Published in Protein Cell on June 01, 2010
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2-Chloroethanol Induced Upregulation of Matrix Metalloproteinase-2 in Primary Cultured Rat Astrocytes Via MAPK Signal Pathways. Front Neurosci (2017) 0.75
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Upregulation of Matrix Metalloproteinase-9 in Primary Cultured Rat Astrocytes Induced by 2-Chloroethanol Via MAPK Signal Pathways. Front Cell Neurosci (2017) 0.75
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Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol (2008) 1.68
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J (2006) 1.65
Cellular UV damage responses--functions of tumor suppressor p53. Biochim Biophys Acta (2005) 1.65
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A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem (2001) 1.41
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In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol Chem (2002) 1.37
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology (2010) 1.31
Who's on first in the cellular response to DNA damage? Nat Rev Mol Cell Biol (2003) 1.30
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol (2003) 1.24
Hepatitis B virus X protein inhibits nucleotide excision repair. Int J Cancer (1999) 1.22
The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. J Biol Chem (2008) 0.99
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Activation and signaling of the p38 MAP kinase pathway. Cell Res (2005) 5.48
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem (2008) 3.52
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity (2007) 3.38
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol (2002) 2.70
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells (2003) 2.28
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell (2007) 2.21
Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron (2004) 2.17
The pathways to tumor suppression via route p38. Trends Biochem Sci (2007) 2.15
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell (2006) 2.06
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem (2004) 1.96
Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem (2006) 1.87
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem (2006) 1.86
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem (2006) 1.79
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem (2003) 1.76
Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol (2008) 1.68
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem (2002) 1.67
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle (2012) 1.67
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.62
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem (2002) 1.59
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes (2006) 1.58
Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol (2007) 1.57
The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res (2005) 1.57
Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell (2005) 1.51
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem (2004) 1.48
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem (2013) 1.48
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem (2002) 1.44
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood (2005) 1.44
A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43
MicroRNAs and cardiovascular diseases. FEBS J (2011) 1.41
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem (2007) 1.39
Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res (2003) 1.39
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38
Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc Natl Acad Sci U S A (2004) 1.38
Activities of human DNA polymerase kappa in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion. DNA Repair (Amst) (2002) 1.37
Direct-current electrical field guides neuronal stem/progenitor cell migration. Stem Cells (2008) 1.34
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. Cancer Res (2004) 1.33
Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol (2007) 1.33
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology (2010) 1.31
Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell (2003) 1.30
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. J Biol Chem (2002) 1.29
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem (2005) 1.28
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.27
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci (2003) 1.27
Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc Natl Acad Sci U S A (2010) 1.27
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem (2002) 1.26
Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Tissue Eng Part C Methods (2008) 1.26
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci U S A (2004) 1.25
Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J Biol Chem (2006) 1.25
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells. Hum Mol Genet (2006) 1.24
MAPK signaling in inflammation-associated cancer development. Protein Cell (2010) 1.23
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem (2002) 1.21
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med (2013) 1.21
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo. Blood (2009) 1.20
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol (2008) 1.20
Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res (2011) 1.20
Erk1 positively regulates osteoclast differentiation and bone resorptive activity. PLoS One (2011) 1.19
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem (2002) 1.19
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem (2002) 1.19
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer. Clin Cancer Res (2011) 1.19
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. Biochim Biophys Acta (2007) 1.18
RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta (2008) 1.18
Multiple increased osteoclast functions in individuals with neurofibromatosis type 1. Am J Med Genet A (2011) 1.18
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem (2004) 1.18
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol (2007) 1.17
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus. Nat Struct Mol Biol (2004) 1.16
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
Radical abdominal trachelectomy for cervical malignancies: surgical, oncological and fertility outcomes in 62 patients. Gynecol Oncol (2011) 1.14
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem (2007) 1.14
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis (2010) 1.14
Determination of lead in water samples by graphite furnace atomic absorption spectrometry after cloud point extraction. Talanta (2005) 1.14
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. J Biol Chem (2002) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Nod1-dependent control of tumor growth. Proc Natl Acad Sci U S A (2006) 1.13