Published in J Biol Chem on July 16, 2007
RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nat Struct Mol Biol (2012) 1.40
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains. Nat Struct Mol Biol (2009) 1.35
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. PLoS One (2010) 1.25
Threshold-controlled ubiquitination of the EGFR directs receptor fate. EMBO J (2013) 1.11
The MET axis as a therapeutic target. Update Cancer Ther (2009) 0.98
Macromolecular juggling by ubiquitylation enzymes. BMC Biol (2013) 0.95
Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association. PLoS One (2011) 0.88
Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights. Protein Sci (2008) 0.86
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery. EMBO Rep (2013) 0.84
Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer. J Biol Chem (2012) 0.83
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells. Nat Commun (2015) 0.76
Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. BMC Biol (2016) 0.75
Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68
The BCL-2 family reunion. Mol Cell (2010) 7.32
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell (2012) 4.47
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell (2011) 3.72
Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science (2013) 2.84
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24
Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell (2003) 2.24
Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Breast Cancer Res (2006) 2.12
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc Natl Acad Sci U S A (2009) 2.01
Regulation of endocytosis via the oxygen-sensing pathway. Nat Med (2009) 2.00
An NMR approach to structural proteomics. Proc Natl Acad Sci U S A (2002) 1.95
miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab (2010) 1.89
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proc Natl Acad Sci U S A (2012) 1.80
Breast cancer - one term, many entities? J Clin Invest (2011) 1.72
Crosstalk in Met receptor oncogenesis. Trends Cell Biol (2009) 1.70
Protein quality control in the ER: the recognition of misfolded proteins. Semin Cell Dev Biol (2010) 1.69
Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med (2005) 1.66
Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol (2005) 1.65
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell (2007) 1.60
SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol Cell (2009) 1.59
Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity. Cancer Res (2009) 1.58
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem (2002) 1.57
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature (2008) 1.55
BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem (2010) 1.52
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. EMBO J (2003) 1.52
BID-induced structural changes in BAK promote apoptosis. Nat Struct Mol Biol (2013) 1.45
Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions. J Biol Chem (2005) 1.44
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J Biol Chem (2005) 1.39
A structural overview of the PDI family of proteins. FEBS J (2010) 1.38
Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. J Biol Chem (2007) 1.37
Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell (2002) 1.34
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. J Biol Chem (2010) 1.34
Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. J Neurosci (2006) 1.33
Crystal structure of the bb' domains of the protein disulfide isomerase ERp57. Structure (2006) 1.33
Solution structure of the bb' domains of human protein disulfide isomerase. FEBS J (2009) 1.32
GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev Cell (2011) 1.31
Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. J Biol Chem (2010) 1.31
Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Mol Cell Biol (2008) 1.30
HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion. Mol Biol Cell (2004) 1.26
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties. PLoS One (2010) 1.26
Structural basis of carbohydrate recognition by calreticulin. J Biol Chem (2010) 1.25
Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Proc Natl Acad Sci U S A (2012) 1.23
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol (2009) 1.23
The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Oncogene (2005) 1.22
Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. J Biol Chem (2004) 1.22
Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Res (2012) 1.20
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. J Biol Chem (2003) 1.19
Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clin Cancer Res (2010) 1.19
CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells. Mol Cancer Res (2005) 1.18
A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. J Biol Chem (2004) 1.17
Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system. EMBO J (2004) 1.16
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc Natl Acad Sci U S A (2004) 1.15
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15
Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. Proc Natl Acad Sci U S A (2013) 1.14
Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions. J Mol Biol (2002) 1.11
ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity. J Biol Chem (2009) 1.11
Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein. J Mol Biol (2010) 1.11
Diagnostic accuracy of conventional and cholangioscopy-guided sampling of indeterminate biliary lesions at the time of ERCP: a prospective, long-term follow-up study. Gastrointest Endosc (2012) 1.10
Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G. Mol Cell (2012) 1.10
Detection of myelination using a novel histological probe. J Histochem Cytochem (2005) 1.09
Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat Struct Mol Biol (2010) 1.09
Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. Am J Physiol Endocrinol Metab (2009) 1.08
Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Biochemistry (2006) 1.08
Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). J Biol Chem (2011) 1.08
Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J Biol Chem (2006) 1.07
Solution structure of the carbon storage regulator protein CsrA from Escherichia coli. J Bacteriol (2005) 1.07
Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain. J Biol Chem (2003) 1.07
Structural and functional relationships between the lectin and arm domains of calreticulin. J Biol Chem (2011) 1.05
Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. J Biol Chem (2010) 1.05
Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily. J Biol Chem (2003) 1.04
Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. Mol Biol Cell (2002) 1.04
Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc Natl Acad Sci U S A (2013) 1.04
In vivo wound healing and antibacterial performances of electrospun nanofibre membranes. J Biomed Mater Res A (2010) 1.03
Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program. J Biol Chem (2002) 1.03
Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. EMBO J (2004) 1.03
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem (2005) 1.02
Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem (2010) 1.02
Magnetic liquid marbles: manipulation of liquid droplets using highly hydrophobic Fe3O4 nanoparticles. Adv Mater (2010) 1.02
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. Mol Cell Biol (2010) 1.02
Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. Biol Psychiatry (2006) 1.01
Prospective evaluation of the clinical utility of ERCP-guided cholangiopancreatoscopy with a new direct visualization system. Gastrointest Endosc (2011) 1.00
Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72. Structure (2009) 1.00
Crk adaptor proteins act as key signaling integrators for breast tumorigenesis. Breast Cancer Res (2012) 0.98
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res (2010) 0.98
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98
NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding. Biochemistry (2005) 0.98
Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. J Biol Chem (2007) 0.97