Published in Mol Cell on July 06, 2007
Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A (2009) 2.65
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J (2010) 2.33
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell (2010) 2.08
The HTLV-1 Tax interactome. Retrovirology (2008) 2.02
Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell (2008) 1.93
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control. Nat Cell Biol (2010) 1.76
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis. EMBO J (2009) 1.66
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol (2010) 1.60
Control of cell growth by the SCF and APC/C ubiquitin ligases. Curr Opin Cell Biol (2009) 1.55
How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol (2011) 1.48
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol (2010) 1.38
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell (2008) 1.30
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol (2010) 1.28
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Mad2 prolongs DNA damage checkpoint arrest caused by a double-strand break via a centromere-dependent mechanism. Curr Biol (2010) 1.20
Cullin-RING Ligases as attractive anti-cancer targets. Curr Pharm Des (2013) 1.19
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell (2011) 1.15
The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol (2010) 1.14
Massively parallel sequencing and analysis of the Necator americanus transcriptome. PLoS Negl Trop Dis (2010) 1.12
Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1. EMBO J (2010) 1.12
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature (2014) 1.12
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J (2011) 1.11
The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit. J Cell Biol (2010) 1.11
Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol (2008) 1.11
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
Periodic mRNA synthesis and degradation co-operate during cell cycle gene expression. Mol Syst Biol (2014) 1.10
APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev Cell (2014) 1.09
Kinase signaling in the spindle checkpoint. J Biol Chem (2009) 1.09
MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics (2010) 1.08
Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C. EMBO J (2012) 1.07
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition. Proc Natl Acad Sci U S A (2010) 1.04
Evidence that human blastomere cleavage is under unique cell cycle control. J Assist Reprod Genet (2009) 1.03
State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02
Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail. Mol Biol Cell (2010) 1.01
Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1. EMBO J (2011) 1.01
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta (2014) 1.00
Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1. PLoS One (2011) 1.00
Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore. J Biol Chem (2013) 0.99
A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clin Cancer Res (2012) 0.99
Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. J Biol Chem (2008) 0.98
CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer. J Transl Med (2013) 0.98
Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. J Biol Chem (2012) 0.97
Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol Ther (2015) 0.97
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching. J Cell Biol (2008) 0.97
Proteomics of a fuzzy organelle: interphase chromatin. EMBO J (2014) 0.96
The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem (2014) 0.96
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases. J Biol Chem (2010) 0.96
Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit. Mol Cell Biol (2011) 0.96
Novel functions for the anaphase-promoting complex in neurobiology. Semin Cell Dev Biol (2011) 0.94
In-silico modeling of the mitotic spindle assembly checkpoint. PLoS One (2008) 0.94
Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. Mol Biol Cell (2010) 0.93
CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (2009) 0.92
Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther (2014) 0.91
Identification and classification of bcl genes and proteins of Bacillus cereus group organisms and their application in Bacillus anthracis detection and fingerprinting. Appl Environ Microbiol (2009) 0.91
Differential gene expression triggered by highly cytotoxic alpha-emitter-immunoconjugates in gastric cancer cells. Invest New Drugs (2009) 0.91
Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. PLoS One (2011) 0.91
Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10. J Biol Chem (2011) 0.91
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol (2010) 0.90
Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer. Exp Mol Pathol (2009) 0.90
CDC20 maintains tumor initiating cells. Oncotarget (2015) 0.90
Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev (2012) 0.90
A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog (2012) 0.89
Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. Cell Cycle (2015) 0.89
Regulation of APC/CCdc20 activity by RASSF1A-APC/CCdc20 circuitry. Oncogene (2011) 0.88
Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle (2011) 0.88
Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing. Cell Cycle (2012) 0.88
Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle (2011) 0.88
Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent. Toxicol Appl Pharmacol (2008) 0.88
Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes. J Virol (2010) 0.88
Transcriptional control of mitosis: deregulation and cancer. Front Endocrinol (Lausanne) (2015) 0.87
miR-125b promotes cell death by targeting spindle assembly checkpoint gene MAD1 and modulating mitotic progression. Cell Death Differ (2012) 0.87
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint. Cell Div (2007) 0.87
The emerging role of APC/CCdh1 in development. Semin Cell Dev Biol (2011) 0.86
Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol Biol Cell (2011) 0.86
p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses. Mol Cell Proteomics (2015) 0.86
Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. BMC Cancer (2012) 0.85
Meiotic control of the APC/C: similarities & differences from mitosis. Cell Div (2011) 0.85
The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. J Biol Chem (2013) 0.85
The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics (2015) 0.84
BubR1 is modified by sumoylation during mitotic progression. J Biol Chem (2011) 0.84
Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint. Cell Cycle (2013) 0.83
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation. Nat Commun (2016) 0.82
REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle (2012) 0.82
Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Mol Biol Cell (2010) 0.82
Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A (2015) 0.82
APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. J Biol Chem (2013) 0.82
Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open (2014) 0.80