Published in Biochemistry on July 27, 2007
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov (2010) 3.84
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
The 3Ms of central spindle assembly: microtubules, motors and MAPs. Nat Rev Mol Cell Biol (2009) 2.88
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest (2009) 2.13
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science (2015) 1.92
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biol (2010) 1.60
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem (2008) 1.54
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol (2012) 1.47
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res (2009) 1.37
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chem Rev (2013) 1.35
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proc Natl Acad Sci U S A (2013) 1.24
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks. J Biol Chem (2009) 1.15
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene (2011) 1.13
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. EMBO J (2010) 1.11
PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis. Childs Nerv Syst (2017) 1.05
Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell (2012) 1.05
Polo-like kinase 4: the odd one out of the family. Cell Div (2010) 1.03
Proteotoxic stress increases nuclear localization of ataxin-3. Hum Mol Genet (2009) 1.02
PLK1 down-regulates parainfluenza virus 5 gene expression. PLoS Pathog (2009) 1.02
Binding of STIL to Plk4 activates kinase activity to promote centriole assembly. J Cell Biol (2015) 1.02
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. J Neurosci Res (2010) 1.00
A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage. Mol Biol Cell (2010) 0.99
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. PLoS One (2010) 0.97
Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs. Dev Biol (2008) 0.94
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei. Mol Biol Cell (2015) 0.92
Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. Int J Cancer (2011) 0.92
Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity. Mol Cells (2011) 0.90
Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation. Cell Calcium (2009) 0.88
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy. Trends Pharmacol Sci (2015) 0.87
Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation. PLoS One (2013) 0.85
Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development. Protein Cell (2012) 0.83
Inhibition of polo-like kinase 1 induces cell cycle arrest and sensitizes glioblastoma cells to ionizing radiation. Cancer Biother Radiopharm (2013) 0.81
A novel role for Plk4 in regulating cell spreading and motility. Oncogene (2014) 0.79
PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis. Biomed Res Int (2015) 0.77
Identification and functional characterization of polo-like kinase 2 autoregulatory sites. Neuroscience (2011) 0.77
Identification of ChIP-seq mapped targets of HP1β due to bombesin/GRP receptor activation. Clin Epigenetics (2011) 0.77
Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen. Assay Drug Dev Technol (2010) 0.77
Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected]. PLoS One (2014) 0.76
KinView: a visual comparative sequence analysis tool for integrated kinome research. Mol Biosyst (2016) 0.76
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res (2007) 5.75
ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med (2014) 4.90
Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies. J Clin Oncol (2009) 4.14
S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell (2003) 4.03
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther (2005) 2.15
Hepatocellular carcinoma: stiffness value and ratio to discriminate malignant from benign focal liver lesions. Radiology (2015) 2.03
Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro. Antimicrob Agents Chemother (2004) 1.87
Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro. Antimicrob Agents Chemother (2005) 1.75
On the evolutionary history, population genetics and diversity among isolates of Salmonella Enteritidis PFGE pattern JEGX01.0004. PLoS One (2013) 1.69
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem (2009) 1.68
High resolution clustering of Salmonella enterica serovar Montevideo strains using a next-generation sequencing approach. BMC Genomics (2012) 1.68
Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. Cancer Biol Ther (2009) 1.60
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem (2004) 1.56
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. J Med Chem (2002) 1.55
Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chem Res Toxicol (2007) 1.53
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest (2010) 1.52
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol (2007) 1.52
Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol (2006) 1.50
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest (2006) 1.46
Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem (2010) 1.44
Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biol Ther (2008) 1.43
Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res (2009) 1.41
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature (2013) 1.40
Hepatic perfusion disorder associated with focal liver lesions: contrast-enhanced US patterns--correlation study with contrast-enhanced CT. Radiology (2011) 1.39
ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. Clin Cancer Res (2009) 1.36
Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes. Invest Ophthalmol Vis Sci (2008) 1.32
Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol (2008) 1.32
Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals. Cancer Res (2005) 1.28
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med (2010) 1.28
MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem (2007) 1.27
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks. Mol Cancer Res (2008) 1.27
Updates of mTOR inhibitors. Anticancer Agents Med Chem (2010) 1.27
Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways. Mol Cancer Res (2009) 1.26
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorg Med Chem Lett (2009) 1.23
Crystal structure of PhnH: an essential component of carbon-phosphorus lyase in Escherichia coli. J Bacteriol (2007) 1.22
Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab (2006) 1.21
Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series. Biochemistry (2003) 1.19
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther (2009) 1.18
Phylogenetic analysis of non-O157 Shiga toxin-producing Escherichia coli strains by whole-genome sequencing. J Clin Microbiol (2012) 1.18
Whole-genome sequencing of gentamicin-resistant Campylobacter coli isolated from U.S. retail meats reveals novel plasmid-mediated aminoglycoside resistance genes. Antimicrob Agents Chemother (2013) 1.16
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals. Genome Biol Evol (2014) 1.16
Draft genome sequences of 21 Salmonella enterica serovar enteritidis strains. J Bacteriol (2012) 1.15
Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS One (2011) 1.15
Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status. J Biol Chem (2008) 1.15
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease. Bioorg Med Chem (2002) 1.13
The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res (2008) 1.12
Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium. Prog Retin Eye Res (2011) 1.11
Conserved residues in the coiled-coil pocket of human immunodeficiency virus type 1 gp41 are essential for viral replication and interhelical interaction. Virology (2004) 1.11
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. J Med Chem (2007) 1.11
OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Cell (2002) 1.11
Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila) (2010) 1.11
Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. J Biol Chem (2006) 1.10
Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation. Stem Cells (2012) 1.08
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. J Med Chem (2007) 1.06
Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate. J Biol Chem (2010) 1.06
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem (2005) 1.04
In vitro selection and characterization of influenza A (A/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675. J Virol (2002) 1.04
Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Carcinogenesis (2012) 1.03
Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules. PLoS One (2009) 1.02
The antitumor activity of the fungicide ciclopirox. Int J Cancer (2010) 1.02
Caries in preschool children and its risk factors in 2 provinces in China. Quintessence Int (2007) 1.02
Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. PLoS One (2010) 1.02
Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy. Am J Pathol (2009) 1.01
Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila) (2010) 1.01
Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs. Anticancer Res (2005) 1.00
Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol Cancer (2010) 0.99
Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res (Phila) (2012) 0.99
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors. Bioorg Med Chem (2006) 0.99
Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther (2006) 0.99
Resveratrol-mediated gamma interferon reduction prevents airway inflammation and airway hyperresponsiveness in respiratory syncytial virus-infected immunocompromised mice. J Virol (2011) 0.99
Genome sequences of five Salmonella enterica serovar Heidelberg isolates associated with a 2011 multistate outbreak in the United States. J Bacteriol (2012) 0.98
Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers. J Clin Psychopharmacol (2007) 0.97
Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A. J Biol Chem (2011) 0.97
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett (2008) 0.97
Adenosine-containing molecules amplify glucose signaling and enhance txnip expression. Mol Endocrinol (2009) 0.95
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Mol Cancer Ther (2006) 0.95
Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia (2008) 0.95