Published in J Neurosci on August 01, 2007
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
Chloride regulation in the pain pathway. Brain Res Rev (2008) 1.55
Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol (2008) 1.37
Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev (2008) 1.35
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol (2011) 1.15
TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol (2011) 1.15
I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One (2008) 1.09
T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A (2011) 1.06
The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors. J Physiol (2011) 0.99
Modulation of neuronal signal transduction and memory formation by synaptic zinc. Front Behav Neurosci (2011) 0.98
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci (2009) 0.95
Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience (2013) 0.93
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. Br J Pharmacol (2012) 0.92
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One (2012) 0.92
Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal (2013) 0.91
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol (2010) 0.91
Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels. J Biol Chem (2009) 0.89
Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch (2013) 0.89
Redox and nitric oxide-mediated regulation of sensory neuron ion channel function. Antioxid Redox Signal (2014) 0.88
Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception. J Physiol (2016) 0.88
Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes (2013) 0.87
Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation. J Med Life (2011) 0.86
Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch (2014) 0.83
Modulation of T-type calcium channels by bioactive lipids. Pflugers Arch (2014) 0.81
CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One (2014) 0.81
Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol (2012) 0.81
Voltage-gated calcium channel antagonists and traumatic brain injury. Pharmaceuticals (Basel) (2013) 0.80
Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo. J Physiol (2012) 0.79
A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors. Biophys J (2010) 0.79
Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating. Pflugers Arch (2010) 0.79
Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels. Mol Neurobiol (2013) 0.77
Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639. ACS Med Chem Lett (2015) 0.77
Redox and trace metal regulation of ion channels in the pain pathway. Biochem J (2015) 0.76
Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability. J Physiol (2016) 0.76
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep (2015) 0.75
AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesia. Br J Pharmacol (2013) 0.75
Redox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P. Antioxid Redox Signal (2016) 0.75
Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. Br J Pharmacol (2017) 0.75
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev (2005) 5.25
Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res (2002) 2.70
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci (2010) 2.57
Channel-mediated tonic GABA release from glia. Science (2010) 2.42
Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. Neuron (2005) 2.23
Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood (2003) 2.05
Thalamic control of visceral nociception mediated by T-type Ca2+ channels. Science (2003) 2.03
Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci (2002) 1.79
Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci (2007) 1.69
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window. J Neurosci (2010) 1.64
Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ Res (2006) 1.62
TASK channel deletion in mice causes primary hyperaldosteronism. Proc Natl Acad Sci U S A (2008) 1.61
Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res (2006) 1.59
Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact. Trends Pharmacol Sci (2008) 1.56
Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. Circulation (2005) 1.52
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci (2005) 1.52
Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. J Physiol (2002) 1.48
Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels. Proc Natl Acad Sci U S A (2004) 1.44
International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels. Pharmacol Rev (2003) 1.43
Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol (2008) 1.37
High resolution electroencephalography in freely moving mice. J Neurophysiol (2010) 1.37
General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology (2011) 1.36
Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron (2003) 1.35
Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev (2008) 1.35
The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res (2009) 1.34
Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci (2005) 1.33
A mechanism for the direct regulation of T-type calcium channels by Ca2+/calmodulin-dependent kinase II. J Neurosci (2003) 1.31
Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice. J Assoc Res Otolaryngol (2004) 1.29
Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc Natl Acad Sci U S A (2003) 1.29
Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice. J Physiol (2005) 1.28
Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. J Neurosci (2005) 1.28
Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci (2002) 1.26
Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J Neurosci (2004) 1.26
Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane. J Physiol (2005) 1.25
Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest (2012) 1.24
A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels. J Biol Chem (2005) 1.22
Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice. Proc Natl Acad Sci U S A (2007) 1.22
The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. J Neurosci (2007) 1.19
P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells. J Neurosci (2004) 1.18
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol (2006) 1.18
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res (2004) 1.17
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol (2011) 1.15
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci (2007) 1.14
Simultaneous recording of brain activity and functional connectivity in the mouse brain. Conf Proc IEEE Eng Med Biol Soc (2009) 1.14
Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels. FEBS Lett (2005) 1.13
T-type calcium channel regulation by specific G-protein betagamma subunits. Nature (2003) 1.13
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol (2005) 1.12
I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One (2008) 1.09
Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. Biophys J (2002) 1.09
Role of voltage-gated calcium channels in epilepsy. Pflugers Arch (2009) 1.08
Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci (2012) 1.08
Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. Am J Physiol Lung Cell Mol Physiol (2009) 1.07
Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism. Channels (Austin) (2011) 1.07
Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive. Proc Natl Acad Sci U S A (2010) 1.07
Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J Neurosci (2010) 1.06
Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators. J Clin Invest (2012) 1.05
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II. J Clin Invest (2006) 1.05
The role of peripheral T-type calcium channels in pain transmission. Cell Calcium (2006) 1.03
T-type Ca2+ channels in normal and abnormal brain functions. Physiol Rev (2013) 1.03
Cav2.3 channels are critical for oscillatory burst discharges in the reticular thalamus and absence epilepsy. Neuron (2011) 1.03
Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PLoS One (2008) 1.02
Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density. J Physiol (2006) 1.02
Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamus. J Neurosci (2008) 1.02
Thyrotropin-releasing hormone increases GABA release in rat hippocampus. J Physiol (2006) 1.02
Stimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C). J Physiol (2002) 1.01
Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol (2002) 1.01
TASK-3 channel deletion in mice recapitulates low-renin essential hypertension. Hypertension (2012) 1.01
Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels. J Biol Chem (2002) 1.00
Adrenergic facilitation of GABAergic transmission in rat entorhinal cortex. J Neurophysiol (2007) 1.00
Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci U S A (2011) 1.00
In vivo differentiation of mouse embryonic stem cells into hepatocytes. Cell Transplant (2002) 1.00
Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther (2008) 1.00
Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes. Mol Cells (2006) 0.99
Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus. J Physiol (2007) 0.99
Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels. J Biol Chem (2008) 0.99
Expression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticity. J Mol Cell Cardiol (2010) 0.98
T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex. J Neurosci (2012) 0.97
Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci (2010) 0.97
Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice. J Neurosci Res (2003) 0.97
Molecular basis of R-type calcium channels in central amygdala neurons of the mouse. Proc Natl Acad Sci U S A (2002) 0.97
Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. J Neurosci (2009) 0.96