Published in Blood on February 13, 2003
Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiol (2006) 3.34
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem (2011) 2.25
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol (2005) 2.11
Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal (2008) 1.81
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci (2008) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood (2015) 1.47
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins (2010) 1.39
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. J Cell Biol (2006) 1.21
AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J Biol Chem (2010) 1.19
Mechanisms tagging senescent red blood cells for clearance in healthy humans. Front Physiol (2013) 1.18
Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med (2007) 1.16
Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.15
Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. Antioxid Redox Signal (2010) 1.15
Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production. Biochem J (2007) 1.13
Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J Cell Biol (2007) 1.12
Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci U S A (2011) 1.11
Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J (2009) 1.10
Protein glutathionylation in the regulation of peroxiredoxins: a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators. Antioxid Redox Signal (2012) 1.09
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat Rev Cancer (2008) 1.08
Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae. PLoS Genet (2009) 1.06
Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress. Free Radic Biol Med (2010) 1.06
Thiol-based redox switches. Biochim Biophys Acta (2014) 1.03
Tuning of peroxiredoxin catalysis for various physiological roles. Biochemistry (2014) 1.02
Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II. J Biol Chem (2009) 1.00
Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci U S A (2014) 0.98
Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic Res Cardiol (2008) 0.98
Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochem J (2009) 0.98
The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism. Free Radic Biol Med (2009) 0.96
Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal (2012) 0.96
Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis. Oncotarget (2011) 0.96
Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. Am J Physiol Heart Circ Physiol (2008) 0.95
Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins. Proc Natl Acad Sci U S A (2003) 0.95
Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). Free Radic Biol Med (2008) 0.94
Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Dev Cell (2011) 0.93
Measurement of peroxiredoxin activity. Curr Protoc Toxicol (2011) 0.93
Impact of natural genetic variation on gene expression dynamics. PLoS Genet (2013) 0.93
Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis. Kidney Int (2011) 0.92
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis. Antioxid Redox Signal (2015) 0.90
Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair. J Biol Chem (2010) 0.90
Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice. Haematologica (2015) 0.89
Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. Antioxid Redox Signal (2010) 0.88
UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem (2008) 0.87
Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses. Haematologica (2013) 0.87
Role of the membrane in the formation of heme degradation products in red blood cells. Life Sci (2009) 0.86
The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions. Front Physiol (2015) 0.86
Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. Free Radic Biol Med (2012) 0.84
Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model. PLoS One (2014) 0.83
LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. J Clin Invest (2015) 0.82
Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus. World J Nephrol (2015) 0.82
Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae. Cancer Res (2008) 0.82
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev (2016) 0.81
Serotonin is a key factor for mouse red blood cell survival. PLoS One (2013) 0.81
Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors. BMC Cancer (2010) 0.80
Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging. J Clin Exp Pathol (2012) 0.80
Natural history of the bruise: formation, elimination, and biological effects of oxidized hemoglobin. Oxid Med Cell Longev (2013) 0.80
Selectively decreased expression of peroxiredoxins induced by silica in pulmonary epithelial cells. Korean J Intern Med (2009) 0.80
Peroxiredoxin V: A candidate breast tumor marker of population specificity. Mol Clin Oncol (2013) 0.80
Peroxiredoxin II negatively regulates lipopolysaccharide-induced osteoclast formation and bone loss via JNK and STAT3. Antioxid Redox Signal (2015) 0.80
Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. Am J Cancer Res (2014) 0.79
Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage. J Histochem Cytochem (2013) 0.79
Peroxiredoxin-2 recycling is inhibited during erythrocyte storage. Antioxid Redox Signal (2014) 0.78
The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells. PLoS One (2016) 0.78
Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function. J Biol Chem (2015) 0.77
Cell stress proteins in atherothrombosis. Oxid Med Cell Longev (2012) 0.77
Peroxiredoxins and the Regulation of Cell Death. Mol Cells (2016) 0.77
Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma (2012) 0.77
Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. PLoS One (2014) 0.77
The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development. Cancer Lett (2015) 0.77
Antioxidant enzymes as redox-based biomarkers: a brief review. BMB Rep (2015) 0.76
A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell (2015) 0.76
Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. J Virol (2012) 0.76
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. Oncogene (2015) 0.76
2-Cys peroxiredoxin is required in successful blood-feeding, reproduction, and antioxidant response in the hard tick Haemaphysalis longicornis. Parasit Vectors (2016) 0.75
Retracted Cysteine-independent Catalase-like Activity of Vertebrate Peroxiredoxin 1 (Prx1). J Biol Chem (2015) 0.75
Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes. Wien Med Wochenschr (2011) 0.75
The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome. Proteome Sci (2014) 0.75
Loss of the clock protein PER2 shortens the erythrocyte life span in mice. J Biol Chem (2017) 0.75
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium. Sci Rep (2017) 0.75
Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels. Development (2017) 0.75
Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem (2002) 5.08
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr Opin Cell Biol (2005) 3.83
Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell (2010) 3.82
Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function. Cell (2004) 3.65
Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation. Science (2003) 3.60
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A (2004) 3.49
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res (2002) 2.70
Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. J Biol Chem (2002) 2.68
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci (2010) 2.57
Channel-mediated tonic GABA release from glia. Science (2010) 2.42
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J Biol Chem (2004) 2.32
Analysis of the H19ICR insulator. Mol Cell Biol (2007) 2.29
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature (2005) 2.29
Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. Neuron (2005) 2.23
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med (2002) 2.15
Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem (2004) 2.14
Thalamic control of visceral nociception mediated by T-type Ca2+ channels. Science (2003) 2.03
2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends Mol Med (2005) 2.02
Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal (2005) 2.00
Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence. J Biol Chem (2003) 1.90
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem (2004) 1.86
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Cellular regulation by hydrogen peroxide. J Am Soc Nephrol (2003) 1.85
Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol (2004) 1.82
Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci (2002) 1.79
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. Blood (2011) 1.73
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab (2012) 1.65
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window. J Neurosci (2010) 1.64
Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ Res (2006) 1.62
Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem (2002) 1.61
Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res (2006) 1.59
Peroxiredoxins in breast carcinoma. Clin Cancer Res (2003) 1.59
Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol (2009) 1.58
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation. J Biol Chem (2002) 1.54
Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1. Proc Natl Acad Sci U S A (2005) 1.53
Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. Circulation (2005) 1.52
Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin. J Biol Chem (2006) 1.52
Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Cancer Res (2005) 1.46
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology (2007) 1.45
Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels. Proc Natl Acad Sci U S A (2004) 1.44
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest (2010) 1.41
Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol (2010) 1.40
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins. Antioxid Redox Signal (2009) 1.39
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci (2007) 1.38
High resolution electroencephalography in freely moving mice. J Neurophysiol (2010) 1.37
Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron (2003) 1.35
Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem (2003) 1.35
The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res (2009) 1.34
Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. Mol Cell (2012) 1.34
Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos. Biochem Biophys Res Commun (2004) 1.33
VDUP1 is required for the development of natural killer cells. Immunity (2005) 1.31
Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice. J Assoc Res Otolaryngol (2004) 1.29
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. J Biol Chem (2003) 1.29
Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc Natl Acad Sci U S A (2003) 1.29
Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice. J Physiol (2005) 1.28
Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. J Neurosci (2005) 1.28
Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells. Life Sci (2011) 1.27
Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity. J Biol Chem (2008) 1.27
Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J Neurosci (2004) 1.26
Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci (2002) 1.26
Genetic approach to elucidation of sasang constitutional medicine. Evid Based Complement Alternat Med (2009) 1.26
Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alpha. FASEB J (2003) 1.25
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J Biol Chem (2009) 1.25
Characterization of neural cell types expressing peroxiredoxins in mouse brain. Neurosci Lett (2005) 1.25
Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest (2012) 1.24
Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice. Proc Natl Acad Sci U S A (2007) 1.22
Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells. Biochem Biophys Res Commun (2007) 1.19
Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer (2004) 1.19
Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA. J Immunol Methods (2008) 1.18
P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells. J Neurosci (2004) 1.18
Serial cloning of pigs by somatic cell nuclear transfer: restoration of phenotypic normality during serial cloning. Dev Dyn (2007) 1.17
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res (2004) 1.17
Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med (2007) 1.16
Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. Antioxid Redox Signal (2010) 1.15
Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evid Based Complement Alternat Med (2011) 1.14
Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha. J Biol Chem (2003) 1.14
Simultaneous recording of brain activity and functional connectivity in the mouse brain. Conf Proc IEEE Eng Med Biol Soc (2009) 1.14
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III. J Biol Chem (2009) 1.11
Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression. Free Radic Biol Med (2012) 1.11
Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation. J Biol Chem (2004) 1.11
Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression. Antioxid Redox Signal (2011) 1.11
Activity assay of mammalian 2-cys peroxiredoxins using yeast thioredoxin reductase system. Anal Biochem (2005) 1.09