Published in J Am Chem Soc on July 27, 2007
Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org Biomol Chem (2009) 0.88
An optimized pyrimidinol multifunctional radical quencher. ACS Med Chem Lett (2013) 0.76
3-Pyridinols and 5-pyrimidinols: Tailor-made for use in synergistic radical-trapping co-antioxidant systems. Beilstein J Org Chem (2013) 0.76
Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1. PLoS One (2014) 0.75
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci (2017) 0.75
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99
Vitamin E, antioxidant and nothing more. Free Radic Biol Med (2007) 3.87
Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chem Biol (2007) 2.29
Free radical lipid peroxidation: mechanisms and analysis. Chem Rev (2011) 2.17
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chem Res Toxicol (2008) 1.82
Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J Biol Chem (2008) 1.76
Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A (2002) 1.63
Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. J Am Chem Soc (2009) 1.58
An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. Mol Cell Proteomics (2009) 1.52
Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1. Blood (2009) 1.51
Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat. J Hypertens (2010) 1.49
Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma. Clin Cancer Res (2007) 1.44
Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. J Lipid Res (2010) 1.44
New insights regarding the autoxidation of polyunsaturated fatty acids. Antioxid Redox Signal (2005) 1.42
Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy. Mol Ther (2011) 1.39
World No Tobacco Day (31 May 2007)--did anybody notice? N Z Med J (2007) 1.38
Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas. Clin Cancer Res (2011) 1.35
Release of high-energy water as an essential driving force for the high-affinity binding of cucurbit[n]urils. J Am Chem Soc (2012) 1.31
Ligand specificity in the CRAL-TRIO protein family. Biochemistry (2003) 1.29
Identification of proteins adducted by lipid peroxidation products in plasma and modifications of apolipoprotein A1 with a novel biotinylated phospholipid probe. J Proteome Res (2008) 1.28
Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies. J Am Chem Soc (2010) 1.27
Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem (2006) 1.25
An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 1.25
Garlic: source of the ultimate antioxidants--sulfenic acids. Angew Chem Int Ed Engl (2009) 1.24
Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. J Am Chem Soc (2003) 1.23
A conformational flexibility scale for amino acids in peptides. Angew Chem Int Ed Engl (2003) 1.18
Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem (2010) 1.17
Label-free continuous enzyme assays with macrocycle-fluorescent dye complexes. Nat Methods (2007) 1.15
Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem (2008) 1.15
The sensory dorsal organs of crustaceans. Biol Rev Camb Philos Soc (2012) 1.14
Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. Mol Nutr Food Res (2009) 1.13
Alkylation damage by lipid electrophiles targets functional protein systems. Mol Cell Proteomics (2014) 1.13
Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin. J Biol Chem (2010) 1.13
Peroxyl radical clocks. J Org Chem (2006) 1.13
Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Proc Natl Acad Sci U S A (2007) 1.12
Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J Biol Chem (2003) 1.11
Molecular determinants of sphingomyelin specificity of a eukaryotic pore-forming toxin. J Biol Chem (2008) 1.09
Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem (2006) 1.09
Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Free Radic Biol Med (2010) 1.08
A fluorescence-based method for direct measurement of submicrosecond intramolecular contact formation in biopolymers: an exploratory study with polypeptides. J Am Chem Soc (2002) 1.07
Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios. Chem Res Toxicol (2010) 1.07
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. J Biol Chem (2011) 1.07
Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer (2004) 1.07
Dissecting the mechanisms of a class of chemical glycosylation using primary ¹³C kinetic isotope effects. Nat Chem (2012) 1.07
DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiol Dis (2011) 1.05
Kinetics of end-to-end collision in short single-stranded nucleic acids. J Am Chem Soc (2004) 1.05
Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Mol Cancer Ther (2003) 1.05
The hydrophobic effect revisited--studies with supramolecular complexes imply high-energy water as a noncovalent driving force. Angew Chem Int Ed Engl (2014) 1.04
Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. J Inherit Metab Dis (2012) 1.04
Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein. J Lipid Res (2005) 1.04
Mechanism of host-guest complexation by cucurbituril. J Am Chem Soc (2004) 1.03
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates. Biochem Pharmacol (2002) 1.03
Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Anal Chem (2003) 1.03
Critical re-evaluation of the O-H bond dissociation enthalpy in phenol. J Phys Chem A (2005) 1.03
Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. J Lipid Res (2013) 1.02
Fluorescent dyes and their supramolecular host/guest complexes with macrocycles in aqueous solution. Chem Rev (2011) 1.02
A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J Pharmacol Exp Ther (2011) 1.02
Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification. Circulation (2008) 1.01
Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Chem Res Toxicol (2004) 1.01
Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. J Biol Chem (2005) 1.01
Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Anal Chem (2005) 1.01
Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks. Acc Chem Res (2011) 1.01
Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition. Structure (2012) 0.99
Stable polymethacrylate nanocapsules from ultraviolet light-induced template radical polymerization of unilamellar liposomes. Langmuir (2006) 0.99
Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Nat Chem Biol (2010) 0.99
Comparative effects of the angiotensin II receptor blocker, telmisartan, and the angiotensin-converting enzyme inhibitor, ramipril, on cerebrovascular structure in spontaneously hypertensive rats. J Hypertens (2005) 0.99
Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem (2002) 0.99
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 0.99
Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radic Biol Med (2012) 0.99
Factors influencing the autoxidation of fatty acids: effect of olefin geometry of the nonconjugated diene. J Am Chem Soc (2004) 0.98
Identification of a novel class of endoperoxides from arachidonate autoxidation. J Biol Chem (2003) 0.98
Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. J Biol Chem (2003) 0.98
Binding of inorganic cations by p-sulfonatocalix[4]arene monitored through competitive fluorophore displacement in aqueous solution. Chem Commun (Camb) (2005) 0.98
Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Biochemistry (2006) 0.98
Cucurbiturils: from synthesis to high-affinity binding and catalysis. Chem Soc Rev (2015) 0.98
The unusual reaction of semiquinone radicals with molecular oxygen. J Org Chem (2008) 0.98
Dynamically self-assembling metalloenzyme models based on calixarenes. Angew Chem Int Ed Engl (2006) 0.97
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochim Biophys Acta (2012) 0.96
Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA. Cancer Res (2004) 0.96
Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. Chem Res Toxicol (2007) 0.96
Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer Chemother Pharmacol (2004) 0.95
Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.95
Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation. Free Radic Biol Med (2009) 0.95
Molecular determinants of heritable vitamin E deficiency. Biochemistry (2004) 0.95
The strategic use of supramolecular pK(a) shifts to enhance the bioavailability of drugs. Adv Drug Deliv Rev (2012) 0.95
Efficient fluorescence enhancement and cooperative binding of an organic dye in a supra-biomolecular host-protein assembly. Angew Chem Int Ed Engl (2007) 0.95
6-Amino-3-pyridinols: towards diffusion-controlled chain-breaking antioxidants. Angew Chem Int Ed Engl (2003) 0.95
Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells. Anal Chem (2015) 0.94
Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. Chem Res Toxicol (2008) 0.94
Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. Biochem J (2012) 0.94
Mechanisms of ligand transfer by the hepatic tocopherol transfer protein. J Biol Chem (2008) 0.93
Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal. Lipids (2005) 0.93
Separation and identification of F2-isoprostane regioisomers and diastereomers by novel liquid chromatographic/mass spectrometric methods. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.93
Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. J Am Chem Soc (2002) 0.93