Published in FASEB J on June 03, 2003
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol (2004) 5.29
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med (2007) 3.48
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
Statin use reduces decline in lung function: VA Normative Aging Study. Am J Respir Crit Care Med (2007) 2.65
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol (2007) 2.29
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol (2009) 2.06
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res (2009) 1.97
Biological roles for the NOX family NADPH oxidases. J Biol Chem (2008) 1.96
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A (2005) 1.82
Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis (2011) 1.79
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal (2009) 1.71
Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans. Genetics (2007) 1.64
A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol (2012) 1.62
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog (2011) 1.59
Mechanisms of acid and base secretion by the airway epithelium. J Membr Biol (2006) 1.57
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med (2011) 1.56
NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med (2007) 1.50
Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice. J Clin Invest (2008) 1.49
Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome. Clin Gastroenterol Hepatol (2008) 1.39
Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. Am J Respir Cell Mol Biol (2006) 1.39
Mechanisms and function of DUOX in epithelia of the lung. Antioxid Redox Signal (2009) 1.38
Ce-Duox1/BLI-3 generates reactive oxygen species as a protective innate immune mechanism in Caenorhabditis elegans. Infect Immun (2009) 1.37
Dual oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 1.37
Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J (2008) 1.36
The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells. J Immunol (2008) 1.35
Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med (2008) 1.33
Salivary defense proteins: their network and role in innate and acquired oral immunity. Int J Mol Sci (2012) 1.32
Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals. Free Radic Biol Med (2010) 1.30
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem (2009) 1.29
NOX enzymes and pulmonary disease. Antioxid Redox Signal (2009) 1.29
NOX in liver fibrosis. Arch Biochem Biophys (2007) 1.29
Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. J Biol Chem (2009) 1.25
Gut pathology and responses to the microsporidium Nosema ceranae in the honey bee Apis mellifera. PLoS One (2012) 1.24
The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett (2006) 1.23
Gene expression in Porphyromonas gingivalis after contact with human epithelial cells. Infect Immun (2005) 1.22
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli. J Biol Chem (2009) 1.21
The Na+/I- symporter (NIS): mechanism and medical impact. Endocr Rev (2013) 1.21
Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol (2012) 1.18
Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med (2009) 1.17
Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal (2009) 1.16
Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues. Free Radic Res (2009) 1.16
Nox4: a hydrogen peroxide-generating oxygen sensor. Biochemistry (2014) 1.14
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
The role of hydrogen peroxide in environmental adaptation of oral microbial communities. Oxid Med Cell Longev (2012) 1.12
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci (2009) 1.11
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol (2008) 1.11
An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol (2014) 1.09
Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES). Dev Comp Immunol (2006) 1.08
Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett (2013) 1.06
Voltage-gated proton channels. Cell Mol Life Sci (2008) 1.06
The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. Proc Natl Acad Sci U S A (2009) 1.05
Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol (2010) 1.04
Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines. J Biol Chem (2011) 1.03
Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions. Front Cell Infect Microbiol (2014) 1.03
Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem (2008) 1.01
Nox enzymes in immune cells. Semin Immunopathol (2008) 1.01
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer (2010) 1.01
NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. Am J Physiol Heart Circ Physiol (2012) 0.99
Essential role of Duox in stabilization of Drosophila wing. J Biol Chem (2011) 0.99
The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. Toxicol Lett (2009) 0.98
The Na+/I- symporter mediates active iodide uptake in the intestine. Am J Physiol Cell Physiol (2008) 0.98
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS One (2013) 0.98
Mucin overproduction in chronic inflammatory lung disease. Can Respir J (2006) 0.97
Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. Am J Respir Cell Mol Biol (2011) 0.97
Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease. Pathogens (2013) 0.96
Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin. Immunol Res (2009) 0.96
Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon. J Gastroenterol (2009) 0.95
Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1. Free Radic Biol Med (2007) 0.95
Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid. Infect Immun (2012) 0.95
Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa. FEBS Lett (2010) 0.95
Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr (2011) 0.94
Genetic disorders coupled to ROS deficiency. Redox Biol (2015) 0.94
CaMKII is essential for the proasthmatic effects of oxidation. Sci Transl Med (2013) 0.93
Recent insights into the cell biology of thyroid angiofollicular units. Endocr Rev (2013) 0.93
Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4. Am J Physiol Cell Physiol (2012) 0.93
Differential gene expression in human conducting airway surface epithelia and submucosal glands. Am J Respir Cell Mol Biol (2008) 0.92
Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells. Thorax (2011) 0.92
Mice deficient in dual oxidase maturation factors are severely hypothyroid. Mol Endocrinol (2012) 0.92
IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines. J Immunol (2013) 0.91
Nox enzymes in allergic airway inflammation. Biochim Biophys Acta (2011) 0.91
Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis. Am J Respir Cell Mol Biol (2006) 0.91
Perinatal lamb model of respiratory syncytial virus (RSV) infection. Viruses (2012) 0.91
Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. Am J Respir Cell Mol Biol (2014) 0.90
Bacterial-modulated host immunity and stem cell activation for gut homeostasis. Genes Dev (2009) 0.90
Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS One (2012) 0.89
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. Am J Pathol (2008) 0.89
Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. PLoS Genet (2012) 0.89
Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs. PLoS One (2013) 0.89
Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis. Free Radic Biol Med (2011) 0.89
Nebulized thiocyanate improves lung infection outcomes in mice. Br J Pharmacol (2013) 0.88
NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res (2014) 0.87
A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector. J Biol Chem (2014) 0.87
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free Radic Biol Med (2011) 0.86
Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitric Oxide (2012) 0.86
Corneal avascularity is due to soluble VEGF receptor-1. Nature (2006) 4.77
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90
Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res (2008) 3.27
Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50
The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem (2004) 2.48
Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol Cell Biol (2006) 1.80
Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med (2006) 1.76
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem (2003) 1.70
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes. J Immunol (2003) 1.38
Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J (2008) 1.36
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest (2006) 1.36
The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells. J Immunol (2008) 1.35
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med (2012) 1.31
Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J Virol (2009) 1.27
Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol (2012) 1.18
A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol Biol Cell (2006) 1.14
Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis. BMC Gastroenterol (2010) 1.13
Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis. J Immunol (2008) 1.10
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife (2013) 1.06
Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. J Neurosci (2005) 1.06
The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal (2010) 1.06
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes. J Cell Biol (2003) 1.05
Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol (2010) 1.04
Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant. J Biol Chem (2004) 1.04
Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant (2007) 1.02
Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase. PLoS One (2013) 1.02
Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci (2004) 1.01
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase. J Biol Chem (2007) 1.01
Comment on "Failure of bone marrow cells to transdifferentiate into neural cells in vivo". Science (2003) 0.96
Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin. Immunol Res (2009) 0.96
Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa. FEBS Lett (2010) 0.95
Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta (2011) 0.94
Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. J Comp Neurol (2006) 0.92
Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation. J Immunol (2014) 0.91
The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA. PLoS One (2012) 0.91
Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration. ACS Nano (2013) 0.91
Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS One (2012) 0.89
Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis. Mol Cancer Ther (2013) 0.89
Radical generation and alterations of erythrocyte integrity as bioindicators of diagnostic or prognostic value in COPD? Antioxid Redox Signal (2008) 0.88
NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res (2014) 0.87
The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils. Cell Immunol (2002) 0.86
Two different pathways are involved in peroxynitrite-induced senescence and apoptosis of human erythrocytes. Free Radic Biol Med (2006) 0.86
Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase. Am J Respir Cell Mol Biol (2014) 0.85
Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P. Proc Natl Acad Sci U S A (2012) 0.84
Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain. J Biol Chem (2008) 0.82
Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b. Biochemistry (2007) 0.81
Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. J Cell Sci (2003) 0.81
The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene. Free Radic Biol Med (2013) 0.80
Clinicopathologic correlation of progressive fibrovascular proliferation associated with occult choroidal neovascularization in age-related macular degeneration. Arch Ophthalmol (2004) 0.80
Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. J Immunol (2004) 0.80
The K-562 cell model for analysis of neutrophil NADPH oxidase function. Methods Mol Biol (2007) 0.79
Toward a higher fidelity model of AMD. Adv Exp Med Biol (2008) 0.76