Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMC 2758575)

Published in Am J Physiol Renal Physiol on August 01, 2007

Authors

G Chen1, E A Bridenbaugh, A D Akintola, J M Catania, V S Vaidya, J V Bonventre, A C Dearman, H W Sampson, D C Zawieja, R C Burghardt, A R Parrish

Author Affiliations

1: Department of Systems Biology and Translational Medicine, College of Medicine, Texas A&M University System Health Science Center, College Station, TX 77843-1114, USA.

Articles citing this

Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci (2008) 2.98

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med (2013) 2.28

Pathophysiology of acute kidney injury. Compr Physiol (2012) 1.56

Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation. Am J Pathol (2010) 1.34

Zag expression during aging suppresses proliferation after kidney injury. J Am Soc Nephrol (2008) 1.25

SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep (2013) 1.17

Secreted klotho and chronic kidney disease. Adv Exp Med Biol (2012) 1.13

Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury. PLoS One (2013) 0.99

The aging kidney: increased susceptibility to nephrotoxicity. Int J Mol Sci (2014) 0.92

Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Biochim Biophys Acta (2011) 0.91

Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria. Biochem J (2010) 0.86

Protective effect of Lifor solution in experimental renal ischemia-reperfusion injury. J Surg Res (2010) 0.85

Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. Am J Nephrol (2012) 0.85

Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience (2010) 0.84

Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. Infect Immun (2010) 0.83

Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains. J Cell Mol Med (2010) 0.82

Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Physiol Rep (2013) 0.80

Resveratrol attenuates renal injury and fibrosis by inhibiting transforming growth factor-β pathway on matrix metalloproteinase 7. Exp Biol Med (Maywood) (2015) 0.80

Growth and development alter susceptibility to acute renal injury. Kidney Int (2008) 0.79

Life cycle analysis of kidney gene expression in male F344 rats. PLoS One (2013) 0.78

The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int (2017) 0.77

Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells. BMC Complement Altern Med (2015) 0.75

Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury. Int J Mol Sci (2017) 0.75

An Intracellular Matrix Metalloproteinase-2 Isoform Induces Tubular Regulated Necrosis: Implications for Acute Kidney Injury. Am J Physiol Renal Physiol (2017) 0.75

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int (2002) 8.03

Hospital-acquired renal insufficiency. Am J Kidney Dis (2002) 7.90

Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol (2006) 6.86

Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol (2006) 6.66

Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem (1998) 5.99

Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation (2002) 4.99

Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell (2002) 4.89

Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int (1996) 4.28

Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol (2005) 3.94

A transcriptional profile of aging in the human kidney. PLoS Biol (2004) 3.69

Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol (2003) 3.61

Differential gene expression following early renal ischemia/reperfusion. Kidney Int (2003) 2.60

Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol (2003) 2.12

Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol (2006) 1.85

Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med (1996) 1.74

The aging kidney: insights from experimental studies. J Am Soc Nephrol (1998) 1.61

The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell (1995) 1.60

Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest (1994) 1.49

Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol (2006) 1.47

Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol (2006) 1.36

Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling. Kidney Int (2005) 1.31

Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study. Arch Intern Med (1990) 1.23

Incidence and prognosis of acute renal failure in older patients. J Am Geriatr Soc (1990) 1.20

The aging kidney: a review -- part I. Int Urol Nephrol (2005) 1.20

Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int (2004) 1.18

Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity. Toxicol Sci (2004) 1.02

The aging kidney: a review--part II. Int Urol Nephrol (2005) 0.96

Suppression of apoptosis by calorie restriction in aged kidney. Exp Gerontol (2004) 0.95

Calorie restriction in obesity: prevention of kidney disease in rodents. J Nutr (2001) 0.94

Functional versus structural changes in the pathophysiology of acute ischemic renal failure in aging rats. Kidney Int (1994) 0.91

Age-related differences in susceptibility to renal ischemia in rats. Toxicol Appl Pharmacol (1987) 0.88

Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases. J Gerontol A Biol Sci Med Sci (2005) 0.87

Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction. Free Radic Res (2005) 0.85

Effects of aging on expression of ischemic acute renal failure in rats. Lab Invest (1989) 0.85

Concerted action of the renin-angiotensin system, mitochondria, and antioxidant defenses in aging. Mol Aspects Med (2004) 0.84

Age-related increased susceptibility of male Fischer 344 rats to acetaminophen nephrotoxicity. Life Sci (1986) 0.83

The aging male rat: structure and function of the kidney. Am J Anat (1983) 0.82

Gene expression in aging kidney and pituitary. Biogerontology (2004) 0.82

Urine-concentrating ability in the aging kidney. Sci Aging Knowledge Environ (2003) 0.81

The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. Int Urol Nephrol (2001) 0.80

cDNA representational difference analysis used in the identification of genes related to the aging process in rat kidney. Mech Ageing Dev (2005) 0.80

Experimental study showing a diminished cytosolic antioxidative capacity in kidneys of aged rats. Urol Int (2000) 0.78

Influence of age and vitamin E on post-ischemic acute renal failure. Exp Gerontol (2004) 0.78

Concerns about KIM-1 as a urinary biomarker for acute tubular necrosis (ATN). Kidney Int (2003) 0.78

Articles by these authors

Acute renal failure. N Engl J Med (1996) 8.83

Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem (1998) 5.99

Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature (2001) 4.82

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest (1994) 4.01

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest (1996) 3.73

Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int (2007) 3.23

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A (1992) 3.01

Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int (2007) 2.86

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci U S A (1996) 2.54

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci U S A (1994) 2.46

Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci U S A (1994) 2.26

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A (1999) 2.16

Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. Am J Physiol (1989) 2.07

Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A (2001) 1.98

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem (1994) 1.84

Role of matrix metalloproteinases in renal pathophysiologies. Am J Physiol Renal Physiol (2006) 1.79

Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem (2001) 1.77

Calcium measurement in isolated arterioles during myogenic and agonist stimulation. Am J Physiol (1991) 1.75

Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Mol Med (1996) 1.71

Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation. J Biol Chem (2000) 1.66

Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephrol Hypertens (2000) 1.64

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy. J Clin Invest (1998) 1.64

Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells. J Biol Chem (1988) 1.56

Calcium and ischemic injury. N Engl J Med (1986) 1.54

Poly[allylamine hydrochloride] (RenaGel): a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure. Am J Kidney Dis (1997) 1.48

Evidence for genetic factors in the development and progression of IgA nephropathy. Kidney Int (2000) 1.47

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress. J Biol Chem (2000) 1.46

Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int (2007) 1.46

Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol Cell Biol (1993) 1.44

Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proc Natl Acad Sci U S A (1999) 1.41

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade. Am J Physiol (1993) 1.41

Acute renal failure in the intensive care unit. Part 2. Intensive Care Med (1988) 1.39

Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol (1998) 1.38

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol (1999) 1.38

Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J (1996) 1.36

Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice. J Clin Invest (1990) 1.35

Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations. Biochem J (1990) 1.31

Stress-activated protein kinases in cardiovascular disease. Circ Res (1996) 1.30

Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells. Am J Physiol (1986) 1.28

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J Biol Chem (2000) 1.27

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem (1993) 1.26

Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol Reprod (2000) 1.26

Role of CD11a and CD11b in ischemic acute renal failure in rats. Am J Physiol (1994) 1.24

Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation. Reproduction (2002) 1.24

Flow modulates coronary venular permeability by a nitric oxide-related mechanism. Am J Physiol (1992) 1.24

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J (2001) 1.22

Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. Biochim Biophys Acta (2000) 1.22

Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia. Am J Physiol (1999) 1.22

Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells. J Biol Chem (1993) 1.20

Enzymatic characteristics of the c-Raf-1 protein kinase. Proc Natl Acad Sci U S A (1994) 1.19

A role for oxygen free radicals in aminonucleoside nephrosis. Kidney Int (1986) 1.18

Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A (2001) 1.17

Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun (1995) 1.17

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells. J Biol Chem (1991) 1.16

Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibody. Kidney Int (1999) 1.14

Rat ovarian granulosa cell culture: a model system for the study of cell-cell communication during multistep transformation. Cancer Res (1991) 1.13

Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage. J Biol Chem (1986) 1.10

Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells. Toxicol Appl Pharmacol (2003) 1.10

An ultrastructural investigation of calcium-dependent granules in the rat neuropil. Brain Res (1970) 1.07

Growth factors and mitogen-activated protein kinases. Hypertension (1998) 1.07

Heat shock protects cultured neurons from glutamate toxicity. Neuron (1991) 1.05

Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. Requirement for dual inputs of oxidant stress and increased cytosolic [Ca2+]. J Biol Chem (1997) 1.05

Fluorometric assay for urea in urine, plasma, and tubular fluid. Anal Biochem (1979) 1.04

Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells. J Biol Chem (1996) 1.04

Permeability to albumin in isolated coronary venules. Am J Physiol (1993) 1.04

Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo. Biol Reprod (1996) 1.03

Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. Am J Physiol (1995) 1.03

Constitutive and inducible expression of cytochrome P450IA1 and P450IB1 in human vascular endothelial and smooth muscle cells. In Vitro Cell Dev Biol Anim (1998) 1.02

Effects of metabolic acidosis on viability of cells exposed to anoxia. Am J Physiol (1985) 1.02

Tubular organization and vascular-tubular relations in the dog kidney. Am J Physiol (1975) 1.01

PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol Cell Biol (2001) 1.01

Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production. J Anim Sci (2010) 1.01

Acute renal failure in the 21st century: recommendations for management and outcomes assessment. Am J Kidney Dis (1997) 1.01

An electron microscopic localization of calcium in the small intestine of normal, rachitic, and vitamin-D-treated rats. Calcif Tissue Res (1970) 0.99

Subcellular characteristics of phospholipase A2 activity in the rat kidney. Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion. J Clin Invest (1991) 0.99

Pathophysiology of ischemic acute renal failure. Contrib Nephrol (2001) 0.99

Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells. Biochem J (1988) 0.99

Effects of verapamil in models of ischemic acute renal failure in the rat. Am J Physiol (1983) 0.98

Stretch-induced increases in intracellular calcium of isolated vascular smooth muscle cells. Am J Physiol (1992) 0.98

Fetal-maternal interactions during the establishment of pregnancy in ruminants. Soc Reprod Fertil Suppl (2007) 0.98

Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity. J Neurochem (1998) 0.98

Conceptus signals for establishment and maintenance of pregnancy. Anim Reprod Sci (2004) 0.98

Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. J Biol Chem (1991) 0.97

Membrane fusion during spermiogenesis in Ascaris. J Ultrastruct Res (1978) 0.97

Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes. J Infect Dis (2001) 0.97

Noninvasive renal diagnostic studies. Clin Lab Med (1988) 0.96

Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem (2001) 0.96

Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. J Lipid Res (2001) 0.96

Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep. Biol Reprod (2001) 0.96

Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter. J Biol Chem (1995) 0.96

Alcohol consumption by young actively growing rats: a study of cortical bone histomorphometry and mechanical properties. Alcohol Clin Exp Res (1997) 0.96

Development and characterization of immortalized ovine endometrial cell lines. Biol Reprod (1999) 0.96

Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells. J Biol Chem (1991) 0.96

WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development. Endocrinology (2007) 0.95

Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). Am J Physiol Renal Physiol (2001) 0.95

Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells. Am J Physiol (1990) 0.95

Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury. Kidney Int (1990) 0.95

Oscillations of intracellular calcium induced by vasopressin in individual fura-2-loaded mesangial cells. Frequency dependence on basal calcium concentration, agonist concentration, and temperature. J Biol Chem (1991) 0.94

Cytosolic free calcium concentration in cultured renal epithelial cells. Am J Physiol (1986) 0.94