Published in Metab Eng on May 23, 2007
Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL. Biotechnol J (2014) 1.38
Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Syst Biol (2010) 1.36
The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. Oncol Rep (2009) 1.09
Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int J Oncol (2013) 0.95
A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells. Biotechnol Bioeng (2011) 0.93
The expanding world of tissue engineering: the building blocks and new applications of tissue engineered constructs. IEEE Rev Biomed Eng (2012) 0.92
Metabolic and kinetic analyses of influenza production in perfusion HEK293 cell culture. BMC Biotechnol (2011) 0.89
Rotenone enhances the antifungal properties of staurosporine. Eukaryot Cell (2010) 0.86
Engineering cells to improve protein expression. Curr Opin Struct Biol (2014) 0.86
Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival. J Bioenerg Biomembr (2014) 0.85
Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. RNA Biol (2013) 0.85
CHO microRNA engineering is growing up: recent successes and future challenges. Biotechnol Adv (2013) 0.84
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma. Dig Dis Sci (2014) 0.83
Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab Eng (2013) 0.83
Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation. Protein Eng Des Sel (2011) 0.82
ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol (2015) 0.81
Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat sertoli cells. ISRN Urol (2013) 0.80
Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885. Nutrients (2014) 0.79
Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila. Genes Cancer (2015) 0.76
Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells. PLoS One (2016) 0.75
Improvements in protein production in mammalian cells from targeted metabolic engineering. Curr Opin Syst Biol (2017) 0.75
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol (2011) 2.87
A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution. Curr Opin Biotechnol (2008) 1.69
A mathematical model of N-linked glycosylation. Biotechnol Bioeng (2005) 1.42
Controlling N-linked glycan site occupancy. Biochim Biophys Acta (2005) 1.42
Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL. Biotechnol J (2014) 1.38
Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nat Biotechnol (2013) 1.36
Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines. Glycoconj J (2004) 1.27
Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life. Biochim Biophys Acta (2009) 1.17
Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expr Purif (2009) 1.09
Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org. Biotechnol Bioeng (2011) 1.08
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool. Biotechnol Bioeng (2014) 1.04
A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology (2009) 1.01
The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology. Curr Opin Biotechnol (2013) 0.98
Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends Biotechnol (2004) 0.97
The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana. Appl Microbiol Biotechnol (2011) 0.97
Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them. Biochemistry (2003) 0.96
Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells. Biotechnol Bioeng (2005) 0.95
False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five insect cells: effect of glycosylation. J Immunol Methods (2007) 0.93
Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions. Biotechnol Bioeng (2004) 0.93
An improved colony PCR procedure for genetic screening of Chlorella and related microalgae. Biotechnol Lett (2011) 0.91
Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology (2002) 0.91
Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnol Bioeng (2006) 0.91
Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins. Biotechnol Bioeng (2011) 0.90
Humanization of lepidopteran insect-cell-produced glycoproteins. Acc Chem Res (2003) 0.90
Cellular trafficking and photochemical internalization of cell penetrating peptide linked cargo proteins: a dual fluorescent labeling study. Bioconjug Chem (2011) 0.89
Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells. Biotechnol Bioeng (2007) 0.89
Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants. Biotechnol Bioeng (2002) 0.89
Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L). Biotechnol Bioeng (2008) 0.89
GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. J Proteome Res (2011) 0.88
Engineering intracellular CMP-sialic acid metabolism into insect cells and methods to enhance its generation. Biochemistry (2005) 0.87
A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures. Metab Eng (2003) 0.86
Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival. J Bioenerg Biomembr (2014) 0.85
Integration of the transcriptome and glycome for identification of glycan cell signatures. PLoS Comput Biol (2013) 0.85
Purification, characterization, and cloning of a Spodoptera frugiperda Sf9 beta-N-acetylhexosaminidase that hydrolyzes terminal N-acetylglucosamine on the N-glycan core. J Biol Chem (2006) 0.85
Physiological evaluation of a new Chlorella sorokiniana isolate for its biomass production and lipid accumulation in photoautotrophic and heterotrophic cultures. Biotechnol Bioeng (2012) 0.84
Study of caspase inhibitors for limiting death in mammalian cell culture. Biotechnol Bioeng (2003) 0.84
Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. J Biol Chem (2006) 0.84
Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells. Biotechnol Bioeng (2005) 0.84
Chemical caspase inhibitors enhance cell culture viabilities and protein titer. Biotechnol Prog (2007) 0.84
Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells. Biotechnol Prog (2009) 0.83
Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture. Biotechnol Bioeng (2009) 0.83
Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian [beta]-1,4-galactosyltransferase and [beta]-1,2-N-acetylglucosaminyltransferase II. Glycobiology (2002) 0.83
Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation. Protein Eng Des Sel (2011) 0.82
E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells. J Biotechnol (2008) 0.81
Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture. Biotechnol Bioeng (2007) 0.81
Transient and stable expression of the neurotensin receptor NTS1: a comparison of the baculovirus-insect cell and the T-REx-293 expression systems. PLoS One (2013) 0.81
Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase. Biochem Biophys Res Commun (2005) 0.80
Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells Dev (2010) 0.80
N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system. Glycobiology (2003) 0.79
An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering. Virus Res (2009) 0.79
Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines. Biotechnol Prog (2010) 0.79
Protein and genome evolution in Mammalian cells for biotechnology applications. Mol Biotechnol (2009) 0.79
Coupling enrichment methods with proteomics for understanding and treating disease. Proteomics Clin Appl (2015) 0.78
An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: application to monitor glycan modulation by medium conditions. Glycoconj J (2009) 0.78
Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones. Histochem Cell Biol (2011) 0.78
Bioprospecting of microalgae for integrated biomass production and phytoremediation of unsterilized wastewater and anaerobic digestion centrate. Appl Microbiol Biotechnol (2015) 0.78
Feast or famine: autophagy control and engineering in eukaryotic cell culture. Curr Opin Biotechnol (2008) 0.78
Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures. Biotechnol Bioeng (2007) 0.78
The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Appl Microbiol Biotechnol (2014) 0.77
DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons. ACS Chem Biol (2011) 0.77
Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines. Biotechnol Appl Biochem (2012) 0.76
Achieving high throughput sequencing of a cDNA library utilizing an alternative protocol for the bench top next-generation sequencing system. J Microbiol Methods (2012) 0.76
Tat-tetanus toxin fragment C: a novel protein delivery vector and its use with photochemical internalization. J Drug Target (2013) 0.76
Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells. Biochem Biophys Res Commun (2010) 0.75
Strategies for Engineering Protein N-Glycosylation Pathways in Mammalian Cells. Methods Mol Biol (2015) 0.75
Mineral and non-carbon nutrient utilization and recovery during sequential phototrophic-heterotrophic growth of lipid-rich algae. Appl Microbiol Biotechnol (2014) 0.75
Metabolic engineering II. Eukaryotic systems. Biotechnol Bioeng (2002) 0.75
Engineering Sialic Acid Synthesis Ability in Insect Cells. Methods Mol Biol (2015) 0.75
Controlling apoptosis to optimize yields of proteins from mammalian cells. Methods Mol Biol (2012) 0.75