Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow.

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Published in Nat Rev Microbiol on July 05, 2010

Authors

Rachel A F Wozniak1, Matthew K Waldor

Author Affiliations

1: Program in Genetics, Tufts University, Boston, Massachusetts 02111, USA.

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sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes. Nucleic Acids Res (2005) 1.52

Mobile antibiotic resistance encoding elements promote their own diversity. PLoS Genet (2009) 1.49

Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog (2012) 1.47

The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect Immun (2004) 1.40

Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci (2010) 1.39

Back to the future: studying cholera pathogenesis using infant rabbits. MBio (2010) 1.38

Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol (2006) 1.38

Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates. Microbiology (2002) 1.36

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Res (2013) 1.35

Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis (2011) 1.33

Synchronous replication initiation of the two Vibrio cholerae chromosomes. Curr Biol (2004) 1.31

Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage's life cycle. J Bacteriol (2003) 1.31

A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole. Genes Dev (2012) 1.29

Entering the era of bacterial epigenomics with single molecule real time DNA sequencing. Curr Opin Microbiol (2013) 1.29

Vibrio cholerae interactions with the gastrointestinal tract: lessons from animal studies. Curr Top Microbiol Immunol (2009) 1.27

RNase E-dependent processing stabilizes MicX, a Vibrio cholerae sRNA. Mol Microbiol (2007) 1.26

Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB. J Bacteriol (2006) 1.25

Formation of SXT tandem arrays and SXT-R391 hybrids. J Bacteriol (2004) 1.23

Genomic and functional analysis of ICEPdaSpa1, a fish-pathogen-derived SXT-related integrating conjugative element that can mobilize a virulence plasmid. J Bacteriol (2008) 1.22

Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization. Infect Immun (2008) 1.20

The locus of enterocyte effacement-encoded effector proteins all promote enterohemorrhagic Escherichia coli pathogenicity in infant rabbits. Infect Immun (2005) 1.19

ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA. Proc Natl Acad Sci U S A (2010) 1.19

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. MBio (2013) 1.19

Enterohemorrhagic Escherichia coli O157:H7 gal mutants are sensitive to bacteriophage P1 and defective in intestinal colonization. Infect Immun (2006) 1.18

A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins. Genes Dev (2011) 1.18

Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. MBio (2011) 1.17

SXT-related integrating conjugative element in New World Vibrio cholerae. Appl Environ Microbiol (2006) 1.17

Distinct centromere-like parS sites on the two chromosomes of Vibrio spp. J Bacteriol (2007) 1.16

Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins. Proc Natl Acad Sci U S A (2010) 1.14

CTXphi and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship. Mol Microbiol (2005) 1.14

Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol (2006) 1.14

Hfq negatively regulates type III secretion in EHEC and several other pathogens. Mol Microbiol (2009) 1.12

Interactions between inner membrane proteins in donor and recipient cells limit conjugal DNA transfer. Dev Cell (2005) 1.10

Identification of operators and promoters that control SXT conjugative transfer. J Bacteriol (2004) 1.10

The CTXphi repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes. J Biol Chem (2003) 1.08

Regulatory cross-talk links Vibrio cholerae chromosome II replication and segregation. PLoS Genet (2011) 1.06

EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cell Microbiol (2007) 1.06

A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Rep (2013) 1.04

Autorepression of RctB, an initiator of Vibrio cholerae chromosome II replication. J Bacteriol (2006) 1.00

Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J Bacteriol (2008) 0.99

Mining regulatory 5'UTRs from cDNA deep sequencing datasets. Nucleic Acids Res (2009) 0.99

Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7. J Bacteriol (2007) 0.98

Genetic analysis of activation of the Vibrio cholerae Cpx pathway. J Bacteriol (2009) 0.97

High-throughput sequencing reveals suppressors of Vibrio cholerae rpoE mutations: one fewer porin is enough. Nucleic Acids Res (2009) 0.96

Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A (2012) 0.96

An Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease. Antimicrob Agents Chemother (2011) 0.96

pIIICTX, a predicted CTXphi minor coat protein, can expand the host range of coliphage fd to include Vibrio cholerae. J Bacteriol (2003) 0.94

The SXT/R391 family of integrative conjugative elements is composed of two exclusion groups. J Bacteriol (2007) 0.94

Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res (2010) 0.93

Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol (2010) 0.93

The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. J Bacteriol (2010) 0.93

Vibrio cholerae LexA coordinates CTX prophage gene expression. J Bacteriol (2009) 0.93

Determinants of entry exclusion within Eex and TraG are cytoplasmic. J Bacteriol (2007) 0.92

ATP negatively regulates the initiator protein of Vibrio cholerae chromosome II replication. Proc Natl Acad Sci U S A (2008) 0.92

Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem (2010) 0.92

Substrate specificity of an elongation-specific peptidoglycan endopeptidase and its implications for cell wall architecture and growth of Vibrio cholerae. Mol Microbiol (2013) 0.91

Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae. Infect Immun (2014) 0.91

LexA represses CTXphi transcription by blocking access of the alpha C-terminal domain of RNA polymerase to promoter DNA. J Biol Chem (2006) 0.91

CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization. Infect Immun (2008) 0.91

A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization. Infect Immun (2012) 0.90

Global gene expression and phenotypic analysis of a Vibrio cholerae rpoH deletion mutant. J Bacteriol (2006) 0.89

ParP prevents dissociation of CheA from chemotactic signaling arrays and tethers them to a polar anchor. Proc Natl Acad Sci U S A (2013) 0.89

Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization. Infect Immun (2006) 0.88