Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

PubWeight™: 4.85‹?› | Rank: Top 1%

🔗 View Article (PMID 1766375)

Published in Mol Microbiol on August 01, 1991

Authors

G Laible1, B G Spratt, R Hakenbeck

Author Affiliations

1: Max-Planck Institut für Molekelare Genetik, Berlin, Germany.

Articles citing this

Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol (2001) 6.66

Three decades of beta-lactamase inhibitors. Clin Microbiol Rev (2010) 5.54

Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica. Proc Natl Acad Sci U S A (1994) 3.90

Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae. Infect Immun (2000) 3.30

Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae. Infect Immun (2001) 2.75

Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics. Antimicrob Agents Chemother (1996) 2.72

Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins. Antimicrob Agents Chemother (1995) 2.64

Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect Immun (1992) 2.62

Assigning strains to bacterial species via the internet. BMC Biol (2009) 2.49

Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother (1993) 2.44

Quantitative validation of media for transportation and storage of Streptococcus pneumoniae. J Clin Microbiol (2003) 2.41

Molecular detection of antimicrobial resistance. Clin Microbiol Rev (2001) 2.31

Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. J Bacteriol (1998) 2.16

Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b. J Bacteriol (1992) 2.11

Relatedness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain. EMBO J (1992) 2.06

Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 1.98

Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob Agents Chemother (1995) 1.96

Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. Proc Natl Acad Sci U S A (2000) 1.95

Molecular population genetic analysis of emerged bacterial pathogens: selected insights. Emerg Infect Dis (1996) 1.94

Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae. J Bacteriol (1991) 1.91

Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae. Antimicrob Agents Chemother (1995) 1.82

Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun (1993) 1.74

Homeologous recombination and mismatch repair during transformation in Streptococcus pneumoniae: saturation of the Hex mismatch repair system. Proc Natl Acad Sci U S A (1995) 1.73

Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother (2010) 1.72

Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (1997) 1.66

Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance. J Bacteriol (1992) 1.62

Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams. Biochem J (1993) 1.58

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob Agents Chemother (2008) 1.56

Combinational detection of autolysin and penicillin-binding protein 2B genes of Streptococcus pneumoniae by PCR. J Clin Microbiol (1996) 1.49

Role of class A penicillin-binding proteins in PBP5-mediated beta-lactam resistance in Enterococcus faecalis. J Bacteriol (2004) 1.47

Association of a thr-371 substitution in a conserved amino acid motif of penicillin-binding protein 1A with penicillin resistance of Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 1.43

Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants. J Bacteriol (1994) 1.42

Molecular epidemiology of Streptococcus pneumoniae with decreased susceptibility to penicillin in a Paris children's hospital. J Clin Microbiol (1997) 1.42

Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother (2001) 1.40

Evidence of clonal dissemination of multidrug-resistant Streptococcus pneumoniae in Hong Kong. J Clin Microbiol (1999) 1.39

Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae. J Bacteriol (1999) 1.37

Penicillin-binding proteins and bacterial resistance to beta-lactams. Antimicrob Agents Chemother (1993) 1.37

NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis. J Bacteriol (2005) 1.35

Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates. Antimicrob Agents Chemother (1999) 1.34

Subdivision of Burkholderia pseudomallei ribotypes into multiple types by random amplified polymorphic DNA analysis provides new insights into epidemiology. J Clin Microbiol (1995) 1.32

Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother (2002) 1.32

Use of biotinylated beta-lactams and chemiluminescence for study and purification of penicillin-binding proteins in bacteria. Antimicrob Agents Chemother (1994) 1.29

Synthesis, purification and kinetic properties of fluorescein-labelled penicillins. Biochem J (1994) 1.28

Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus. Biochem J (1994) 1.28

Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria. Proc Natl Acad Sci U S A (1998) 1.27

Genetics of oxacillin resistance in clinical isolates of Streptococcus pneumoniae that are oxacillin resistant and penicillin susceptible. Antimicrob Agents Chemother (1994) 1.25

Overproduction of a penicillin-binding protein is not the only mechanism of penicillin resistance in Enterococcus faecium. Antimicrob Agents Chemother (1992) 1.24

Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. J Clin Microbiol (1999) 1.24

Dissemination of high-level penicillin-, extended-spectrum cephalosporin-, and erythromycin-resistant Streptococcus pneumoniae clones in Taiwan. J Clin Microbiol (1999) 1.21

Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to beta-lactam antibiotics. J Bacteriol (1997) 1.19

Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae. Emerg Infect Dis (2000) 1.17

Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae. Infect Immun (1995) 1.16

Molecular evolution in a multidrug-resistant lineage of Streptococcus pneumoniae: emergence of strains belonging to the serotype 6B Icelandic clone that lost antibiotic resistance traits. J Clin Microbiol (2000) 1.16

In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (2008) 1.16

Identification, purification, and characterization of transpeptidase and glycosyltransferase domains of Streptococcus pneumoniae penicillin-binding protein 1a. J Bacteriol (1998) 1.14

Genotypic survey of recent beta-lactam-resistant pneumococcal nasopharyngeal isolates from asymptomatic children in Chile. J Clin Microbiol (1999) 1.14

Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother (2002) 1.07

Rapid screening for penicillin susceptibility of systemic pneumococcal isolates by restriction enzyme profiling of the pbp2B gene. J Clin Microbiol (1998) 1.07

Glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae is membrane associated. J Bacteriol (1999) 1.05

Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria. J Clin Microbiol (1999) 1.04

A mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604. Antimicrob Agents Chemother (1997) 1.04

Determination of penicillin susceptibility of Streptococcus pneumoniae using the polymerase chain reaction. Mol Pathol (1997) 1.02

In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae. Antimicrob Agents Chemother (2005) 0.99

Use of penicillin MICs to predict in vitro activity of other beta-lactam antimicrobial agents against Streptococcus pneumoniae. J Clin Microbiol (2001) 0.99

New Streptococcus pneumoniae clones in deceased wild chimpanzees. J Bacteriol (2007) 0.99

Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae. J Bacteriol (2003) 0.98

Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x. Antimicrob Agents Chemother (2006) 0.98

An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338. Antimicrob Agents Chemother (2008) 0.97

Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002. Antimicrob Agents Chemother (2004) 0.97

Horizontal gene transfer of ftsI, encoding penicillin-binding protein 3, in Haemophilus influenzae. Antimicrob Agents Chemother (2007) 0.97

Clonal and temporal patterns of nasopharyngeal penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae stains in children attending a day care center. J Clin Microbiol (1996) 0.97

Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility. Antimicrob Agents Chemother (2001) 0.94

Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics. Antimicrob Agents Chemother (2000) 0.94

Amino acid mutations essential to production of an altered PBP 2X conferring high-level beta-lactam resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother (2005) 0.94

Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. Antimicrob Agents Chemother (2007) 0.90

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae. MBio (2016) 0.88

The insertion site of the temperate phage HB-746 is located near the phage remnant in the pneumococcal host chromosome. J Virol (1992) 0.88

Application of pbp1A PCR in identification of penicillin-resistant Streptococcus pneumoniae. J Clin Microbiol (1999) 0.87

Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. Antimicrob Agents Chemother (2004) 0.87

Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Antimicrob Agents Chemother (2009) 0.87

Phenotypic and molecular analysis of penicillin-nonsusceptible Streptococcus pneumoniae isolates in Poland. Antimicrob Agents Chemother (2006) 0.86

Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother (2005) 0.86

Very low cefotaxime concentrations select for hypermutable Streptococcus pneumoniae populations. Antimicrob Agents Chemother (2002) 0.85

Molecular characterization of non-penicillin-susceptible Streptococcus pneumoniae in Norway. J Clin Microbiol (2006) 0.85

An outbreak of penicillin resistant Streptococcus pneumoniae investigated by a polymerase chain reaction based genotyping method. J Clin Pathol (1997) 0.84

Penicillin susceptibility and epidemiological typing of invasive pneumococcal isolates in the Republic of Ireland. J Clin Microbiol (2003) 0.84

Commensal streptococci serve as a reservoir for β-lactam resistance genes in Streptococcus pneumoniae. Antimicrob Agents Chemother (2015) 0.83

All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis. Antimicrob Agents Chemother (2001) 0.81

Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline. Antimicrob Agents Chemother (2012) 0.80

Rapid identification of penicillin and macrolide resistance genes and simultaneous quantification of Streptococcus pneumoniae in purulent sputum samples by use of a novel real-time multiplex PCR assay. J Clin Microbiol (2008) 0.79

Comparative antipneumococcal activities of sulopenem and other drugs. Antimicrob Agents Chemother (2009) 0.78

Detecting key structural features within highly recombined genes. PLoS Comput Biol (2007) 0.77

New aspects of the interplay between penicillin binding proteins, murM and the two component system CiaRH of penicillin-resistant Streptococcus pneumoniae serotype 19A isolates from Hungary. Antimicrob Agents Chemother (2017) 0.75

Articles by these authors

Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A (1998) 39.20

Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol (2000) 34.08

How clonal are bacteria? Proc Natl Acad Sci U S A (1993) 18.19

Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A (1975) 18.13

A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology (1998) 17.05

Properties of the penicillin-binding proteins of Escherichia coli K12,. Eur J Biochem (1977) 16.26

Penicillin-binding proteins and cell shape in E. coli. Nature (1975) 10.20

Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86

Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9. Gene (1986) 7.97

Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences. Proc Natl Acad Sci U S A (2001) 7.90

Multilocus sequence typing. Trends Microbiol (1999) 7.00

Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis (1991) 6.69

Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol (2001) 6.66

Versatile low-copy-number plasmid vectors for cloning in Escherichia coli. Gene (1982) 6.62

The relative contributions of recombination and mutation to the divergence of clones of Neisseria meningitidis. Mol Biol Evol (1999) 6.23

Localized sex in bacteria. Nature (1991) 6.03

Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1989) 5.65

Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. Mol Microbiol (1991) 5.45

Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone. Infect Immun (2001) 5.27

Recombination and the population structures of bacterial pathogens. Annu Rev Microbiol (2001) 5.14

Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae. Mol Microbiol (1998) 5.12

Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (1980) 5.12

Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology (1995) 4.93

Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae. Mol Microbiol (1989) 4.78

Temperature-sensitive cell division mutants of Escherichia coli with thermolabile penicillin-binding proteins. J Bacteriol (1977) 4.78

Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data. Genetics (2000) 4.61

Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother (1977) 4.45

Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species. Mol Microbiol (1997) 3.83

A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae. Nucleic Acids Res (1992) 3.73

Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol (1992) 3.58

Retracted A link between virulence and ecological abundance in natural populations of Staphylococcus aureus. Science (2001) 3.44

Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture. J Gen Microbiol (1983) 3.41

Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequence typing. J Clin Microbiol (1998) 3.36

Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol (1994) 3.12

X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nat Struct Biol (1996) 3.09

Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics. Trends Microbiol (1994) 2.99

Lysis of Escherichia coli by beta-lactam antibiotics: deletion analysis of the role of penicillin-binding proteins 1A and 1B. J Gen Microbiol (1985) 2.93

Escherichia coli resistance to beta-lactam antibiotics through a decrease in the affinity of a target for lethality. Nature (1978) 2.92

Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges. J Bacteriol (1997) 2.86

Identification of the major penicillin-binding proteins of Escherichia coli as D-alanine carboxypeptidase IA. J Bacteriol (1976) 2.85

Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. J Biol Chem (1986) 2.84

Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1990) 2.82

Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community. Microb Drug Resist (1995) 2.75

Penicillin-binding proteins of penicillin-susceptible and -resistant pneumococci: immunological relatedness of altered proteins and changes in peptides carrying the beta-lactam binding site. Antimicrob Agents Chemother (1986) 2.72

Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics. Antimicrob Agents Chemother (1996) 2.72

The mechanism of action of mecillinam. J Antimicrob Chemother (1977) 2.68

Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins. Antimicrob Agents Chemother (1995) 2.64

Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect Immun (1992) 2.62

The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain. J Clin Microbiol (1999) 2.56

Mutants of Escherichia coli which lack a component of penicillin-binding protein 1 are viable. FEBS Lett (1977) 2.56

The plasmid of Salmonella typhimurium LT2. Mol Gen Genet (1973) 2.54

Defective and plaque-forming lambda transducing bacteriophage carrying penicillin-binding protein-cell shape genes: genetic and physical mapping and identification of gene products from the lip-dacA-rodA-pbpA-leuS region of the Escherichia coli chromosome. J Bacteriol (1980) 2.51

Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506. Mol Microbiol (1989) 2.50

Database-driven multi locus sequence typing (MLST) of bacterial pathogens. Bioinformatics (2001) 2.45

Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother (1993) 2.44

Secretion of lipids induced by inhibition of peptidoglycan synthesis in streptococci. J Bacteriol (1977) 2.31

In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother (1980) 2.29

Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene. Mol Biol Evol (1999) 2.26

A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol Microbiol (1994) 2.22

A vector for the construction of translational fusions to TEM beta-lactamase and the analysis of protein export signals and membrane protein topology. Gene (1986) 2.21

Activity of murein hydrolases in synchronized cultures of Escherichia coli. J Bacteriol (1977) 2.16

The nucleotide sequences of the ponA and ponB genes encoding penicillin-binding protein 1A and 1B of Escherichia coli K12. Eur J Biochem (1985) 2.14

Estimating the relative contributions of mutation and recombination to clonal diversification: a comparison between Neisseria meningitidis and Streptococcus pneumoniae. Res Microbiol (2000) 2.14

Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b. J Bacteriol (1992) 2.11

Biochemical and genetical approaches to the mechanism of action of penicillin. Philos Trans R Soc Lond B Biol Sci (1980) 2.11

Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species. Mol Biol Evol (1999) 2.10

Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation. J Bacteriol (1994) 2.10

Deletion of the penicillin-binding protein 6 gene of Escherichia coli. J Bacteriol (1982) 2.10

Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol (1989) 2.09

The balance between different peptidoglycan precursors determines whether Escherichia coli cells will elongate or divide. J Bacteriol (1990) 2.07

Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region. Microbiology (1999) 2.07

Relatedness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain. EMBO J (1992) 2.06

Spherical E. coli due to elevated levels of D-alanine carboxypeptidase. Nature (1982) 2.02

Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol (1990) 1.97

Interaction of the pneumococcal amidase with lipoteichoic acid and choline. Eur J Biochem (1985) 1.97

Meningococcal conjugate vaccines: new opportunities and new challenges. Lancet (1999) 1.93

Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae. J Bacteriol (1991) 1.91

Comparison of the binding properties of two 6 beta-amidinopenicillanic acid derivatives that differ in their physiological effects on Escherichia coli. Antimicrob Agents Chemother (1977) 1.91

Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res (1989) 1.91

Sequence diversity within the argF, fbp and recA genes of natural isolates of Neisseria meningitidis: interspecies recombination within the argF gene. Mol Microbiol (1992) 1.90

Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli. J Bacteriol (1986) 1.89

The Streptococcus pneumoniae beta-galactosidase is a surface protein. J Bacteriol (2000) 1.89

Identification of the major Spanish clones of penicillin-resistant pneumococci via the Internet using multilocus sequence typing. J Clin Microbiol (2000) 1.88

Resistance to beta-lactam antibiotics by re-modelling the active site of an E. coli penicillin-binding protein. Nature (1986) 1.87

Opa-typing: a high-resolution tool for studying the epidemiology of gonorrhoea. Mol Microbiol (1995) 1.86

WebACT--an online companion for the Artemis Comparison Tool. Bioinformatics (2005) 1.78

Precursor forms of penicillin-binding proteins 5 and 6 of E. coli cytoplasmic membrane. Nature (1981) 1.76

Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun (1993) 1.74

Homeologous recombination and mismatch repair during transformation in Streptococcus pneumoniae: saturation of the Hex mismatch repair system. Proc Natl Acad Sci U S A (1995) 1.73

Membrane topology of penicillin-binding protein 3 of Escherichia coli. Mol Microbiol (1989) 1.70

Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F. Microbiology (1996) 1.69

Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol Microbiol (1994) 1.66

Production of thiol-penicillin-binding protein 3 of Escherichia coli using a two primer method of site-directed mutagenesis. EMBO J (1985) 1.65

A comparison of the nucleotide sequences of the adk and recA genes of pathogenic and commensal Neisseria species: evidence for extensive interspecies recombination within adk. J Mol Evol (1996) 1.65

Sequence evolution of the porB gene of Neisseria gonorrhoeae and Neisseria meningitidis: evidence of positive Darwinian selection. Mol Biol Evol (1995) 1.65

Deletion of the penicillin-binding protein 5 gene of Escherichia coli. J Bacteriol (1980) 1.63

Retracted Directional gene movement from human-pathogenic to commensal-like streptococci. Infect Immun (2001) 1.61