PubRank

Michael R Freeman

Author PubWeight™ 104.38‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest 2005 2.89
2 Single photon-emission computed tomography. J Nucl Cardiol 2010 2.57
3 Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics 2009 2.16
4 Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res 2002 2.11
5 Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res 2009 2.07
6 Ontario multidetector computed tomographic coronary angiography study: field evaluation of diagnostic accuracy. Arch Intern Med 2011 1.97
7 Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. PLoS One 2012 1.89
8 An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle 2009 1.88
9 Do the cholesterol-lowering properties of statins affect cancer risk? Trends Endocrinol Metab 2008 1.74
10 The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J 2007 1.69
11 Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol 2003 1.65
12 Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol 2012 1.60
13 The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle 2012 1.56
14 Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 2007 1.56
15 Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res 2007 1.45
16 The role of cholesterol in prostate cancer. Curr Opin Clin Nutr Metab Care 2006 1.43
17 Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med 2007 1.38
18 Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin. Cancer Res 2005 1.31
19 Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 2002 1.30
20 Cholesterol and prostate cancer. Curr Opin Pharmacol 2012 1.28
21 Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem 2007 1.23
22 Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle 2008 1.20
23 The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol 2007 1.20
24 Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett 2003 1.19
25 Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol 2009 1.18
26 Optimizing sample handling for urinary proteomics. J Proteome Res 2008 1.18
27 Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics 2004 1.17
28 A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics 2005 1.15
29 Proteomic analysis of palmitoylated platelet proteins. Blood 2011 1.14
30 p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett 2007 1.14
31 The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res 2007 1.13
32 The complex interplay between cholesterol and prostate malignancy. Urol Clin North Am 2011 1.13
33 Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle 2013 1.12
34 An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor. In Vitro Cell Dev Biol Anim 2010 1.10
35 Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo) 2006 1.07
36 Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development. Am J Pathol 2006 1.06
37 Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress. Cancer Res 2005 1.04
38 Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses. J Am Coll Cardiol 2002 1.03
39 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One 2013 1.03
40 Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res 2009 1.02
41 Cholesterol and cholesterol-rich membranes in prostate cancer: an update. Tumori 2008 1.02
42 Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Res 2002 1.02
43 Proteomic approaches to the analysis of multiprotein signaling complexes. Proteomics 2008 1.01
44 DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol Med 2012 1.01
45 Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology 2003 1.00
46 A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma. Cancer Res 2003 1.00
47 Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. Arterioscler Thromb Vasc Biol 2007 0.99
48 VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol 2008 0.98
49 Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology 2002 0.97
50 Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J Urol 2003 0.96
51 Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. BJU Int 2008 0.95
52 MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling. Cancer Res 2011 0.95
53 Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J 2004 0.94
54 Quantitative proteomics identifies a beta-catenin network as an element of the signaling response to Frizzled-8 protein-related antiproliferative factor. Mol Cell Proteomics 2011 0.94
55 Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer 2008 0.94
56 Antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome. Int Neurourol J 2011 0.94
57 RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization. Endocr Relat Cancer 2014 0.93
58 Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. Proteomics 2013 0.93
59 Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther 2007 0.92
60 Suppression of aberrant transient receptor potential cation channel, subfamily V, member 6 expression in hyperproliferative colonic crypts by dietary calcium. Am J Physiol Gastrointest Liver Physiol 2010 0.90
61 Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. Exp Cell Res 2006 0.90
62 'Omics' approaches to understanding interstitial cystitis/painful bladder syndrome/bladder pain syndrome. Int Neurourol J 2012 0.90
63 Management of chronic prostatitis/chronic pelvic pain syndrome: an evidence-based approach. Urology 2006 0.89
64 Cardiac imaging for risk stratification in diabetes. Diabetes Care 2007 0.89
65 Cholesterol-regulated stress fiber formation. J Cell Biochem 2009 0.89
66 A signaling network in phenylephrine-induced benign prostatic hyperplasia. Endocrinology 2009 0.88
67 Statins and the risk of cancer. JAMA 2006 0.88
68 Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers. J Proteome Res 2014 0.87
69 Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics 2008 0.87
70 VentX trans-activates p53 and p16ink4a to regulate cellular senescence. J Biol Chem 2011 0.86
71 Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer. J Proteome Res 2010 0.85
72 Proteomics and opportunities for clinical translation in urological disease. J Urol 2009 0.84
73 Caveolae are negative regulators of transforming growth factor-beta1 signaling in ureteral smooth muscle cells. J Urol 2004 0.84
74 The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network. PLoS One 2012 0.84
75 JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells. Breast Cancer Res Treat 2003 0.84
76 Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells. Prostate 2003 0.84
77 Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. BJU Int 2012 0.83
78 Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment. Proteomics 2014 0.83
79 Hypercholesterolemia promotes an osteoporotic phenotype. Am J Pathol 2012 0.82
80 An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. J Cell Biochem 2005 0.82
81 Drug delivery systems in urology--getting "smarter". Urology 2006 0.81
82 Beta2 microglobulin: a surprising therapeutic target for prostate cancer and renal cell carcinoma. J Urol 2007 0.81
83 Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma. Neuropathology 2005 0.81
84 Increasing the ranks of physician-scientists in urology through the promotion of fellowship training: the example of pediatric urology. J Urol 2005 0.80
85 The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells. Urology 2002 0.80
86 Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Lab Invest 2006 0.79
87 Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia. J Urol 2010 0.78
88 Growth and stretch response of human exstrophy bladder smooth muscle cells: molecular evidence of normal intrinsic function. BJU Int 2005 0.77
89 A synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2. PLoS One 2012 0.77
90 Behavioral profiling of human transitional cell carcinoma ex vivo. Cancer Res 2006 0.76
91 Left ventricular function during arm exercise: influence of leg cycling and lower body positive pressure. J Appl Physiol (1985) 2006 0.76
92 Growing evidence that radionuclide imaging identifies management strategies that improve outcome. J Nucl Cardiol 2009 0.75
93 Using the appropriate fishing net for computed tomographic coronary angiography in daily clinical practice. Arch Intern Med 2011 0.75
94 Words of wisdom. Re: Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Eur Urol 2013 0.75
95 Endocardial cryotherapy as a novel strategy of improving myocardial perfusion in a patient with severe coronary artery disease. Catheter Cardiovasc Interv 2003 0.75
96 Cardiac encasement by metastatic myxoid liposarcoma. Cardiovasc Pathol 2002 0.75