Published in J Bacteriol on July 06, 2007
Bacteriophage resistance mechanisms. Nat Rev Microbiol (2010) 7.38
Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature (2010) 5.92
Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol (2010) 3.59
Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci U S A (2011) 3.52
Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct (2009) 3.17
Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet (2009) 3.03
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet (2009) 2.89
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Mol Cell (2009) 2.74
The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proc Natl Acad Sci U S A (2009) 2.69
Antitoxin MqsA helps mediate the bacterial general stress response. Nat Chem Biol (2011) 2.30
Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol (2011) 2.19
Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res (2011) 2.19
Conjugative plasmids: vessels of the communal gene pool. Philos Trans R Soc Lond B Biol Sci (2009) 2.19
Comparative genomics of defense systems in archaea and bacteria. Nucleic Acids Res (2013) 1.82
Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol Microbiol (2009) 1.76
A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet (2009) 1.68
Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog (2009) 1.65
Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS Genet (2012) 1.62
Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem Biophys Res Commun (2009) 1.62
Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. J Bacteriol (2008) 1.61
What traits are carried on mobile genetic elements, and why? Heredity (Edinb) (2010) 1.49
Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem (2008) 1.49
Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes. PLoS One (2008) 1.49
Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ Microbiol (2010) 1.46
Chromosomal toxin-antitoxin systems may act as antiaddiction modules. J Bacteriol (2008) 1.46
To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems. Nucleic Acids Res (2013) 1.42
Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic Acids Res (2012) 1.40
Exposing plasmids as the Achilles' heel of drug-resistant bacteria. Curr Opin Chem Biol (2008) 1.34
Bacterial genome instability. Microbiol Mol Biol Rev (2014) 1.31
Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06. BMC Genomics (2010) 1.27
Insights on Escherichia coli biofilm formation and inhibition from whole-transcriptome profiling. Environ Microbiol (2009) 1.26
Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes. Antimicrob Agents Chemother (2009) 1.23
Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS Pathog (2012) 1.22
The other face of restriction: modification-dependent enzymes. Nucleic Acids Res (2013) 1.22
Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus. J Bacteriol (2009) 1.21
Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections. Front Cell Infect Microbiol (2014) 1.20
Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. MBio (2013) 1.19
Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression. J Bacteriol (2009) 1.18
Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia. J Bacteriol (2009) 1.15
The tmRNA ribosome-rescue system. Adv Protein Chem Struct Biol (2012) 1.15
Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends Microbiol (2012) 1.15
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One (2011) 1.13
Conjugative plasmids of Neisseria gonorrhoeae. PLoS One (2010) 1.12
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J Biol Chem (2010) 1.11
An SOS-regulated type 2 toxin-antitoxin system. J Bacteriol (2009) 1.09
The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics (2009) 1.08
Plasmid addiction systems: perspectives and applications in biotechnology. Microb Biotechnol (2010) 1.07
Signals of growth regulation in bacteria. Curr Opin Microbiol (2009) 1.06
Bacterial persistence increases as environmental fitness decreases. Microb Biotechnol (2012) 1.06
The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J Bacteriol (2010) 1.06
A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria. J Bacteriol (2012) 1.04
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis. J Bacteriol (2010) 1.01
Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles. Extremophiles (2011) 1.00
Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs. Toxins (Basel) (2014) 1.00
The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PLoS One (2010) 1.00
Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation. PLoS One (2008) 0.99
Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. BMC Microbiol (2013) 0.96
Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex. J Bacteriol (2008) 0.96
The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system. J Bacteriol (2010) 0.96
Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae. BMC Microbiol (2012) 0.95
Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. J Biol Chem (2011) 0.95
Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids. Proc Natl Acad Sci U S A (2014) 0.90
Within-host competition selects for plasmid-encoded toxin-antitoxin systems. Proc Biol Sci (2010) 0.88
Mechanisms of post-transcriptional gene regulation in bacterial biofilms. Front Cell Infect Microbiol (2014) 0.88
DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. Cold Spring Harb Perspect Biol (2013) 0.87
In vivo interactions between toxin-antitoxin proteins epsilon and zeta of streptococcal plasmid pSM19035 in Saccharomyces cerevisiae. J Bacteriol (2009) 0.87
Solution structure and membrane binding of the toxin fst of the par addiction module. Biochemistry (2010) 0.86
Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death. Int J Microbiol (2010) 0.85
Maintenance forced by a restriction-modification system can be modulated by a region in its modification enzyme not essential for methyltransferase activity. J Bacteriol (2008) 0.84
Toxin-antitoxin systems on the large defense plasmid pSYSA of Synechocystis sp. PCC 6803. J Biol Chem (2013) 0.83
Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems. Front Cell Infect Microbiol (2014) 0.83
Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin. PLoS One (2012) 0.82
Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. J Biol Chem (2010) 0.82
Type II toxin: antitoxin systems. More than small selfish entities? Curr Genet (2015) 0.82
Structural and thermodynamic characterization of Vibrio fischeri CcdB. J Biol Chem (2009) 0.81
What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence? Front Microbiol (2016) 0.81
Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module. J Biol Chem (2012) 0.81
Transcriptional responses to sucrose mimic the plant-associated life style of the plant growth promoting endophyte Enterobacter sp. 638. PLoS One (2015) 0.81
Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus. PLoS One (2015) 0.79
Association between toxin-antitoxin systems and biofilm formation. Jundishapur J Microbiol (2014) 0.79
YoeB toxin is activated during thermal stress. Microbiologyopen (2015) 0.78
Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in Helicobacter pylori and structural elucidation of their protein-protein interaction. J Biol Chem (2013) 0.78
Role of adaptor TrfA and ClpPC in controlling levels of SsrA-tagged proteins and antitoxins in Staphylococcus aureus. J Bacteriol (2014) 0.78
Mutational Analysis of the Antitoxin in the Lactococcal Type III Toxin-Antitoxin System AbiQ. Appl Environ Microbiol (2015) 0.78
Detection of endogenous MazF enzymatic activity in Staphylococcus aureus. Anal Biochem (2013) 0.78
Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity. Biochemistry (2013) 0.77
Type II Toxin-Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803. Toxins (Basel) (2016) 0.77
Crystallization of the Staphylococcus aureus MazF mRNA interferase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.77
Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803. PLoS One (2013) 0.77
Decoding toxicity: deducing the sequence requirements of IbsC, a type I toxin in Escherichia coli. J Biol Chem (2010) 0.77
Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans. PLoS One (2014) 0.77
Life, death, differentiation, and the multicellularity of bacteria. PLoS Genet (2009) 0.76
Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 Å resolution. Protein Sci (2014) 0.76
Prevalence of Haemophilus influenzae type b genetic islands among clinical and commensal H. influenzae and H. haemolyticus isolates. J Clin Microbiol (2010) 0.76
The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module. Front Microbiol (2016) 0.76
The ParE2-PaaA2 toxin-antitoxin complex from Escherichia coli O157 forms a heterodocecamer in solution and in the crystal. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.76
Sociomicrobiome of wood decay in a tropical rain forest: unraveling complexity. Springerplus (2013) 0.76
Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12. Toxins (Basel) (2017) 0.75
Prokaryotic toxin-antitoxin stress response loci. Nat Rev Microbiol (2005) 9.08
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res (2006) 7.93
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res (2005) 6.61
Selfish behavior of restriction-modification systems. Science (1995) 6.07
Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J Bacteriol (2004) 5.82
An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proc Natl Acad Sci U S A (1996) 5.25
MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Mol Cell (2003) 4.63
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. Science (2003) 4.55
RelE, a global inhibitor of translation, is activated during nutritional stress. Proc Natl Acad Sci U S A (2001) 4.10
Structured habitats and the evolution of anticompetitor toxins in bacteria. Proc Natl Acad Sci U S A (1981) 4.08
Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. J Mol Biol (2003) 3.76
Addiction modules and programmed cell death and antideath in bacterial cultures. Annu Rev Microbiol (1999) 3.58
Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet (2006) 3.56
Programmed death in bacteria. Microbiol Mol Biol Rev (2000) 3.49
Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Mol Microbiol (2002) 3.44
The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol Microbiol (1998) 3.26
Programmed cell death in bacteria: proteic plasmid stabilization systems. Mol Microbiol (1995) 3.21
Programmed cell death in bacterial populations. Science (1995) 3.14
Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. J Bacteriol (2000) 3.05
Bacterial persistence: a model of survival in changing environments. Genetics (2005) 2.97
Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Mol Microbiol (2003) 2.92
Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. J Bacteriol (2001) 2.88
Toxin-antitoxin modules as bacterial metabolic stress managers. Trends Biochem Sci (2005) 2.88
New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol (2003) 2.77
Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions. J Bacteriol (2004) 2.66
Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. Mol Microbiol (2003) 2.58
The nature and dynamics of bacterial genomes. Science (2006) 2.47
The relative contributions of recombination and point mutation to the diversification of bacterial clones. Curr Opin Microbiol (2001) 2.46
What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? J Bacteriol (2007) 2.29
Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol Microbiol (2004) 2.29
RNA antitoxins. Curr Opin Microbiol (2007) 2.26
MazF-mediated cell death in Escherichia coli: a point of no return. J Bacteriol (2004) 2.25
Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids. Mol Microbiol (2006) 2.00
Recognizing the pseudogenes in bacterial genomes. Nucleic Acids Res (2005) 1.96
rexB of bacteriophage lambda is an anti-cell death gene. Proc Natl Acad Sci U S A (1998) 1.95
Death's toolbox: examining the molecular components of bacterial programmed cell death. Mol Microbiol (2003) 1.93
Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1. Mol Genet Genomics (2004) 1.76
Postsegregational killing mediated by the P1 phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. J Bacteriol (2001) 1.75
Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. J Biol Chem (2004) 1.74
mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria. J Cell Sci (2005) 1.74
Exclusion of T4 phage by the hok/sok killer locus from plasmid R1. J Bacteriol (1996) 1.72
Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability. J Bacteriol (2006) 1.66
Corepression of the P1 addiction operon by Phd and Doc. J Bacteriol (1998) 1.62
Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids. Proc Natl Acad Sci U S A (2000) 1.55
A family of stability determinants in pathogenic bacteria. J Bacteriol (1998) 1.46
Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b. J Bacteriol (2004) 1.46
Shutdown decay of mRNA. Mol Microbiol (2006) 1.36
Diversity of restriction-modification gene homologues in Helicobacter pylori. Gene (2000) 1.35
Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems. Acta Biochim Pol (2001) 1.32
Toxin-antitoxin pairs in bacteria: killers or stress regulators? Cell (2003) 1.28
Genetic addiction: selfish gene's strategy for symbiosis in the genome. Genetics (2005) 1.27
Experimental genome evolution: large-scale genome rearrangements associated with resistance to replacement of a chromosomal restriction-modification gene complex. Mol Microbiol (2001) 1.25
Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. J Bacteriol (2007) 1.22
Translational coupling and limited degradation of a polycistronic messenger modulate differential gene expression in the parD stability system of plasmid R1. Mol Gen Genet (1995) 1.17
The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2. J Bacteriol (2006) 1.11
Modular organization of the Phd repressor/antitoxin protein. J Bacteriol (2004) 1.09
A family of anti-sigma70 proteins in T4-type phages and bacteria that are similar to AsiA, a Transcription inhibitor and co-activator of bacteriophage T4. J Mol Biol (2004) 1.06
RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system. J Bacteriol (2005) 1.04
Kid cleaves specific mRNAs at UUACU sites to rescue the copy number of plasmid R1. EMBO J (2005) 1.01
Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2. FEMS Microbiol Lett (1999) 0.98
TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. BMC Genomics (2006) 0.98
The type IC hsd loci of the enterobacteria are flanked by DNA with high homology to the phage P1 genome: implications for the evolution and spread of DNA restriction systems. Mol Microbiol (1997) 0.98
Characterization of the Phd repressor-antitoxin boundary. J Bacteriol (2005) 0.98
Selection for plasmid post-segregational killing depends on multiple infection: evidence for the selection of more virulent parasites through parasite-level competition. Proc Biol Sci (2005) 0.97
A bacteriophage T4 gene which functions to inhibit Escherichia coli Lon protease. J Bacteriol (1988) 0.96
Selfish genes. Science (1992) 0.90
Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cells under nutritional stress. Can J Microbiol (2006) 0.89
The newly characterized colicin Y provides evidence of positive selection in pore-former colicin diversification. Microbiology (2000) 0.89