Published in Mol Biol Cell on September 22, 2010
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol (2011) 3.17
Cdk5rap2 exposes the centrosomal root of microcephaly syndromes. Trends Cell Biol (2011) 1.53
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci (2012) 1.30
Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers. Proc Natl Acad Sci U S A (2012) 1.12
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C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis. Cell Cycle (2012) 0.95
SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress. Nat Commun (2013) 0.92
Centrin2 regulates CP110 removal in primary cilium formation. J Cell Biol (2015) 0.87
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BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Cell Cycle (2014) 0.77
Centrosomes in the DNA damage response-the hub outside the centre. Chromosome Res (2016) 0.77
CENP-W plays a role in maintaining bipolar spindle structure. PLoS One (2014) 0.77
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification. Mol Biol Cell (2017) 0.76
Centrosomes are multifunctional regulators of genome stability. Chromosome Res (2016) 0.76
Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress. Oncotarget (2015) 0.75
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A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
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Mechanism limiting centrosome duplication to once per cell cycle. Nature (2006) 4.69
Centrosome amplification can initiate tumorigenesis in flies. Cell (2008) 4.62
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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54
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Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol (2001) 3.63
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GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. Nat Cell Biol (2005) 3.12
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Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell (2007) 2.72
Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res (2001) 2.66
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66
Centrosome duplication: of rules and licenses. Trends Cell Biol (2007) 2.51
Centrosome amplification and the development of cancer. Oncogene (2002) 2.51
"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev (2001) 2.46
The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci U S A (2000) 2.44
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. J Cell Biol (2006) 2.38
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Nat Cell Biol (2006) 2.37
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A (2007) 2.37
Centrosome number is controlled by a centrosome-intrinsic block to reduplication. Nat Cell Biol (2003) 2.33
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Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. Dev Cell (2009) 2.24
The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell (2004) 2.17
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO J (2001) 2.08
Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat Cell Biol (2000) 1.89
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
Centriole distribution during tripolar mitosis in Chinese hamster ovary cells. J Cell Biol (1984) 1.83
CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J Cell Sci (2002) 1.78
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. J Cell Biol (2005) 1.73
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Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. J Biol Chem (2001) 1.60
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J Cell Biol (2007) 1.59
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One (2007) 1.53
Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates. Oncogene (2007) 1.52
Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity. Biochemistry (2007) 1.50
Centrosomes split in the presence of impaired DNA integrity during mitosis. Mol Biol Cell (2003) 1.49
DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep (2007) 1.39
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Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci (2002) 1.36
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene (2001) 1.31
Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members. J Virol (2003) 1.31
Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. J Cell Biol (2009) 1.15
Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells. Exp Cell Res (2000) 1.10
Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2. J Cell Sci (2007) 1.06
A possible role for centrosome overduplication in radiation-induced cell death. Oncogene (2000) 1.04
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. Oncogene (2009) 1.02
Involvement of centrosome amplification in radiation-induced mitotic catastrophe. Cell Cycle (2007) 1.01
The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation. J Biol Chem (2005) 0.94
Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells. Exp Cell Res (2000) 0.94
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation. EMBO Rep (2002) 0.93
Centriole separation in DNA damage-induced centrosome amplification. Environ Mol Mutagen (2009) 0.89
Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage. Mol Cancer (2010) 0.87
DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization. Radiat Res (2003) 0.78
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell (2010) 4.11
CENP-I is essential for centromere function in vertebrate cells. Dev Cell (2002) 1.94
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol (2008) 1.54
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem (2003) 1.50
DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep (2007) 1.39
Loss of centrioles causes chromosomal instability in vertebrate somatic cells. J Cell Biol (2013) 1.28
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores. EMBO Rep (2004) 1.11
Involvement of centrosome amplification in radiation-induced mitotic catastrophe. Cell Cycle (2007) 1.01
Roles of vertebrate Smc5 in sister chromatid cohesion and homologous recombinational repair. Mol Cell Biol (2011) 1.01
The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability. FEBS Lett (2011) 0.98
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins. J Cell Biol (2011) 0.98
Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. J Cell Sci (2012) 0.96
C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis. Cell Cycle (2012) 0.95
Centriole separation in DNA damage-induced centrosome amplification. Environ Mol Mutagen (2009) 0.89
Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance. Cell Mol Life Sci (2012) 0.86
Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells. Mol Biol Cell (2009) 0.85
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity. Cell Cycle (2014) 0.85
Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair. PLoS One (2013) 0.85
Centrosome amplification in CHO and DT40 cells by inactivation of cyclin-dependent kinases. Cytoskeleton (Hoboken) (2011) 0.84
Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. Mol Biol Cell (2013) 0.83
Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells. Nucleic Acids Res (2009) 0.82
SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability. DNA Repair (Amst) (2012) 0.80
Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line. DNA Repair (Amst) (2008) 0.79
Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response. Cell Cycle (2013) 0.79
Getting permission: how DNA damage causes centrosome amplification. Cell Cycle (2011) 0.77
Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo. J Med Chem (2006) 0.76