Published in Mol Microbiol on January 01, 1989
Pneumococcal resistance to antibiotics. Clin Microbiol Rev (1990) 9.76
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1989) 5.65
Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis. Proc Natl Acad Sci U S A (1989) 3.22
Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1990) 2.82
Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics. Antimicrob Agents Chemother (1996) 2.72
BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins. Antimicrob Agents Chemother (1999) 2.69
Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother (1993) 2.44
A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci. Proc Natl Acad Sci U S A (1990) 2.18
Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. J Bacteriol (1998) 2.16
Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b. J Bacteriol (1992) 2.11
Relatedness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain. EMBO J (1992) 2.06
Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother (2002) 2.05
Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 1.98
Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob Agents Chemother (1995) 1.96
Molecular population genetic analysis of emerged bacterial pathogens: selected insights. Emerg Infect Dis (1996) 1.94
Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae. J Bacteriol (1991) 1.91
Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res (1989) 1.91
Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae. Antimicrob Agents Chemother (1995) 1.82
Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun (1993) 1.74
Homeologous recombination and mismatch repair during transformation in Streptococcus pneumoniae: saturation of the Hex mismatch repair system. Proc Natl Acad Sci U S A (1995) 1.73
The Enterococcus hirae R40 penicillin-binding protein 5 and the methicillin-resistant Staphylococcus aureus penicillin-binding protein 2' are similar. Biochem J (1991) 1.70
Association of a thr-371 substitution in a conserved amino acid motif of penicillin-binding protein 1A with penicillin resistance of Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 1.43
Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants. J Bacteriol (1994) 1.42
Molecular epidemiology of Streptococcus pneumoniae with decreased susceptibility to penicillin in a Paris children's hospital. J Clin Microbiol (1997) 1.42
Naturally occurring peptidoglycan variants of Streptococcus pneumoniae. J Bacteriol (1996) 1.41
Molecular characterization of pneumococcal nasopharynx isolates collected from children during their first 2 years of life. J Clin Microbiol (1998) 1.40
Evidence of clonal dissemination of multidrug-resistant Streptococcus pneumoniae in Hong Kong. J Clin Microbiol (1999) 1.39
Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae isolates recovered in Italy from 1993 to 1996. J Clin Microbiol (1998) 1.38
Penicillin-binding proteins and bacterial resistance to beta-lactams. Antimicrob Agents Chemother (1993) 1.37
NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis. J Bacteriol (2005) 1.35
Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates. Antimicrob Agents Chemother (1999) 1.34
Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin. Antimicrob Agents Chemother (1999) 1.29
Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus. Biochem J (1994) 1.28
Genetics of oxacillin resistance in clinical isolates of Streptococcus pneumoniae that are oxacillin resistant and penicillin susceptible. Antimicrob Agents Chemother (1994) 1.25
Overproduction of a penicillin-binding protein is not the only mechanism of penicillin resistance in Enterococcus faecium. Antimicrob Agents Chemother (1992) 1.24
Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin. Antimicrob Agents Chemother (2002) 1.16
Multidrug-resistant Streptococcus pneumoniae in Poland: identification of emerging clones. J Clin Microbiol (1999) 1.15
Genotypic survey of recent beta-lactam-resistant pneumococcal nasopharyngeal isolates from asymptomatic children in Chile. J Clin Microbiol (1999) 1.14
Rapid screening for penicillin susceptibility of systemic pneumococcal isolates by restriction enzyme profiling of the pbp2B gene. J Clin Microbiol (1998) 1.07
Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother (2002) 1.07
Glycosyltransferase domain of penicillin-binding protein 2a from Streptococcus pneumoniae is membrane associated. J Bacteriol (1999) 1.05
Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother (1996) 1.05
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates from Bulgaria. J Clin Microbiol (1999) 1.04
Determination of penicillin susceptibility of Streptococcus pneumoniae using the polymerase chain reaction. Mol Pathol (1997) 1.02
Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae. J Bacteriol (2003) 0.98
Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance. Antimicrob Agents Chemother (2004) 0.98
Purification and partial characterization of a penicillin-binding protein from Mycobacterium smegmatis. J Bacteriol (1992) 0.97
Genetic relatedness within serotypes of penicillin-susceptible Streptococcus pneumoniae isolates. J Clin Microbiol (2000) 0.96
An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci. Antimicrob Agents Chemother (2004) 0.95
Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics. Antimicrob Agents Chemother (2000) 0.94
Molecular epidemiology of penicillin-nonsusceptible Streptococcus pneumoniae among children in Greece. J Clin Microbiol (2000) 0.92
Nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae among children with acute respiratory tract infections in Thailand: a molecular epidemiological survey. J Clin Microbiol (1999) 0.90
Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. Antimicrob Agents Chemother (2007) 0.90
Clonal distribution of penicillin-resistant Streptococcus pneumoniae 23F in France. J Clin Microbiol (1996) 0.87
Penicillin susceptibility and epidemiological typing of invasive pneumococcal isolates in the Republic of Ireland. J Clin Microbiol (2003) 0.84
Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective. Clin Microbiol Rev (2016) 0.82
The 2011 Garrod Lecture: From penicillin-binding proteins to molecular epidemiology. J Antimicrob Chemother (2012) 0.82
All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis. Antimicrob Agents Chemother (2001) 0.81
Cloning and expression of the ponB gene, encoding penicillin-binding protein 1B of Escherichia coli, in heterologous systems. J Bacteriol (1990) 0.79
In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study. Antimicrob Agents Chemother (2002) 0.75
Point mutations of two arginine residues in the Streptomyces R61 DD-peptidase. Biochem J (1992) 0.75
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A (1998) 39.20
Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol (2000) 34.08
How clonal are bacteria? Proc Natl Acad Sci U S A (1993) 18.19
Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A (1975) 18.13
A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology (1998) 17.05
Properties of the penicillin-binding proteins of Escherichia coli K12,. Eur J Biochem (1977) 16.26
Penicillin-binding proteins and cell shape in E. coli. Nature (1975) 10.20
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9. Gene (1986) 7.97
Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences. Proc Natl Acad Sci U S A (2001) 7.90
Multilocus sequence typing. Trends Microbiol (1999) 7.00
Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis (1991) 6.69
Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol (2001) 6.66
Versatile low-copy-number plasmid vectors for cloning in Escherichia coli. Gene (1982) 6.62
The relative contributions of recombination and mutation to the divergence of clones of Neisseria meningitidis. Mol Biol Evol (1999) 6.23
Localized sex in bacteria. Nature (1991) 6.03
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1989) 5.65
Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. Mol Microbiol (1991) 5.45
Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone. Infect Immun (2001) 5.27
Recombination and the population structures of bacterial pathogens. Annu Rev Microbiol (2001) 5.14
Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae. Mol Microbiol (1998) 5.12
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology (1995) 4.93
Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Mol Microbiol (1991) 4.85
Temperature-sensitive cell division mutants of Escherichia coli with thermolabile penicillin-binding proteins. J Bacteriol (1977) 4.78
Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data. Genetics (2000) 4.61
Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother (1977) 4.45
Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species. Mol Microbiol (1997) 3.83
Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol (1992) 3.58
Retracted A link between virulence and ecological abundance in natural populations of Staphylococcus aureus. Science (2001) 3.44
Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture. J Gen Microbiol (1983) 3.41
How sensitive are immunometric assays for thyrotropin? Clin Chem (1989) 3.39
Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequence typing. J Clin Microbiol (1998) 3.36
Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis. Proc Natl Acad Sci U S A (1989) 3.22
Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol (1994) 3.12
Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics. Trends Microbiol (1994) 2.99
Lysis of Escherichia coli by beta-lactam antibiotics: deletion analysis of the role of penicillin-binding proteins 1A and 1B. J Gen Microbiol (1985) 2.93
Escherichia coli resistance to beta-lactam antibiotics through a decrease in the affinity of a target for lethality. Nature (1978) 2.92
Identification of the major penicillin-binding proteins of Escherichia coli as D-alanine carboxypeptidase IA. J Bacteriol (1976) 2.85
Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. J Biol Chem (1986) 2.84
Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1990) 2.82
The mechanism of action of mecillinam. J Antimicrob Chemother (1977) 2.68
Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins. Antimicrob Agents Chemother (1995) 2.64
The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain. J Clin Microbiol (1999) 2.56
Mutants of Escherichia coli which lack a component of penicillin-binding protein 1 are viable. FEBS Lett (1977) 2.56
The plasmid of Salmonella typhimurium LT2. Mol Gen Genet (1973) 2.54
Database-driven multi locus sequence typing (MLST) of bacterial pathogens. Bioinformatics (2001) 2.45
Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother (1993) 2.44
Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene. Mol Biol Evol (1999) 2.26
A vector for the construction of translational fusions to TEM beta-lactamase and the analysis of protein export signals and membrane protein topology. Gene (1986) 2.21
Sequence analysis of ARS elements in fission yeast. EMBO J (1988) 2.17
The nucleotide sequences of the ponA and ponB genes encoding penicillin-binding protein 1A and 1B of Escherichia coli K12. Eur J Biochem (1985) 2.14
Estimating the relative contributions of mutation and recombination to clonal diversification: a comparison between Neisseria meningitidis and Streptococcus pneumoniae. Res Microbiol (2000) 2.14
Biochemical and genetical approaches to the mechanism of action of penicillin. Philos Trans R Soc Lond B Biol Sci (1980) 2.11
Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species. Mol Biol Evol (1999) 2.10
Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation. J Bacteriol (1994) 2.10
Deletion of the penicillin-binding protein 6 gene of Escherichia coli. J Bacteriol (1982) 2.10
Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol (1989) 2.09
The balance between different peptidoglycan precursors determines whether Escherichia coli cells will elongate or divide. J Bacteriol (1990) 2.07
Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region. Microbiology (1999) 2.07
Spherical E. coli due to elevated levels of D-alanine carboxypeptidase. Nature (1982) 2.02
Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol (1990) 1.97
Meningococcal conjugate vaccines: new opportunities and new challenges. Lancet (1999) 1.93
Comparison of the binding properties of two 6 beta-amidinopenicillanic acid derivatives that differ in their physiological effects on Escherichia coli. Antimicrob Agents Chemother (1977) 1.91
Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res (1989) 1.91
Sequence diversity within the argF, fbp and recA genes of natural isolates of Neisseria meningitidis: interspecies recombination within the argF gene. Mol Microbiol (1992) 1.90
Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli. J Bacteriol (1986) 1.89
Identification of the major Spanish clones of penicillin-resistant pneumococci via the Internet using multilocus sequence typing. J Clin Microbiol (2000) 1.88
Resistance to beta-lactam antibiotics by re-modelling the active site of an E. coli penicillin-binding protein. Nature (1986) 1.87
Opa-typing: a high-resolution tool for studying the epidemiology of gonorrhoea. Mol Microbiol (1995) 1.86
WebACT--an online companion for the Artemis Comparison Tool. Bioinformatics (2005) 1.78
Precursor forms of penicillin-binding proteins 5 and 6 of E. coli cytoplasmic membrane. Nature (1981) 1.76
Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun (1993) 1.74
Membrane topology of penicillin-binding protein 3 of Escherichia coli. Mol Microbiol (1989) 1.70
Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F. Microbiology (1996) 1.69
Production of thiol-penicillin-binding protein 3 of Escherichia coli using a two primer method of site-directed mutagenesis. EMBO J (1985) 1.65
A comparison of the nucleotide sequences of the adk and recA genes of pathogenic and commensal Neisseria species: evidence for extensive interspecies recombination within adk. J Mol Evol (1996) 1.65
Sequence evolution of the porB gene of Neisseria gonorrhoeae and Neisseria meningitidis: evidence of positive Darwinian selection. Mol Biol Evol (1995) 1.65
Deletion of the penicillin-binding protein 5 gene of Escherichia coli. J Bacteriol (1980) 1.63
Retracted Directional gene movement from human-pathogenic to commensal-like streptococci. Infect Immun (2001) 1.61
Genetics and molecular biology of beta-lactam-resistant pneumococci. Microb Drug Resist (1995) 1.61
Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochem J (1991) 1.57
A mecillinam-sensitive peptidoglycan crosslinking reaction in Escherichia coli. Biochem Biophys Res Commun (1982) 1.56
Deletion analysis of the essentiality of penicillin-binding proteins 1A, 2B and 2X of Streptococcus pneumoniae. FEMS Microbiol Lett (1993) 1.55
Organization and subcloning of the dacA-rodA-pbpA cluster of cell shape genes in Escherichia coli. J Bacteriol (1983) 1.54
Identification of the rodA gene product of Escherichia coli. J Bacteriol (1983) 1.54
Amino acid substitutions that reduce the affinity of penicillin-binding protein 3 of Escherichia coli for cephalexin. Eur J Biochem (1985) 1.49
Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae. Microb Drug Resist (1998) 1.49
Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination. Proc Natl Acad Sci U S A (1995) 1.48
Dynamics of penicillin-susceptible clones in invasive pneumococcal disease. J Infect Dis (2001) 1.47
Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA. Antimicrob Agents Chemother (1990) 1.44
Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa. Eur J Clin Microbiol Infect Dis (1994) 1.42
Monofunctional biosynthetic peptidoglycan transglycosylases. Mol Microbiol (1996) 1.39
A gene fusion that localises the penicillin-binding domain of penicillin-binding protein 3 of Escherichia coli. FEBS Lett (1984) 1.35
Penicillin-resistant isolates of Neisseria lactamica produce altered forms of penicillin-binding protein 2 that arose by interspecies horizontal gene transfer. Antimicrob Agents Chemother (1991) 1.32
Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli. Nucleic Acids Res (1988) 1.32
Ecological separation and genetic isolation of Neisseria gonorrhoeae and Neisseria meningitidis. Curr Biol (1993) 1.26