Published in Trends Biochem Sci on July 10, 2007
Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9.33
p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med (2009) 2.44
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med (2011) 2.38
Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int J Biol Sci (2008) 2.18
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal (2009) 1.97
Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell (2010) 1.85
Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation. PLoS One (2014) 1.76
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle (2012) 1.67
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J (2012) 1.60
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
Cancer stem cells and the ontogeny of lung cancer. J Clin Oncol (2008) 1.51
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J (2009) 1.46
The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci (2008) 1.31
Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J (2010) 1.27
Reactive oxygen species: a double-edged sword in oncogenesis. World J Gastroenterol (2009) 1.25
MAPK signaling in inflammation-associated cancer development. Protein Cell (2010) 1.23
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem (2009) 1.20
Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer. PLoS Genet (2009) 1.19
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol (2012) 1.18
PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. Cancer Res (2010) 1.18
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci (2014) 1.10
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
Digitoxin and its analogs as novel cancer therapeutics. Exp Hematol Oncol (2012) 1.06
Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK. Patholog Res Int (2012) 1.04
Inflammation- and stress-related signaling pathways in hepatocarcinogenesis. World J Gastroenterol (2012) 1.04
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Mol Cell Biol (2011) 1.03
Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt. Cell Stress Chaperones (2009) 1.02
Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer. Oncogene (2013) 1.01
The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis. J Signal Transduct (2011) 0.98
Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK. Cytotechnology (2012) 0.95
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther (2011) 0.94
p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Sci Signal (2011) 0.93
Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC). Mol Ther (2013) 0.92
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus. Mol Cell Biol (2008) 0.90
Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res (2012) 0.90
p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein Cell (2010) 0.89
Direct transcriptional control of a p38 MAPK pathway by the circadian clock in Neurospora crassa. PLoS One (2011) 0.89
A connection between MAPK pathways and circadian clocks. Cell Cycle (2008) 0.88
PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res (2012) 0.88
Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response. Mech Ageing Dev (2009) 0.88
Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts. Cell Commun Signal (2012) 0.88
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Exp Hematol (2008) 0.84
Tumor promoting effects of CD95 signaling in chemoresistant cells. Mol Cancer (2010) 0.84
p38γ overexpression in gliomas and its role in proliferation and apoptosis. Sci Rep (2013) 0.84
Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem (2013) 0.84
Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells. J Biol Chem (2014) 0.84
Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. BMC Cancer (2015) 0.83
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine (2015) 0.83
Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer. FEBS J (2015) 0.82
The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines. Int J Oncol (2014) 0.82
Discovering and validating unknown phospho-sites from p38 and HuR protein kinases in vitro by Phosphoproteomic and Bioinformatic tools. J Clin Bioinforma (2011) 0.81
NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis (2015) 0.81
TIMP3 controls cell fate to confer hepatocellular carcinoma resistance. Oncogene (2014) 0.81
Regulatory Roles of MAPK Phosphatases in Cancer. Immune Netw (2016) 0.81
HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha. PLoS One (2008) 0.80
Diverse roles for MAPK signaling in circadian clocks. Adv Genet (2013) 0.79
Activation of PERK kinase in neural cells by proteasome inhibitor treatment. J Neurochem (2009) 0.78
OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. Br J Haematol (2011) 0.78
INTRACELLULAR SIGNALING BY BILE ACIDS. J Biosci (Rajshari) (2012) 0.78
Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis. J Med Food (2015) 0.78
An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence. BMC Genomics (2011) 0.78
Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol (2015) 0.78
Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. Sci Rep (2013) 0.77
p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. Stem Cell Reports (2016) 0.77
Co-expressed Cyclin D variants cooperate to regulate proliferation of germline nuclei in a syncytium. Cell Cycle (2015) 0.77
Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population. Int J Clin Exp Pathol (2015) 0.75
Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer. BMC Cancer (2016) 0.75
Triptolide exerts pro-apoptotic and cell cycle arrest activity on drug-resistant human lung cancer A549/Taxol cells via modulation of MAPK and PI3K/Akt signaling pathways. Oncol Lett (2016) 0.75
Loss of MKK3 and MK2 Copy Numbers in Non-Small Cell Lung Cancer. J Cancer (2016) 0.75
Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38/JNK/ERK signal pathway. Am J Transl Res (2017) 0.75
TES inhibits colorectal cancer progression through activation of p38. Oncotarget (2016) 0.75
A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs. Sci Rep (2017) 0.75
The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK. Oncogene (2015) 0.75
Biomarkers and mechanisms associated with recurrent prostate cancer. Front Biosci (Landmark Ed) (2014) 0.75
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep (2017) 0.75
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol (2002) 2.70
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem (2003) 1.76
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle (2012) 1.67
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell (2005) 1.51
Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc Natl Acad Sci U S A (2004) 1.38
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. Cancer Res (2004) 1.33
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol (2007) 1.17
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus. Nat Struct Mol Biol (2004) 1.16
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
GammaD-crystallin associated protein aggregation and lens fiber cell denucleation. Invest Ophthalmol Vis Sci (2007) 1.06
Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. J Virol (2004) 1.05
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Mol Cell Biol (2011) 1.03
A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence. Mol Cell (2013) 0.98
The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins. Cancer Res (2005) 0.97
p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein Cell (2010) 0.89
PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res (2012) 0.88
Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence. Mol Cell Biol (2013) 0.84
The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance. Mol Biol Cell (2007) 0.80
Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. Cell Cycle (2015) 0.79
Simple whole-cell biodetection and bioremediation of heavy metals based on an engineered lead-specific operon. Environ Sci Technol (2014) 0.79
Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB. J Am Chem Soc (2015) 0.76