Published in Cell Div on July 24, 2007
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
In-silico modeling of the mitotic spindle assembly checkpoint. PLoS One (2008) 0.94
Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. J Biol Chem (2013) 0.90
Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans. Cell Div (2008) 0.87
Mitotic Kinases and p53 Signaling. Biochem Res Int (2012) 0.78
Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1. OMICS (2015) 0.76
The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Mol Sci (2016) 0.75
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol (2006) 10.76
CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00
On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol (2001) 6.80
Budding yeast Cdc20: a target of the spindle checkpoint. Science (1998) 6.59
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J Cell Biol (1994) 6.38
The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell (2002) 6.26
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev (1998) 5.96
The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol (1998) 5.87
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell (2001) 5.82
Aneuploidy and cancer. Nature (2004) 5.61
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell (1998) 5.28
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature (2007) 4.31
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
The dynamic kinetochore-microtubule interface. J Cell Sci (2004) 4.07
Does aneuploidy cause cancer? Curr Opin Cell Biol (2006) 3.89
The spindle assembly checkpoint. Curr Opin Cell Biol (1996) 3.84
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol (2005) 3.77
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature (2004) 3.73
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell (2002) 3.65
The spindle checkpoint: tension versus attachment. Trends Cell Biol (2005) 3.63
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J (2003) 3.54
MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc Natl Acad Sci U S A (1997) 3.42
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell (2001) 3.36
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol (1998) 3.31
Cdc20: a WD40 activator for a cell cycle degradation machine. Mol Cell (2007) 3.14
Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol (2002) 3.04
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
Mitosis: a matter of getting rid of the right protein at the right time. Trends Cell Biol (2005) 2.74
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev (2001) 2.66
Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J (2001) 2.55
Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. Curr Biol (1998) 2.50
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage. Proc Natl Acad Sci U S A (1997) 2.23
D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev (2001) 2.20
APC/C and SCF: controlling each other and the cell cycle. Curr Biol (2004) 2.14
Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev (2004) 2.11
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PLoS One (2007) 2.08
The APC/C inhibitor, Emi1, is essential for prevention of rereplication. Genes Dev (2007) 2.03
How do so few control so many? Cell (2005) 2.00
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. Biochem Biophys Res Commun (1999) 1.93
The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol (2005) 1.90
The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curr Biol (2001) 1.88
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev (2001) 1.84
Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc Natl Acad Sci U S A (1998) 1.83
Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint. Nat Cell Biol (2003) 1.83
Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem Biophys Res Commun (2000) 1.74
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Proc Natl Acad Sci U S A (2007) 1.74
Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model. J Cell Biol (2006) 1.70
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem (2002) 1.64
Attachment and tension in the spindle assembly checkpoint. J Cell Sci (2002) 1.52
The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci (2006) 1.36
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc Natl Acad Sci U S A (2006) 1.33
Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci (2007) 1.32
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis. Cancer Res (2006) 1.09
Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry. Cell Cycle (2004) 1.03
APC/C--the master controller of origin licensing? Cell Div (2007) 1.02
Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check. Cell Cycle (2004) 0.93
Mitosis and checkpoints that control progression through mitosis in vertebrate somatic cells. Prog Cell Cycle Res (1997) 0.92
The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23. Arch Biochem Biophys (2002) 0.89
Identification of cell cycle-dependent phosphorylation sites on the anaphase-promoting complex/cyclosome by mass spectrometry. Methods Enzymol (2005) 0.86
Dual inhibition of Cdc20 by the spindle checkpoint. J Biomed Sci (2007) 0.82
Evidence that the yeast spindle assembly checkpoint has a target other than the anaphase promoting complex. Cell Cycle (2005) 0.77
Anaphase promoting complex or cyclosome? Cell Cycle (2005) 0.77
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol Cell (2006) 3.38
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol (2007) 3.15
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol (2005) 2.31
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J (2006) 2.13
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J (2003) 1.89
Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem (2003) 1.89
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr Biol (2013) 1.69
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68
Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci (2013) 1.66
Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem (2004) 1.63
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A (2004) 1.63
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Adsorption of ionizable organic contaminants on multi-walled carbon nanotubes with different oxygen contents. J Hazard Mater (2010) 1.45
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc (2009) 1.38
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem (2003) 1.35
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay. Methods Mol Biol (2004) 1.30
Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc (2010) 1.30
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
Selective detection of mercury (II) ion using nonlinear optical properties of gold nanoparticles. J Am Chem Soc (2008) 1.29
Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list. Mutat Res (2004) 1.28
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23
A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling. J Am Chem Soc (2013) 1.23
Toxicity and environmental risks of nanomaterials: challenges and future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2009) 1.22
KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. J Biol Chem (2006) 1.21
Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes. Chem Phys Lett (2008) 1.21
Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry (2007) 1.20
Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano (2010) 1.17
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell (2011) 1.15
Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast. Cell Cycle (2005) 1.13
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J (2011) 1.11
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem (2006) 1.10
Kinase signaling in the spindle checkpoint. J Biol Chem (2009) 1.09
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell (2011) 1.09
Effect of Surface Coating on the Toxicity of Silver Nanomaterials on Human Skin Keratinocytes. Chem Phys Lett (2010) 1.07
A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo. Genes Dev (2005) 1.07
Chloridodiphen-yl{[1-(1,3-thia-zol-2-yl-κN)ethyl-idene]-4-phenyl-thio-semicarbazidato-κN,S}tin(IV) methanol monosolvate. Acta Crystallogr Sect E Struct Rep Online (2011) 1.07
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One (2008) 1.06
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition. Proc Natl Acad Sci U S A (2010) 1.04
UVA light-induced DNA cleavage by isomeric methylbenz[a]anthracenes. Chem Res Toxicol (2002) 1.02
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev (2012) 1.02
A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ (2011) 1.00
Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry (2010) 1.00
Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation. Toxicol Ind Health (2006) 0.98
Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. J Biol Chem (2008) 0.98
Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene. Mutat Res (2003) 0.98
Seven-coordinate anion complex with a tren-based urea: binding discrepancy of hydrogen sulfate in solid and solution states. Org Biomol Chem (2011) 0.97
Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A (2013) 0.95
Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J (2003) 0.95
Limitation of the MTT and XTT assays for measuring cell viability due to superoxide formation induced by nano-scale TiO2. Toxicol In Vitro (2011) 0.95
Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2012) 0.93
Integrating plasmonic nanoparticles with TiO₂ photonic crystal for enhancement of visible-light-driven photocatalysis. Environ Sci Technol (2012) 0.92
Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One (2010) 0.90
Iodido{4-phenyl-1-[1-(1,3-thia-zol-2-yl-κN)ethyl-idene]thio-semicarbazidato-κN',S}{4-phenyl-1-[1-(1,3-thia-zol-2-yl)ethyl-idene]thio-semicarbazide-κS}mercury(II). Acta Crystallogr Sect E Struct Rep Online (2011) 0.90
Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes and dendritic cells. Int J Environ Res Public Health (2004) 0.90
Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14. J Biol Chem (2004) 0.90
Light-induced cytotoxicity of 16 polycyclic aromatic hydrocarbons on the US EPA priority pollutant list in human skin HaCaT keratinocytes: relationship between phototoxicity and excited state properties. Environ Toxicol (2007) 0.89
Phototoxicity and DNA damage induced by the cosmetic ingredient chemical azulene in human Jurkat T-cells. Mutat Res (2004) 0.89
Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res (2009) 0.89
Distinguishing "looped-out" and "stacked-in" DNA bulge conformation using fluorescent 2-aminopurine replacing a purine base. J Biomol Struct Dyn (2002) 0.88
Photodecomposition and phototoxicity of natural retinoids. Int J Environ Res Public Health (2005) 0.88
Synthesis and photoirradiation of isomeric ethylchrysenes by UVA light leading to lipid peroxidation. Int J Environ Res Public Health (2007) 0.87
Light-induced mutagenicity in Salmonella TA102 and genotoxicity/cytotoxicity in human T-cells by 3,3'-dichlorobenzidine: a chemical used in the manufacture of dyes and pigments and in tattoo inks. Toxicology (2005) 0.86
Quality assurance and safety of herbal dietary supplements. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2009) 0.86
Highly sensitive and selective dynamic light-scattering assay for TNT detection using p-ATP attached gold nanoparticle. ACS Appl Mater Interfaces (2010) 0.86
Photocatalytic oxidation of aqueous ammonia using atomic single layer graphitic-C3N4. Environ Sci Technol (2014) 0.85
Regulation of CDC14: pathways and checkpoints of mitotic exit. Front Biosci (2003) 0.85
Toxic effects of gold nanoparticles on Salmonella typhimurium bacteria. Toxicol Ind Health (2011) 0.85
DNA damage and repair of human skin keratinocytes concurrently exposed to pyrene derivatives and UVA light. Toxicol Res (Camb) (2013) 0.85
Toxicity of kava kava. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2008) 0.84
A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine. Vaccine (2008) 0.84
Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2 ) cells induced by synthetic azamacrocycle. Environ Toxicol (2012) 0.83
Label-free fluorescent detection of Cu(II) ions based on DNA cleavage-dependent graphene-quenched DNAzymes. Chem Commun (Camb) (2011) 0.83
Interface engineering catalytic graphene for smart colorimetric biosensing. ACS Nano (2012) 0.83
Gold Nanoparticle Based Surface Enhanced Fluorescence For Detection of Organophosphorus Agents. Chem Phys Lett (2008) 0.83
Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy. Chem Commun (Camb) (2011) 0.82
Photodegradation of selected PCBs in the presence of Nano-TiO2 as catalyst and H2O2 as an oxidant. Int J Environ Res Public Health (2010) 0.82