Published in Nature on July 05, 2007
Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature (2011) 4.10
MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol (2008) 3.24
Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study. Biophys J (2008) 1.38
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem (2009) 1.21
An evolutionary history of P2X receptors. Purinergic Signal (2008) 1.11
The nuclear envelope proteome differs notably between tissues. Nucleus (2012) 1.05
ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel. Pflugers Arch (2009) 1.04
Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations. Mol Cell Proteomics (2010) 1.02
Minor sarcoplasmic reticulum membrane components that modulate excitation-contraction coupling in striated muscles. J Physiol (2009) 1.01
Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation. Development (2009) 1.00
Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1. PLoS One (2011) 0.99
Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel. Biophys J (2010) 0.99
Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. J Biol Chem (2008) 0.97
Tissue specificity in the nuclear envelope supports its functional complexity. Nucleus (2013) 0.96
TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model. Pflugers Arch (2013) 0.95
Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle. J Biol Chem (2010) 0.95
TRIC channels supporting efficient Ca(2+) release from intracellular stores. Pflugers Arch (2012) 0.87
Genome wide association study of age at menarche in the Japanese population. PLoS One (2013) 0.85
Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis. Mol Cell (2016) 0.85
Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis. Circ Res (2014) 0.84
Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release. Biophys J (2013) 0.84
Ex vivo assessment of contractility, fatigability and alternans in isolated skeletal muscles. J Vis Exp (2012) 0.83
Effective population size, extended linkage disequilibrium and signatures of selection in the rare dog breed lundehund. PLoS One (2015) 0.83
Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels. J Biol Chem (2013) 0.81
Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J Membr Biol (2011) 0.81
Dual function of MG53 in membrane repair and insulin signaling. BMB Rep (2016) 0.81
New and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca(2+) release? J Physiol (2014) 0.79
Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta. PLoS Genet (2016) 0.77
Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel. Biochemistry (2011) 0.77
Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers. Biophys J (2014) 0.77
Structure of six-transmembrane cation channels revealed by single-particle analysis from electron microscopic images. J Synchrotron Radiat (2008) 0.77
Excitation-contraction coupling and minor triadic proteins in low-frequency fatigue. Exerc Sport Sci Rev (2010) 0.77
Ion channel activities in neural stem cells of the neuroepithelium. Stem Cells Int (2012) 0.76
Activation of SK2 channels preserves ER Ca(2+) homeostasis and protects against ER stress-induced cell death. Cell Death Differ (2015) 0.76
Crystal structures of the TRIC trimeric intracellular cation channel orthologues. Cell Res (2016) 0.76
Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach. Biophys J (2015) 0.76
Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology. Neuromuscul Disord (2016) 0.75
Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel. BMC Biol (2017) 0.75
Sarcoplasmic reticulum Ca(2+), Mg(2+), K(+), and Cl(-) concentrations adjust quickly as heart rate changes. J Mol Cell Cardiol (2016) 0.75
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A. J Physiol (2017) 0.75
Identification of a primary target of thalidomide teratogenicity. Science (2010) 7.09
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol (2008) 3.24
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nat Cell Biol (2005) 3.14
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation (2010) 2.35
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res (2010) 2.35
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med (2012) 2.27
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. J Biol Chem (2009) 2.25
Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity (2006) 2.21
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem (2007) 2.20
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2011) 2.06
Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Nat Cell Biol (2002) 2.03
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem (2006) 1.98
B cell antigen receptor signaling and internalization are mutually exclusive events. PLoS Biol (2006) 1.85
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev (2002) 1.83
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res (2010) 1.74
Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A (2012) 1.73
Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res (2005) 1.72
Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Am J Hum Genet (2013) 1.71
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol (2007) 1.70
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun (2004) 1.69
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. J Cell Biol (2006) 1.64
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation (2007) 1.63
FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J (2011) 1.61
MG53 regulates membrane budding and exocytosis in muscle cells. J Biol Chem (2008) 1.60
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci (2003) 1.59
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation (2010) 1.58
Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med (2012) 1.58
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells (2002) 1.51
A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB J (2011) 1.51
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. Proc Natl Acad Sci U S A (2010) 1.48
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophys J (2006) 1.48
Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. J Biol Chem (2006) 1.46
Topology representing network enables highly accurate classification of protein images taken by cryo electron-microscope without masking. J Struct Biol (2003) 1.44
Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development (2003) 1.44
Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb. Am J Hypertens (2010) 1.43
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Physiol Genomics (2005) 1.43
Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. J Hum Genet (2007) 1.40
Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. J Biol Chem (2011) 1.40
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther (2006) 1.39