Published in Nucleic Acids Res on January 26, 1987
A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res (1988) 26.70
Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acids Res (1989) 19.85
Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc Natl Acad Sci U S A (1988) 18.72
Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. Proc Natl Acad Sci U S A (1989) 12.95
Extensive mitochondrial diversity within a single Amerindian tribe. Proc Natl Acad Sci U S A (1991) 9.35
Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support. Nucleic Acids Res (1989) 9.04
Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet (1993) 6.81
Fidelity of DNA polymerases in DNA amplification. Proc Natl Acad Sci U S A (1989) 5.56
Ancient DNA: extraction, characterization, molecular cloning, and enzymatic amplification. Proc Natl Acad Sci U S A (1989) 5.50
Geographic variation in human mitochondrial DNA from Papua New Guinea. Genetics (1990) 5.44
Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages. Am J Hum Genet (1990) 5.17
Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations. Genetics (1992) 4.78
mtDNA and the origin of Caucasians: identification of ancient Caucasian-specific haplogroups, one of which is prone to a recurrent somatic duplication in the D-loop region. Am J Hum Genet (1994) 4.47
mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans. Am J Hum Genet (1993) 4.46
Direct sequencing of enzymatically amplified human genomic DNA. Proc Natl Acad Sci U S A (1988) 4.41
Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups. Am J Hum Genet (1995) 4.30
Construction of mutant and chimeric genes using the polymerase chain reaction. Nucleic Acids Res (1989) 4.19
mtDNA sequences suggest a recent evolutionary divergence for Beringian and northern North American populations. Am J Hum Genet (1993) 4.18
Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations. Genetics (1992) 4.12
Optimal conditions for directly sequencing double-stranded PCR products with sequenase. Nucleic Acids Res (1990) 3.90
Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich. Am J Hum Genet (1988) 3.50
Mitochondrial DNA sequences from a 7000-year old brain. Nucleic Acids Res (1988) 3.38
1994 William Allan Award Address. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. Am J Hum Genet (1995) 3.22
An Asian-specific 9-bp deletion of mitochondrial DNA is frequently found in Polynesians. Am J Hum Genet (1989) 3.13
The origins of the Polynesians: an interpretation from mitochondrial lineage analysis. Am J Hum Genet (1995) 2.98
mtDNA control-region sequence variation suggests multiple independent origins of an "Asian-specific" 9-bp deletion in sub-Saharan Africans. Am J Hum Genet (1996) 2.79
Polynesian genetic affinities with Southeast Asian populations as identified by mtDNA analysis. Am J Hum Genet (1995) 2.74
mtDNA and Y-chromosome polymorphisms in four Native American populations from southern Mexico. Am J Hum Genet (1994) 2.68
Founder mitochondrial haplotypes in Amerindian populations. Am J Hum Genet (1994) 2.56
Nucleic acid amplification in vitro: detection of sequences with low copy numbers and application to diagnosis of human immunodeficiency virus type 1 infection. Clin Microbiol Rev (1989) 2.43
Direct sequencing of polymerase chain reaction amplified DNA fragments through the incorporation of deoxynucleoside alpha-thiotriphosphates. Nucleic Acids Res (1988) 2.28
Incomplete primer extension during in vitro DNA amplification catalyzed by Taq polymerase; exploitation for DNA sequencing. Nucleic Acids Res (1989) 2.21
Testing migration patterns and estimating founding population size in Polynesia by using human mtDNA sequences. Proc Natl Acad Sci U S A (1998) 2.04
mtDNA analysis of a prehistoric Oneota population: implications for the peopling of the New World. Am J Hum Genet (1998) 2.01
Compilation of human mtDNA control region sequences. Nucleic Acids Res (1998) 2.00
Enzymatic amplification of human cytomegalovirus sequences by polymerase chain reaction. J Clin Microbiol (1989) 1.81
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. Am J Hum Genet (1992) 1.77
Amplification of bacterial genomic DNA by the polymerase chain reaction and direct sequencing after asymmetric amplification: application to the study of periplasmic permeases. J Bacteriol (1989) 1.77
The efficiency of multilocus DNA fingerprint probes for individualization and establishment of family relationships, determined from extensive casework. Am J Hum Genet (1991) 1.76
Recent origin and cultural reversion of a hunter-gatherer group. PLoS Biol (2005) 1.75
Conformational mutation in human mtDNA detected by direct sequencing of enzymatically amplified DNA. Nucleic Acids Res (1988) 1.74
COII/tRNA(Lys) intergenic 9-bp deletion and other mtDNA markers clearly reveal that the Tharus (southern Nepal) have Oriental affinities. Am J Hum Genet (1993) 1.66
Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants. J Virol (1996) 1.55
A novel missense mutation in the factor VIII gene identified by analysis of amplified hemophilia DNA sequences. Nucleic Acids Res (1987) 1.50
Segregation of mitochondrial genomes in a heteroplasmic lineage with Leber hereditary optic neuroretinopathy. Am J Hum Genet (1990) 1.46
The genetic relationship between the Finns and the Finnish Saami (Lapps): analysis of nuclear DNA and mtDNA. Am J Hum Genet (1996) 1.46
Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis. Am J Hum Genet (1990) 1.40
Molecular instability in the COII-tRNA(Lys) intergenic region of the human mitochondrial genome: multiple origins of the 9-bp deletion and heteroplasmy for expanded repeats. Philos Trans R Soc Lond B Biol Sci (1998) 1.30
Phylotyping and functional analysis of two ancient human microbiomes. PLoS One (2008) 1.29
Evidence for mitochondrial DNA recombination in a human population of island Melanesia. Proc Biol Sci (1999) 1.21
Multiple independent origins of the COII/tRNA(Lys) intergenic 9-bp mtDNA deletion in aboriginal Australians. Am J Hum Genet (1996) 1.14
Large sequence divergence among mitochondrial DNA genotypes within populations of eastern African black-backed jackals. Proc Natl Acad Sci U S A (1990) 1.13
mtDNA history of the Cayapa Amerinds of Ecuador: detection of additional founding lineages for the Native American populations. Am J Hum Genet (1999) 1.12
Mitochondrial control-region sequence variation in aboriginal Australians. Am J Hum Genet (1998) 1.08
A factor IX mutation, verified by direct genomic sequencing, causes haemophilia B by a novel mechanism. EMBO J (1988) 1.06
Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markers. Philos Trans R Soc Lond B Biol Sci (1999) 1.04
Molecular basis of lactase levels in adult humans. J Clin Invest (1992) 1.03
About the "Asian"-specific 9-bp deletion of mtDNA.... Am J Hum Genet (1995) 1.01
Direct uptake and degradation of DNA by lysosomes. Autophagy (2013) 0.96
Mitochondrial DNA polymorphisms in Carib people of Belize. Proc Biol Sci (1997) 0.90
Sequence analysis of mitochondrial DNA in a new maternally inherited encephalomyopathy. J Neurol (1995) 0.87
Major histocompatibility complex-linked diabetogenic gene of the nonobese diabetic mouse. Analysis of genomic DNA amplified by the polymerase chain reaction. J Clin Invest (1990) 0.86
Identification of the pheS5 mutation, which causes thermosensitivity of Escherichia coli mutant NP37. J Bacteriol (1992) 0.81
Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population. Saudi J Biol Sci (2014) 0.79
The mitochondrial DNA 9-bp deletion polymorphism is a risk factor for hepatocellular carcinoma in the Chinese population. Genet Test Mol Biomarkers (2012) 0.78
Screening ancient tuberculosis with qPCR: challenges and opportunities. Philos Trans R Soc Lond B Biol Sci (2015) 0.78
Reply to Merriwether et al. Am J Hum Genet (1995) 0.75
Genetic testing of identity and relationship. Am J Hum Genet (1989) 0.75
Characterization of single base substitutions in edited apolipoprotein B transcripts. Nucleic Acids Res (1989) 0.75
Polymerase chain reaction fingerprints. Nucleic Acids Res (1987) 0.75
SCID mice containing muscle with human mitochondrial DNA mutations. An animal model for mitochondrial DNA defects. J Clin Invest (1998) 0.75
Molecular biology in medicine. Postgrad Med J (1992) 0.75
The 9-bp deletion in region V of mtDNA: a risk factor of hearing loss and encephalomyopathy in Caucasian populations? Neurol Sci (2013) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. Gene (1982) 59.01
Sequence and organization of the human mitochondrial genome. Nature (1981) 57.39
The use of thin acrylamide gels for DNA sequencing. FEBS Lett (1978) 40.52
Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science (1986) 19.54
Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature (1986) 17.77
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A (1980) 9.48
A set of synthetic oligodeoxyribonucleotide primers for DNA sequencing in the plasmid vector pBR322. Gene (1981) 5.06
Length mutations in human mitochondrial DNA. Genetics (1983) 4.81
Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA. Gene (1983) 4.47
Polymorphic sites and the mechanism of evolution in human mitochondrial DNA. Genetics (1984) 4.00
Mitochondrial DNA polymorphism in Japanese. II. Analysis with restriction enzymes of four or five base pair recognition. Hum Genet (1986) 3.93
Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue. Cell (1984) 2.95
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28
Rate of sequence divergence estimated from restriction maps of mitochondrial DNAs from Papua New Guinea. Cold Spring Harb Symp Quant Biol (1986) 2.13
Accepted mutations in a gene family: evolutionary diversification of duplicated DNA. J Mol Evol (1982) 2.03
Rat mitochondrial DNA polymorphism: sequence analysis of a hypervariable site for insertions/deletions. Nucleic Acids Res (1983) 1.90
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A (1979) 22.76
Mitochondrial DNA and human evolution. Nature (1987) 22.33
Evolution at two levels in humans and chimpanzees. Science (1975) 21.07
Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science (1986) 19.54
Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc Natl Acad Sci U S A (1988) 18.72
African populations and the evolution of human mitochondrial DNA. Science (1991) 18.08
Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature (1986) 17.77
Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. Proc Natl Acad Sci U S A (1989) 12.95
Biochemical evolution. Annu Rev Biochem (1977) 12.74
Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol (1982) 11.47
Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature (1988) 10.84
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell (1988) 10.29
Evolution in bacteria: evidence for a universal substitution rate in cellular genomes. J Mol Evol (1987) 9.84
DNA typing from single hairs. Nature (1988) 9.32
Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A (1992) 9.15
Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med (1988) 9.10
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Characterization of beta-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA. Nature (1987) 8.58
Neandertal DNA sequences and the origin of modern humans. Cell (1997) 8.45
Branching pattern in the evolutionary tree for human mitochondrial DNA. Proc Natl Acad Sci U S A (1991) 8.23
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science (2001) 7.87
Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A (1989) 7.79
Mitochondrial DNA sequences in single hairs from a southern African population. Proc Natl Acad Sci U S A (1989) 6.92
A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res (1989) 6.78
A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human delta and beta globin genes. Nucleic Acids Res (1981) 6.70
DNA damage promotes jumping between templates during enzymatic amplification. J Biol Chem (1990) 6.59
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06
Evolution of the cytochrome b gene of mammals. J Mol Evol (1991) 5.71
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Geographic variation in human mitochondrial DNA from Papua New Guinea. Genetics (1990) 5.44
Paternal inheritance of mitochondrial DNA in mice. Nature (1991) 5.38
Heterogeneity of the ribosomal genes in mice and men. Cell (1977) 5.36
Monophyletic origin of Lake Victoria cichlid fishes suggested by mitochondrial DNA sequences. Nature (1990) 5.34
Length mutations in human mitochondrial DNA. Genetics (1983) 4.81
Polymerase chain reaction reveals cloning artefacts. Nature (1988) 4.76
5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains. Cell (1980) 4.62
Mismatch distributions of mtDNA reveal recent human population expansions. Hum Biol (1994) 4.39
Rapid duplication and loss of genes coding for the alpha chains of hemoglobin. Proc Natl Acad Sci U S A (1980) 4.33
Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci U S A (1988) 4.19
Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides. Biochem Biophys Res Commun (1987) 4.05
Polymorphic sites and the mechanism of evolution in human mitochondrial DNA. Genetics (1984) 4.00
Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolution. J Mol Evol (1984) 3.98
The polymerase chain reaction. Trends Genet (1989) 3.95
Evolutionary tree for apes and humans based on cleavage maps of mitochondrial DNA. Proc Natl Acad Sci U S A (1981) 3.93
Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes. Proc Natl Acad Sci U S A (1980) 3.92
A molecular time scale for human evolution. Proc Natl Acad Sci U S A (1969) 3.89
DNA sequences from the quagga, an extinct member of the horse family. Nature (1984) 3.86
Adaptive evolution in the stomach lysozymes of foregut fermenters. Nature (1987) 3.78
Immunological time scale for hominid evolution. Science (1967) 3.76
Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCR. Nucleic Acids Res (1992) 3.74
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron (1998) 3.72
Two types of molecular evolution. Evidence from studies of interspecific hybridization. Proc Natl Acad Sci U S A (1974) 3.69
Characteristics and frequency of germline mutations at microsatellite loci from the human Y chromosome, as revealed by direct observation in father/son pairs. Am J Hum Genet (2000) 3.59
Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics (1990) 3.53
Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J Immunol (1983) 3.53
Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY) JAMA (1996) 3.52
Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis (1988) 3.52
Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci U S A (1989) 3.50
Rapid prenatal diagnosis of sickle cell anemia by a new method of DNA analysis. N Engl J Med (1987) 3.44
Ancient DNA and the polymerase chain reaction. The emerging field of molecular archaeology. J Biol Chem (1989) 3.44
Mitochondrial DNA sequences from a 7000-year old brain. Nucleic Acids Res (1988) 3.38
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30
Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature (1990) 3.30
Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia (1996) 3.23
Toward a more accurate time scale for the human mitochondrial DNA tree. J Mol Evol (1993) 3.23
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
Human nucleolus organizers on nonhomologous chromosomes can share the same ribosomal gene variants. Proc Natl Acad Sci U S A (1981) 3.21
Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res (1990) 3.13
Albumin phylogeny for clawed frogs (Xenopus). Science (1977) 3.12
Evolutionary history of the COII/tRNALys intergenic 9 base pair deletion in human mitochondrial DNAs from the Pacific. Mol Biol Evol (1995) 3.10
African origin of human-specific polymorphic Alu insertions. Proc Natl Acad Sci U S A (1994) 3.09
Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99
The importance of gene rearrangement in evolution: evidence from studies on rates of chromosomal, protein, and anatomical evolution. Proc Natl Acad Sci U S A (1974) 2.97
Nonneutral mitochondrial DNA variation in humans and chimpanzees. Genetics (1996) 2.93
Mitochondrial DNA evolution in mice. Genetics (1983) 2.91
Flow of mitochondrial DNA across a species boundary. Proc Natl Acad Sci U S A (1983) 2.91
The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet (1996) 2.90
The dependence of immunological cross-reactivity upon sequence resemblance among lysozymes. II. Comparison of precipitin and micro-complement fixation results. J Biol Chem (1971) 2.90
Tempo and mode of sequence evolution in mitochondrial DNA of Hawaiian Drosophila. J Mol Evol (1987) 2.88
The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis. Mol Cell Biol (1986) 2.86
Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female. Nature (1982) 2.85
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function. Genes Dev (1997) 2.84
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A (1992) 2.83
mtDNA control-region sequence variation suggests multiple independent origins of an "Asian-specific" 9-bp deletion in sub-Saharan Africans. Am J Hum Genet (1996) 2.79
Polynesian genetic affinities with Southeast Asian populations as identified by mtDNA analysis. Am J Hum Genet (1995) 2.74
HLA class II allelic variation and susceptibility to pemphigus vulgaris. Proc Natl Acad Sci U S A (1988) 2.72
Distribution of ribosomal gene length variants among mouse chromosomes. Proc Natl Acad Sci U S A (1982) 2.66
Enzyme evolution in the Enterobacteriaceae. J Bacteriol (1972) 2.65
High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens (2009) 2.64