Published in Genes Dev on July 01, 2007
Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host Microbe (2008) 2.72
Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat (2009) 2.21
Deformation and failure of protein materials in physiologically extreme conditions and disease. Nat Mater (2009) 2.00
Intermediate filaments: primary determinants of cell architecture and plasticity. J Clin Invest (2009) 1.88
Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering. Tissue Eng Part B Rev (2010) 1.76
"IF-pathies": a broad spectrum of intermediate filament-associated diseases. J Clin Invest (2009) 1.55
Tracheal Basal cells: a facultative progenitor cell pool. Am J Pathol (2010) 1.53
Post-translational modifications of intermediate filament proteins: mechanisms and functions. Nat Rev Mol Cell Biol (2014) 1.50
Intermediate filaments take the heat as stress proteins. Trends Cell Biol (2010) 1.44
SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans. Dev Cell (2009) 1.43
Herpesvirus interactions with the host cytoskeleton. J Virol (2008) 1.43
Intermediate filament-like proteins in bacteria and a cytoskeletal function in Streptomyces. Mol Microbiol (2008) 1.37
The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol (2012) 1.36
Intermediate filaments: versatile building blocks of cell structure. Curr Opin Cell Biol (2008) 1.34
Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol (2009) 1.29
Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun (2014) 1.28
Functions of the intermediate filament cytoskeleton in the eye lens. J Clin Invest (2009) 1.26
Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol (2011) 1.25
Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle. J Clin Invest (2010) 1.21
Intermediate filaments exchange subunits along their length and elongate by end-to-end annealing. J Cell Biol (2009) 1.20
Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol (2012) 1.16
The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol (2011) 1.12
Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol (2009) 1.12
Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol Biol Cell (2010) 1.12
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat Struct Mol Biol (2012) 1.10
Keratin gene mutations in disorders of human skin and its appendages. Arch Biochem Biophys (2010) 1.10
Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia. Mol Biol Cell (2010) 1.10
Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell (2009) 1.04
Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta. Mol Biol Cell (2009) 1.02
A central role for vimentin in regulating repair function during healing of the lens epithelium. Mol Biol Cell (2014) 1.01
Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice. Exp Cell Res (2008) 1.01
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem (2010) 1.00
Intermediate filament cytoskeleton of the liver in health and disease. Histochem Cell Biol (2008) 0.99
Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology. Int J Exp Pathol (2009) 0.96
Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions. Am J Pathol (2008) 0.95
Cytoskeleton in mast cell signaling. Front Immunol (2012) 0.93
Isomin: a novel cytoplasmic intermediate filament protein from an arthropod species. BMC Biol (2011) 0.91
Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton. FASEB J (2008) 0.91
Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma. Cell Death Dis (2014) 0.90
O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18. J Biol Chem (2010) 0.90
Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination. Mol Cell Proteomics (2013) 0.90
Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. Mol Biol Cell (2012) 0.90
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89
Keratins in colorectal epithelial function and disease. Int J Exp Pathol (2012) 0.89
Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury. Am J Pathol (2008) 0.89
Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse. Nat Neurosci (2011) 0.89
Role of the cytoskeleton in flow (shear stress)-induced dilation and remodeling in resistance arteries. Med Biol Eng Comput (2008) 0.88
The molecular basis of human keratin disorders. Hum Genet (2009) 0.88
Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. Elife (2015) 0.87
Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem (2011) 0.87
IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments. J Neuroinflammation (2012) 0.87
The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. PLoS One (2012) 0.85
Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget (2015) 0.84
The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons. PLoS One (2011) 0.84
Identification of novel interaction between annexin A2 and keratin 17: evidence for reciprocal regulation. J Biol Chem (2012) 0.84
Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity. J Cell Sci (2014) 0.84
Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins. Cytoskeleton (Hoboken) (2015) 0.83
Topographical mapping of α- and β-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives. Proc Natl Acad Sci U S A (2015) 0.83
The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1. Development (2012) 0.82
Significance of novel bioinorganic anodic aluminum oxide nanoscaffolds for promoting cellular response. Nanotechnol Sci Appl (2011) 0.81
Computational characterization of 3' splice variants in the GFAP isoform family. PLoS One (2012) 0.81
Reorganization of the host cytoskeleton by the intracellular pathogen Chlamydia trachomatis. Commun Integr Biol (2008) 0.81
Multiple neurofilament subunits are present in lamprey CNS. Brain Res (2010) 0.80
The amount of keratins matters for stress protection of the colonic epithelium. PLoS One (2015) 0.80
Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression. Biomed Rep (2015) 0.80
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18. Nat Med (2015) 0.80
Deficiency of the intermediate filament synemin reduces bone mass in vivo. Am J Physiol Cell Physiol (2016) 0.80
Stressing the role of O-GlcNAc: linking cell survival to keratin modification. Nat Cell Biol (2010) 0.79
Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue. Exp Eye Res (2011) 0.79
Identification of phosphorylation-induced changes in vimentin intermediate filaments by site-directed spin labeling and electron paramagnetic resonance. Biochemistry (2008) 0.79
Skin Keratins. Methods Enzymol (2015) 0.78
Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation. Br J Dermatol (2014) 0.78
Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding. PLoS Negl Trop Dis (2016) 0.78
Herpesviruses and intermediate filaments: close encounters with the third type. Viruses (2011) 0.78
Keratins and protein synthesis: the plot thickens. J Cell Biol (2009) 0.78
Differential increases in the expression of intermediate filament proteins and concomitant morphological changes of transdifferentiating rat hepatic stellate cells observed in vitro. Acta Histochem Cytochem (2013) 0.78
Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells. J Ovarian Res (2016) 0.78
Asymmetric Distribution of GFAP in Glioma Multipotent Cells. PLoS One (2016) 0.77
Epithelial Intermediate Filaments: Guardians against Microbial Infection? Cells (2016) 0.77
Signaling mechanisms and disrupted cytoskeleton in the diphenyl ditelluride neurotoxicity. Oxid Med Cell Longev (2014) 0.77
Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion. Exp Cell Res (2015) 0.77
Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading. Biophys J (2012) 0.77
Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip. Biol Open (2013) 0.77
Engineering a biocompatible scaffold with either micrometre or nanometre scale surface topography for promoting protein adsorption and cellular response. Int J Biomater (2013) 0.77
Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.76
Effects of cobalt chloride on phenotypes of normal human saphenous vein smooth muscle cells. Int J Clin Exp Med (2014) 0.76
Interaction between Flavivirus and Cytoskeleton during Virus Replication. Biomed Res Int (2015) 0.76
Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS One (2016) 0.75
The tail domain is essential but the head domain dispensable for C. elegans intermediate filament IFA-2 function. PLoS One (2015) 0.75
Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades. Elife (2016) 0.75
IRAP(+) endosomes restrict TLR9 activation and signaling. Nat Immunol (2017) 0.75
ngs (notochord granular surface) gene encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. J Biol Chem (2012) 0.75
A novel function for the MAP kinase SMA-5 in intestinal tube stability. Mol Biol Cell (2016) 0.75
The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell (2016) 0.75
Role of keratin 24 in human epidermal keratinocytes. PLoS One (2017) 0.75
Intermediate filament proteins of digestive organs: Physiology and pathophysiology. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature (2006) 3.28
New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27
Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nat Neurosci (2007) 3.12
Intermediate filament proteins and their associated diseases. N Engl J Med (2004) 2.84
MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev (2004) 2.07
Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol (2012) 1.72
Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet (2010) 1.63
Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair. J Cell Biol (2003) 1.58
Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. J Neurosci (2008) 1.53
Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes Dev (2002) 1.47
Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A (2005) 1.41
The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol (2012) 1.36
Emerging role for the cytoskeleton as an organizer and regulator of translation. Nat Rev Mol Cell Biol (2010) 1.35
Keratin function in skin epithelia: a broadening palette with surprising shades. Curr Opin Cell Biol (2006) 1.34
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. Proc Natl Acad Sci U S A (2007) 1.34
Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev (2006) 1.26
The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development (2004) 1.24
Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. J Invest Dermatol (2002) 1.19
Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments. Mol Biol Cell (2002) 1.17
Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A (2013) 1.16
Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol (2005) 1.14
Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol (2009) 1.12
The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities. J Struct Biol (2003) 1.11
Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles. J Invest Dermatol (2003) 1.11
An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization. J Invest Dermatol (2002) 1.11
Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells. Nat Struct Mol Biol (2007) 1.11
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat Struct Mol Biol (2012) 1.10
Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia. Mol Biol Cell (2010) 1.10
A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability. J Cell Biol (2005) 1.09
Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol (2013) 1.07
Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev Dyn (2003) 1.07
Intermediate filaments and tissue repair. Exp Cell Res (2004) 1.04
A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair. J Cell Biol (2012) 1.01
Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles. J Invest Dermatol (2006) 1.00
A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. J Invest Dermatol (2004) 1.00
Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice. Mol Cell Biol (2005) 0.99
Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile. FASEB J (2007) 0.96
Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions. Am J Pathol (2008) 0.95
Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis. J Invest Dermatol (2004) 0.92
Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest (2014) 0.91
Skin: an ideal model system to study keratin genes and proteins. Methods Cell Biol (2004) 0.89
Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem (2011) 0.87
Defining the properties of the nonhelical tail domain in type II keratin 5: insight from a bullous disease-causing mutation. Mol Biol Cell (2005) 0.86
Identification of novel interaction between annexin A2 and keratin 17: evidence for reciprocal regulation. J Biol Chem (2012) 0.84
Keratin intracellular concentration revisited: implications for keratin function in surface epithelia. J Invest Dermatol (2012) 0.82
Modeling the self-organization property of keratin intermediate filaments. Biophys J (2010) 0.81
Mouse models of alopecia: identifying structural genes that are baldly needed. Trends Mol Med (2003) 0.80
Stressing the role of O-GlcNAc: linking cell survival to keratin modification. Nat Cell Biol (2010) 0.79
A new fold on an old story: attachment of intermediate filaments to desmosomes. Nat Struct Biol (2002) 0.79
Preview. SKPing a hurdle: Sox2 and adult dermal stem cells. Cell Stem Cell (2009) 0.79
Keratins and protein synthesis: the plot thickens. J Cell Biol (2009) 0.78
Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes. J Clin Invest (2016) 0.78
Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading. Biophys J (2012) 0.77
Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin. J Cell Sci (2012) 0.76