A transcriptional profile of aging in the human kidney.

Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet (2007) 12.08

Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A (2005) 8.65

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48

Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59

Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics (2009) 3.50

Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res (2010) 2.44

Analysis of cell fate from single-cell gene expression profiles in C. elegans. Cell (2009) 2.16

Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol (2007) 2.12

Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables. Proc Natl Acad Sci U S A (2006) 1.95

Aging and gene expression in the primate brain. PLoS Biol (2005) 1.76

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol (2013) 1.69

Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. Hypertension (2008) 1.66

Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*. Methods Mol Biol (2006) 1.46

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell (2011) 1.37

Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol (2013) 1.34

Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS One (2008) 1.33

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. PLoS Genet (2009) 1.30

Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues. PLoS One (2008) 1.24

Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction. Am J Physiol Renal Physiol (2007) 1.23

Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Res (2012) 1.20

Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci (2011) 1.16

Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol (2009) 1.16

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging (Albany NY) (2015) 1.15

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet (2012) 1.14

Cross-species microarray analysis with the OSCAR system suggests an INSR->Pax6->NQO1 neuro-protective pathway in aging and Alzheimer's disease. Nucleic Acids Res (2007) 1.13

Quantitative measurement of aging using image texture entropy. Bioinformatics (2009) 1.13

Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.13

The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease. Proteomics (2009) 1.11

Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell (2010) 1.09

Systems biology of aging in four species. Curr Opin Biotechnol (2007) 1.07

Age-correlated gene expression in normal and neurodegenerative human brain tissues. PLoS One (2010) 1.06

Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer. Cancer Epidemiol Biomarkers Prev (2012) 1.03

The expression signature of in vitro senescence resembles mouse but not human aging. Genome Biol (2005) 1.03

Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles. Proc Natl Acad Sci U S A (2007) 1.02

Flies selected for longevity retain a young gene expression profile. Age (Dordr) (2010) 1.00

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R. PLoS One (2012) 0.97

A methodology for the analysis of differential coexpression across the human lifespan. BMC Bioinformatics (2009) 0.96

Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immun Ageing (2008) 0.96

Postmortem cardiac tissue maintains gene expression profile even after late harvesting. BMC Genomics (2012) 0.95

Omics technologies and the study of human ageing. Nat Rev Genet (2013) 0.95

The new science of ageing. Philos Trans R Soc Lond B Biol Sci (2011) 0.94

The aging kidney: increased susceptibility to nephrotoxicity. Int J Mol Sci (2014) 0.92

Epigenetics of aging and aging-related disease. J Gerontol A Biol Sci Med Sci (2014) 0.91

Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance. Pharmacogenomics (2009) 0.90

Discovery of molecular associations among aging, stem cells, and cancer based on gene expression profiling. Chin J Cancer (2013) 0.89

Activation of the immune response is a key feature of aging in mice. Biogerontology (2009) 0.89

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. Genome Biol (2015) 0.89

Genotype×age interaction in human transcriptional ageing. Mech Ageing Dev (2012) 0.88

Integration of 'omics' data in aging research: from biomarkers to systems biology. Aging Cell (2015) 0.88

Age-associated changes in gene expression in human brain and isolated neurons. Neurobiol Aging (2012) 0.87

Advances in urinary proteome analysis and biomarker discovery in pediatric renal disease. Pediatr Nephrol (2009) 0.87

Aging--RNA in development and disease. Wiley Interdiscip Rev RNA (2011) 0.87

Computational biology for ageing. Philos Trans R Soc Lond B Biol Sci (2011) 0.87

Toward a control theory analysis of aging. Annu Rev Biochem (2008) 0.86

A mesenchymal stromal cell gene signature for donor age. PLoS One (2012) 0.86

Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria. Biochem J (2010) 0.86

Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes. Aging (Albany NY) (2013) 0.86

Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine. PLoS One (2013) 0.85

Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase. Aging (Albany NY) (2014) 0.83

Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension? Curr Opin Cardiol (2009) 0.83

Major aging-associated RNA expressions change at two distinct age-positions. BMC Genomics (2014) 0.82

Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. Front Cell Dev Biol (2015) 0.82

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Sci Rep (2015) 0.82

Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. J Invest Dermatol (2012) 0.81

Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging. PLoS One (2014) 0.81

A subset of metzincins and related genes constitutes a marker of human solid organ fibrosis. Virchows Arch (2011) 0.81

Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Physiol Rep (2013) 0.80

The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney. PLoS Genet (2015) 0.80

Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging. BMC Genomics (2013) 0.79

Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches. J Biomed Biotechnol (2010) 0.79

The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency. Age (Dordr) (2010) 0.79

Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY) (2016) 0.79

Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice. PLoS One (2014) 0.78

Insights into aging through measurements of the Drosophila proteome as a function of temperature. Mech Ageing Dev (2010) 0.78

Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approach. Genomics Proteomics Bioinformatics (2012) 0.78

Genetics and skin aging. Dermatoendocrinol (2012) 0.78

Proteomic study on gender differences in aging kidney of mice. Proteome Sci (2009) 0.78

Life cycle analysis of kidney gene expression in male F344 rats. PLoS One (2013) 0.78

Breast Cancer beyond the Age of Mutation. Gerontology (2015) 0.78

The spatial association of gene expression evolves from synchrony to asynchrony and stochasticity with age. PLoS One (2011) 0.77

Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver. Age (Dordr) (2012) 0.77

Signatures of miR-181a on renal transcriptome and blood pressure. Mol Med (2015) 0.77

A roadmap for the genetic analysis of renal aging. Aging Cell (2015) 0.76

Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging. Nucleic Acids Res (2015) 0.76

Renal Aging: Causes and Consequences. J Am Soc Nephrol (2016) 0.75

Challenges and promise for the development of human immune monitoring. Rambam Maimonides Med J (2012) 0.75

Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLoS One (2016) 0.75

Human Lung Tissue Transcriptome: Influence of Sex and Age. PLoS One (2016) 0.75

Uncovering RNA binding proteins associated with age and gender during liver maturation. Sci Rep (2015) 0.75

Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains. PLoS One (2013) 0.75

Robust test method for time-course microarray experiments. BMC Bioinformatics (2010) 0.75

Effects of Aging on Kidney Graft Function, Oxidative Stress and Gene Expression after Kidney Transplantation. PLoS One (2013) 0.75

Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells. BMC Complement Altern Med (2015) 0.75

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors. PLoS Genet (2017) 0.75

An Intracellular Matrix Metalloproteinase-2 Isoform Induces Tubular Regulated Necrosis: Implications for Acute Kidney Injury. Am J Physiol Renal Physiol (2017) 0.75

MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. PLoS One (2017) 0.75

Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49

Why do we age? Nature (2000) 8.48

Mitotic misregulation and human aging. Science (2000) 8.47

Genomic analysis of gene expression in C. elegans. Science (2000) 8.38

Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19

Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06

Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol (2002) 5.58

Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46

Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet (2004) 4.77

Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72

ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res (2003) 3.31

Genetics and the specificity of the aging process. Science (2003) 3.20

Transcriptional profile of aging in C. elegans. Curr Biol (2002) 3.02

Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol (2003) 2.59

Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.39

Gene expression profile of aging in human muscle. Physiol Genomics (2003) 2.36

Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women. Exp Gerontol (2004) 2.00

Model organisms as a guide to mammalian aging. Dev Cell (2002) 1.96

Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell (2003) 1.79

Oxidative stress and aging. Adv Exp Med Biol (2003) 1.67

Determinants of glomerular hypofiltration in aging humans. Kidney Int (2003) 1.54

Microarray analysis of gene expression in the aging human retina. Invest Ophthalmol Vis Sci (2002) 1.38

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12

Caloric restriction, gene expression, and aging. Alzheimer Dis Assoc Disord (2003) 1.02

The structure of haplotype blocks in the human genome. Science (2002) 50.88

Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89

Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22

A gene-coexpression network for global discovery of conserved genetic modules. Science (2003) 18.75

The role of site accessibility in microRNA target recognition. Nat Genet (2007) 18.52

Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74

Long noncoding RNA as modular scaffold of histone modification complexes. Science (2010) 15.23

A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60

A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21

A high-resolution map of transcription in the yeast genome. Proc Natl Acad Sci U S A (2006) 11.81

Empirical analysis of transcriptional activity in the Arabidopsis genome. Science (2003) 11.62

The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41

Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36

Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci U S A (2004) 10.99

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78

Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A (2005) 8.65

The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (2008) 8.52

Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature (2002) 8.32

Role of duplicate genes in genetic robustness against null mutations. Nature (2003) 7.81

Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69

Multiplexed genotyping with sequence-tagged molecular inversion probes. Nat Biotechnol (2003) 7.02

Gene expression patterns in human liver cancers. Mol Biol Cell (2002) 6.93

A genomic storm in critically injured humans. J Exp Med (2011) 6.67

Genetics. Genomic research and human subject privacy. Science (2004) 6.56

The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A (2004) 6.34

Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32

Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res (2005) 6.32

A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae). Proc Natl Acad Sci U S A (2003) 6.19

Distinct modes of regulation by chromatin encoded through nucleosome positioning signals. PLoS Comput Biol (2008) 5.71

A global analysis of Caenorhabditis elegans operons. Nature (2002) 5.29

A 3D digital atlas of C. elegans and its application to single-cell analyses. Nat Methods (2009) 5.29

Dissecting the architecture of a quantitative trait locus in yeast. Nature (2002) 5.24

Microbes on the human vaginal epithelium. Proc Natl Acad Sci U S A (2005) 5.15

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A (2004) 5.10

Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics (2005) 5.08

Evidence for an instructive mechanism of de novo methylation in cancer cells. Nat Genet (2006) 4.97

Systematic screen for human disease genes in yeast. Nat Genet (2002) 4.97

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science (2005) 4.74

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell (2008) 4.72

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A (2003) 4.67

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59

A module of negative feedback regulators defines growth factor signaling. Nat Genet (2007) 4.35

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16

Multigene amplification and massively parallel sequencing for cancer mutation discovery. Proc Natl Acad Sci U S A (2007) 3.93

Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns. Genes Cancer (2010) 3.78

Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One (2012) 3.74

X-chromosome silencing in the germline of C. elegans. Development (2002) 3.69

The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans. Nat Genet (2005) 3.58

A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Proc Natl Acad Sci U S A (2007) 3.52

Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49

A comprehensive assay for targeted multiplex amplification of human DNA sequences. Proc Natl Acad Sci U S A (2008) 3.48

Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol (2005) 3.48

Global analysis of dauer gene expression in Caenorhabditis elegans. Development (2003) 3.38

Multiplex protein assays based on real-time magnetic nanotag sensing. Proc Natl Acad Sci U S A (2008) 3.34

Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34

Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans. Curr Biol (2002) 3.30

High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing. Proc Natl Acad Sci U S A (2007) 3.25

Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22

Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys (2008) 3.22

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A (2009) 3.19

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science (2003) 3.19

Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev (2007) 3.16

Straightening Caenorhabditis elegans images. Bioinformatics (2007) 3.13

Genomic profiling reveals alternative genetic pathways of prostate tumorigenesis. Cancer Res (2007) 3.13

Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet (2005) 3.09

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat Cell Biol (2008) 3.08

Transcriptional profile of aging in C. elegans. Curr Biol (2002) 3.02

Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A (2004) 2.99

Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy. Kidney Int (2012) 2.97

Transcriptional programs activated by exposure of human prostate cancer cells to androgen. Genome Biol (2002) 2.87

Genome-wide measurement of RNA folding energies. Mol Cell (2012) 2.85

TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet (2007) 2.84

Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res (2006) 2.81

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci U S A (2010) 2.74

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci U S A (2002) 2.72

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest (2008) 2.71

Urinary TMPRSS2:ERG and PCA3 in an active surveillance cohort: results from a baseline analysis in the Canary Prostate Active Surveillance Study. Clin Cancer Res (2013) 2.70