Published in Free Radic Biol Med on March 31, 2007
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol (2008) 4.12
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med (2009) 4.05
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37
Strategies for treating idiopathic pulmonary fibrosis. Nat Rev Drug Discov (2010) 3.20
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res (2009) 2.83
NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal (2009) 2.29
Oxidative stress in prostate cancer. Cancer Lett (2009) 2.28
Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol (2009) 2.26
Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov (2009) 2.24
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med (2009) 2.04
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal (2015) 2.02
Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol (2011) 1.97
Biological roles for the NOX family NADPH oxidases. J Biol Chem (2008) 1.96
Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am J Pathol (2008) 1.93
Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev (2008) 1.91
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis (2011) 1.79
Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med (2009) 1.77
Threats to the mind: aging, amyloid, and hypertension. Stroke (2008) 1.68
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. Blood (2010) 1.68
Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Pharmacol Ther (2010) 1.66
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol (2012) 1.60
NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med (2007) 1.50
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med (2009) 1.45
Redox control of renal function and hypertension. Antioxid Redox Signal (2008) 1.45
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2. Oxid Med Cell Longev (2016) 1.40
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse. Am J Respir Crit Care Med (2011) 1.36
Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36
Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal (2008) 1.35
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med (2008) 1.33
Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair (2008) 1.30
Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal (2009) 1.29
NOX enzymes and pulmonary disease. Antioxid Redox Signal (2009) 1.29
Nox5 and the regulation of cellular function. Antioxid Redox Signal (2009) 1.28
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med (2010) 1.28
Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J (2011) 1.25
Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol (2011) 1.24
Good stress, bad stress--the delicate balance in the vasculature. Dtsch Arztebl Int (2009) 1.23
NOX activity is increased in mild cognitive impairment. Antioxid Redox Signal (2010) 1.22
Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda) (2010) 1.22
NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol (2009) 1.20
c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. Mol Biol Cell (2010) 1.20
Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol (2007) 1.17
Tissue elasticity and the ageing elastic fibre. Age (Dordr) (2009) 1.14
Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol (2012) 1.14
Reactive oxygen species in phagocytic leukocytes. Histochem Cell Biol (2008) 1.14
Botanical phenolics and brain health. Neuromolecular Med (2008) 1.11
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol (2008) 1.11
Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med (2012) 1.11
Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells. Biol Reprod (2009) 1.09
Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2008) 1.09
Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal (2014) 1.09
Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem (2009) 1.08
From form to function: the role of Nox4 in the cardiovascular system. Front Physiol (2012) 1.07
Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol (2012) 1.07
Reactive oxygen species in normal and tumor stem cells. Adv Cancer Res (2014) 1.06
Oxygen in the evolution of complex life and the price we pay. Am J Respir Cell Mol Biol (2008) 1.05
Translating the oxidative stress hypothesis into the clinic: NOX versus NOS. J Mol Med (Berl) (2009) 1.05
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell (2008) 1.05
Enhanced ROS production and redox signaling with combined arsenite and UVA exposure: contribution of NADPH oxidase. Free Radic Biol Med (2009) 1.05
NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem (2010) 1.04
New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs (2011) 1.03
Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production. Arterioscler Thromb Vasc Biol (2012) 1.03
Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. Free Radic Biol Med (2012) 1.02
SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases. Arterioscler Thromb Vasc Biol (2011) 1.02
Oxidative stress in the cardiorenal metabolic syndrome. Curr Hypertens Rep (2012) 1.02
Reactive oxygen species regulate F-actin dynamics in neuronal growth cones and neurite outgrowth. J Neurochem (2008) 1.02
NADPH-oxidase activation and cognition in Alzheimer disease progression. Free Radic Biol Med (2011) 1.01
Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration. J Biol Chem (2009) 1.01
The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis. Sci Signal (2013) 1.01
The biological significance of methionine sulfoxide stereochemistry. Free Radic Biol Med (2010) 0.99
Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013) 0.98
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Am J Physiol Endocrinol Metab (2012) 0.98
The intimate and mysterious relationship between proton channels and NADPH oxidase. FEBS Lett (2008) 0.97
Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5. Mol Pharmacol (2011) 0.97
NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis (2011) 0.97
NOX activity in brain aging: exacerbation by high fat diet. Free Radic Biol Med (2010) 0.97
NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS. Cell Mol Life Sci (2012) 0.96
Differential roles of NADPH oxidases in vascular physiology and pathophysiology. Front Biosci (Schol Ed) (2012) 0.95
NADPH oxidase expression and production of superoxide by human corneal stromal cells. Mol Vis (2009) 0.95
Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta (2014) 0.94
Retracted Reactive oxygen species and tumor metastasis. Mol Cells (2013) 0.94
Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. Am J Physiol Renal Physiol (2009) 0.94
Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol (2010) 0.94
Molecular regulation of NADPH oxidase 5 via the MAPK pathway. Am J Physiol Heart Circ Physiol (2011) 0.93
Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase. Mol Cell Neurosci (2009) 0.92
Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiol Dis (2011) 0.91
ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation. Free Radic Biol Med (2014) 0.91
Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death. J Cell Biol (2012) 0.91
Regulation of NADPH oxidase 5 by protein kinase C isoforms. PLoS One (2014) 0.91
Nox enzymes in allergic airway inflammation. Biochim Biophys Acta (2011) 0.91
Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91
Radical decisions in cancer: redox control of cell growth and death. Cancers (Basel) (2012) 0.90
Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62
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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell (2005) 9.16
Molecular pathways of neurodegeneration in Parkinson's disease. Science (2003) 7.55
Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature (2002) 7.53
Myeloperoxidase: friend and foe. J Leukoc Biol (2005) 7.16
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Cell transformation by the superoxide-generating oxidase Mox1. Nature (1999) 6.23
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Inflammation in neurodegenerative disease--a double-edged sword. Neuron (2002) 4.95
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res (2005) 4.66
A direct role for dual oxidase in Drosophila gut immunity. Science (2005) 4.24
Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A (2000) 4.24
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene (2001) 3.97
Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95
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The neutrophil NADPH oxidase. Arch Biochem Biophys (2002) 3.71
Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol (2003) 3.63
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J (2003) 3.44
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol (2004) 3.35
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Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2006) 3.13
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci (2003) 3.13
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol (2002) 3.10
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem (2005) 2.98
NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal (2006) 2.95
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem (2003) 2.92
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci (2001) 2.89
A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem (2001) 2.80
Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation (2005) 2.79
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem (2000) 2.70
Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res (2002) 2.56
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem (2001) 2.56
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res (2003) 2.50
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol (2001) 2.40
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem (1999) 2.37
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest (2005) 2.34
Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal (2005) 2.32
Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes (2005) 2.31
A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation. Circ Res (2005) 2.29
Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci U S A (2002) 2.29
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem (2004) 2.28
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Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regul Integr Comp Physiol (2005) 2.25
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem (2004) 2.19
Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate (2005) 2.19
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci U S A (2001) 2.14
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res (2003) 2.13
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res (2004) 2.12
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NOX2 and NOX4 mediate proliferative response in endothelial cells. Antioxid Redox Signal (2006) 1.83
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gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation (2004) 1.77
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NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol (2003) 1.73
Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arterioscler Thromb Vasc Biol (2005) 1.72
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An NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am J Physiol Cell Physiol (2002) 1.55
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Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis (2006) 1.48
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cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem (2006) 1.42
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Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol (2004) 1.39