Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

PubWeight™: 1.77‹?› | Rank: Top 3%

🔗 View Article (PMID 17610416)

Published in Tissue Antigens on August 01, 2007

Authors

G Thomson1, A M Valdes, J A Noble, I Kockum, M N Grote, J Najman, H A Erlich, F Cucca, A Pugliese, A Steenkiste, J S Dorman, S Caillat-Zucman, R Hermann, J Ilonen, A P Lambert, P J Bingley, K M Gillespie, A Lernmark, C B Sanjeevi, K S Rønningen, D E Undlien, E Thorsby, A Petrone, R Buzzetti, B P C Koeleman, B O Roep, G Saruhan-Direskeneli, F A Uyar, H Günoz, C Gorodezky, C Alaez, B O Boehm, W Mlynarski, H Ikegami, M Berrino, M E Fasano, E Dametto, S Israel, C Brautbar, A Santiago-Cortes, T Frazer de Llado, J-X She, T L Bugawan, J I Rotter, L Raffel, A Zeidler, F Leyva-Cobian, B R Hawkins, S H Chan, L Castano, F Pociot, J Nerup

Author Affiliations

1: Department of Integrative Biology, University of California, Berkeley, CA 94720-3140, USA. glenys@berkeley.edu

Articles citing this

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94

The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes (2011) 2.44

Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum (2010) 1.99

Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66

Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Diabetologia (2008) 1.61

Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes (2010) 1.48

Genetics of the HLA region in the prediction of type 1 diabetes. Curr Diab Rep (2011) 1.30

Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis. Hum Mol Genet (2009) 1.10

The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun (2015) 1.04

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes (2008) 1.01

Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West. Rev Diabet Stud (2008) 0.98

Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab (2009) 0.98

Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. Hum Immunol (2008) 0.94

Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens (2011) 0.94

Can Roux-en-Y gastric bypass provide a lifelong solution for diabetes mellitus? Can J Surg (2009) 0.93

Evidence for more than one Parkinson's disease-associated variant within the HLA region. PLoS One (2011) 0.92

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nat Genet (2015) 0.91

Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism. J Hum Genet (2015) 0.91

Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis. Pac Symp Biocomput (2010) 0.91

Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA. J Clin Invest (2014) 0.90

Analytical methods for disease association studies with immunogenetic data. Methods Mol Biol (2012) 0.86

Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes. Genes Immun (2010) 0.86

Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects. Immunogenetics (2009) 0.85

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development. PLoS One (2014) 0.85

HLA-associated phenotypes in youth with autoimmune diabetes. Pediatr Diabetes (2012) 0.84

Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype. Diabetes Obes Metab (2009) 0.81

Conditional asymmetric linkage disequilibrium (ALD): extending the biallelic r2 measure. Genetics (2014) 0.80

Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual β-cell function 1 year after diagnosis of type 1 diabetes. PLoS One (2013) 0.78

The association between the HLA-G 14-bp insertion/deletion polymorphism and type 1 diabetes. Genes Immun (2015) 0.77

Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes. Diabetes (2016) 0.77

MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes Obes Metab (2009) 0.77

Prevalence of Autoantibodies and HLA DR, DQ in Type 1 Diabetes Mellitus. J Clin Diagn Res (2016) 0.76

Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy. Diabetol Metab Syndr (2016) 0.76

HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese. J Diabetes Investig (2016) 0.76

Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention. J Diabetes Investig (2011) 0.75

Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach. PLoS One (2013) 0.75

The influence of population stratification on genetic markers associated with type 1 diabetes. Sci Rep (2017) 0.75

ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese. Meta Gene (2016) 0.75

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype. Genes (Basel) (2017) 0.75

Early prediction of autoimmune (type 1) diabetes. Diabetologia (2017) 0.75

Articles by these authors

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77

Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08

Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science (1986) 19.54

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc Natl Acad Sci U S A (1988) 18.72

Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature (1986) 17.77

Mutational processes of simple-sequence repeat loci in human populations. Proc Natl Acad Sci U S A (1994) 11.84

Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature (1988) 10.84

Length mutations in human mitochondrial DNA: direct sequencing of enzymatically amplified DNA. Nucleic Acids Res (1987) 10.38

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46

DNA typing from single hairs. Nature (1988) 9.32

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76

Characterization of beta-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA. Nature (1987) 8.58

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med (1992) 8.27

Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A (1989) 7.79

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05

The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature (1991) 6.17

Which guidelines can we trust?: Assessing strength of evidence behind recommendations for clinical practice. West J Med (2001) 6.10

Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet (1993) 4.49

HL-A antigens and diabetes mellitus. Lancet (1974) 4.42

Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood (1998) 4.41

Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. Diabetologia (2003) 4.33

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med (1989) 4.30

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci U S A (1988) 4.19

Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med (1986) 4.18

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides. Biochem Biophys Res Commun (1987) 4.05

The polymerase chain reaction. Trends Genet (1989) 3.95

The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet (2000) 3.92

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet (1995) 3.87

Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med (2001) 3.85

The Pittsburgh insulin-dependent diabetes mellitus (IDDM) morbidity and mortality study. Mortality results. Diabetes (1984) 3.66

Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics (1990) 3.53

Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J Immunol (1983) 3.53

Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY) JAMA (1996) 3.52

Rapid prenatal diagnosis of sickle cell anemia by a new method of DNA analysis. N Engl J Med (1987) 3.44

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet (1996) 3.37

Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. The Bart's-Oxford Study Group. BMJ (1997) 3.33

A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30

Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature (1990) 3.30

The British Diabetic Association Cohort Study, II: cause-specific mortality in patients with insulin-treated diabetes mellitus. Diabet Med (1999) 3.26

Addison's disease--clinical studies. A report fo 108 cases. Acta Endocrinol (Copenh) (1974) 3.24

Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia (1996) 3.23

Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. J Immunol (1992) 3.15

General-practitioner hospital beds: a review. Br Med J (1971) 3.14

Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med (1993) 3.10

Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup. Gastroenterology (1996) 3.08

Prevalence of complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications Study II. Diabetes (1990) 3.07

Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. A study in relatives of patients with pernicious anemia. Gastroenterology (1982) 3.05

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest (1992) 2.99

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet (1995) 2.93

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet (1996) 2.90

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet (2004) 2.90

A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med (1992) 2.86

Cytokine gene polymorphism in human disease: on-line databases. Genes Immun (1999) 2.86

Gestational diabetes mellitus in India. J Assoc Physicians India (2004) 2.86

Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase. Diabetologia (2012) 2.85

A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet (1998) 2.85

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science (1986) 2.83

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature (1994) 2.82

Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia (1999) 2.81

Family history: a comprehensive genetic risk assessment method for the chronic conditions of adulthood. Am J Med Genet (1997) 2.79

New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J Immunol (1999) 2.76

HLA class II allelic variation and susceptibility to pemphigus vulgaris. Proc Natl Acad Sci U S A (1988) 2.72

HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology (1993) 2.72

Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut (2000) 2.71

HLA-D restriction of the macrophage-dependent response of immune human T lymphocytes to PPD in vitro: inhibition by anti-HLA-DR antisera. Scand J Immunol (1978) 2.70

The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia (1974) 2.69

High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens (2009) 2.64

Diagnosis of sickle cell anemia and beta-thalassemia with enzymatically amplified DNA and nonradioactive allele-specific oligonucleotide probes. N Engl J Med (1988) 2.64

Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nat Genet (1992) 2.63

The selection of control subjects for case/control analysis of susceptibility to type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1993) 2.63

Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann Intern Med (1979) 2.61

Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature (1982) 2.58

HLA-DR-like antigens in the epithelium of the human small intestine. Scand J Immunol (1980) 2.58

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J Clin Invest (1997) 2.57

Population variation of human mtDNA control region sequences detected by enzymatic amplification and sequence-specific oligonucleotide probes. Am J Hum Genet (1991) 2.56

Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology (1989) 2.55

Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia (2008) 2.51

Preferential PCR amplification of alleles: mechanisms and solutions. PCR Methods Appl (1992) 2.47

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia (2012) 2.41

Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J Immunol (1992) 2.39

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. Diabetes (1998) 2.38

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Mortality trends in type 1 diabetes. The Allegheny County (Pennsylvania) Registry 1965-1999. Diabetes Care (2001) 2.36

Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut (1993) 2.35