochete. PLoS One (2013) 0.96
vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity. Microbiol Spectr (2014) 0.84
A critical appraisal of "chronic Lyme disease". N Engl J Med (2007) 7.84
Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J Infect Dis (2003) 3.18
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc Natl Acad Sci U S A (2004) 2.60
An immune evasion mechanism for spirochetal persistence in Lyme borreliosis. J Exp Med (2002) 2.25
Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol (2008) 2.23
Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis. Arthritis Rheum (2007) 2.20
BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect Immun (2004) 2.08
Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection. PLoS One (2012) 2.01
Decreased electroporation efficiency in Borrelia burgdorferi containing linear plasmids lp25 and lp56: impact on transformation of infectious B. burgdorferi. Infect Immun (2002) 1.83
Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi. Infect Immun (2008) 1.67
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. J Biol Chem (2002) 1.62
Intact flagellar motor of Borrelia burgdorferi revealed by cryo-electron tomography: evidence for stator ring curvature and rotor/C-ring assembly flexion. J Bacteriol (2009) 1.61
Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus. J Immunol (2004) 1.52
Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease. Diagn Microbiol Infect Dis (2012) 1.45
Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res (2003) 1.44
Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain. Mediators Inflamm (2013) 1.43
Chronic binge ethanol consumption accelerates progression of simian immunodeficiency virus disease. Alcohol Clin Exp Res (2006) 1.40
Identification of an ospC operator critical for immune evasion of Borrelia burgdorferi. Mol Microbiol (2007) 1.33
Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infect Immun (2005) 1.30
The genome sequence of Lone Star virus, a highly divergent bunyavirus found in the Amblyomma americanum tick. PLoS One (2013) 1.30
Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection. J Bacteriol (2005) 1.30
Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol (2008) 1.29
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog (2010) 1.29
Constitutive expression of outer surface protein C diminishes the ability of Borrelia burgdorferi to evade specific humoral immunity. Infect Immun (2006) 1.28
A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Infect Immun (2008) 1.28
Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis (2012) 1.27
Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proc Natl Acad Sci U S A (2003) 1.26
Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection. PLoS Pathog (2009) 1.24
Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1. Infect Immun (2004) 1.22
Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol (2010) 1.22
Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity. PLoS One (2012) 1.19
Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis. Am J Pathol (2008) 1.19
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding. J Biol Chem (2004) 1.17
2-tiered antibody testing for early and late Lyme disease using only an immunoglobulin G blot with the addition of a VlsE band as the second-tier test. Clin Infect Dis (2010) 1.15
Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. Infect Genet Evol (2011) 1.15
Genome scale identification of Treponema pallidum antigens. Infect Immun (2005) 1.14
Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations. Infect Immun (2004) 1.14
Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity. Mol Microbiol (2010) 1.12
Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi. Clin Diagn Lab Immunol (2004) 1.12
A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential. Infect Immun (2004) 1.12
Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. J Med Microbiol (2002) 1.11
Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J Clin Microbiol (2006) 1.11
Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway. Infect Immun (2009) 1.11
Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Infect Immun (2008) 1.10
A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae. Vaccine (2011) 1.10
Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi. PLoS Pathog (2009) 1.09
Identification of potential virulence determinants by Himar1 transposition of infectious Borrelia burgdorferi B31. Infect Immun (2006) 1.08
Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing. Infect Immun (2013) 1.08
Possible role of glial cells in the onset and progression of Lyme neuroborreliosis. J Neuroinflammation (2009) 1.06
Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule. Clin Vaccine Immunol (2007) 1.05
Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins. Infect Immun (2002) 1.05
Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay. PLoS One (2011) 1.05
The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice. Infect Immun (2006) 1.05
Glycerophosphodiester phosphodiesterase gene (glpQ) of Borrelia lonestari identified as a target for differentiating Borrelia species associated with hard ticks (Acari:Ixodidae). J Clin Microbiol (2004) 1.05
Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A. Infect Immun (2007) 1.04
Increasing the recruitment of neutrophils to the site of infection dramatically attenuates Borrelia burgdorferi infectivity. J Immunol (2007) 1.03
Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease. Clin Infect Dis (2008) 1.03
Significant improvement of the recombinant Borrelia-specific immunoglobulin G immunoblot test by addition of VlsE and a DbpA homologue derived from Borrelia garinii for diagnosis of early neuroborreliosis. J Clin Microbiol (2003) 1.02
Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2013) 1.02
Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice. Infect Immun (2003) 1.02
Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3. Infect Immun (2006) 1.01
Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease. Microbes Infect (2004) 1.00
Molecular architecture of the bacterial flagellar motor in cells. Biochemistry (2014) 1.00
Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination. Infect Immun (2007) 0.99
Common and unique contributions of decorin-binding proteins A and B to the overall virulence of Borrelia burgdorferi. PLoS One (2008) 0.99
The use of cross-foster rederivation to eliminate murine norovirus, Helicobacter spp., and murine hepatitis virus from a mouse colony. J Am Assoc Lab Anim Sci (2008) 0.99
Assessment of the nasopharyngeal bacterial flora of rhesus macaques: moraxella, Neisseria, haemophilus, and other genera. J Clin Microbiol (2002) 0.99
Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection. PLoS One (2010) 0.99
BAC library of T. pallidum DNA in E. coli. Genome Res (2002) 0.98
Molecular studies in Treponema pallidum evolution: toward clarity? PLoS Negl Trop Dis (2008) 0.98
Characterization of a Moraxella species that causes epistaxis in macaques. Vet Microbiol (2010) 0.98
Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes. Eur J Immunol (2003) 0.98
A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi. J Neuroinflammation (2012) 0.97
Multiplex immunoassay for Lyme disease using VlsE1-IgG and pepC10-IgM antibodies: improving test performance through bioinformatics. Clin Vaccine Immunol (2011) 0.97
DNA evidence of Borrelia lonestari in Amblyomma americanum (Acari: Ixodidae) in southeast Missouri. J Med Entomol (2003) 0.96
Transcriptional regulation of the Borrelia burgdorferi antigenically variable VlsE surface protein. J Bacteriol (2006) 0.96
Effects of weekly blood collection in C57BL/6 mice. J Am Assoc Lab Anim Sci (2011) 0.96
The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi. J Infect Dis (2009) 0.95